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Alchemica

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  1. Alchemica

    Free Heimia salicifolia

    OK I'll reserve the above people for cuttings and get in touch soon. Thanks for the interest
  2. Alchemica

    Free Heimia salicifolia

    Have some rooted cuttings (3 x tubestocks) for people interested (No WA/TAS) Free including post. Just starting to root so I'll give them a bit longer before posting but express any interest here.
  3. Alchemica

    Indole-3-butyric acid to get Tricho to pup?

    I tend to hear of 6-benzylaminopurine being used for pupping which is quite a distinct compound (synthetic cytokinin with stimulatory effects on cell division) with a different mechanism to IBA That said, try it and see what happens. IBA has: - auxin-like effects such as root initiation, stem bending, and leaf epinasty - IBA-derived auxin has strong roles in various aspects of root development, including regulation of root apical meristem size, root hair elongation, lateral root development, and formation of adventitious roots. - IBA-derived auxin plays distinct roles in shoot development, with particular roles in cotyledon expansion and apical hook formation. Some studies indicate: - IBA application promotes elongation of stems in intact pea plants "IBA could act as an important source of auxin to boost stem elongation in intact plants" - In carrots it seems to cause longer plants "IBA significantly increased the overall plant length."
  4. Alchemica

    Trichodiadema sp?

    Anyone have personal experience with these plants? Curious as I can only find limited info on their use. Trichodiadema stellatum (syn. barbatum) This plant has been used as a yeast substitute for brewing beer and is reported to contain the psychoactive alkaloid mesembrine (Watt & Breyer-Brandwijk, 1962). Laidler (1928) also states that this plant known as kareemoer is “one of the beer making roots, a deliriant and intoxicant with an earlier stimulant action”. HARGREAVES 1998 notes that it is believed to contain an intoxicating alkaloid (“probably mesembrine”) Positive general alkaloid tests (ZWICKY) were had for Trichodiadema barbatum Mesembs reported to contain mesembrine alkaloids Trichodiadema barbatum (unconfirmed) Trichodiadema bulbosum (unconfirmed) Trichodiadema intonsum (unconfirmed) - FESTI & SAMORINI 1995 They have a nice fat root system that could be useful (similarly to D. bosseranum)
  5. Can offer free cuttings of Lampranthus spectabilis (Red) if interested. I can't properly explore as my serotonin transporter is heavily occupied but as it's a rampant grower and a different colour for the garden, it might be a useful addition. Have dried research material if needed too. Let me know in this thread if interested and I'll get back to you once the festive craziness has quietened down While it is claimed "...it would be almost impossible to achieve any pharmacological response from genera other than Sceletium" [1], recently Lampranthus species have been specifically marketed as "Chinese Kanna", alongside being used as an adulterant, one source stating Lampranthus spectabilis generally contains about 1–1.5% total alkaloids [2]. A high concentration of phenolics has been noted in Lampranthus [3], along with other phytoconstituents [4] "Of the five Lampranthus species tested, only L. aureus and L. spectabilis yielded mesembrenol, while all the other Lampranthus species investigated appeared to contain mesembrenone, but all at very low levels." Lampranthus aureus appears to contain other indolic alkaloids Mesembrine: SERT inhibition [other claims of 5-HT releasing activity], PDE-4 inhibition, Anti-inflammatory, Cytoprotective, Upregulates VMAT-2, Mild inhibition of AChE, Mild MAO inhibition, limited reuptake of NE and DA at high concentrations Mesembrenone/mesembrenol: SERT inhibition, PDE-4 inhibition [1] https://doi.org/10.1076/phbi.36.3.173.6350. [2] https://botany.bio/product/chinese-kanna-1-25-powder/ [3] https://doi.org/10.15835/nbha47411617 [4] https://doi.org/10.1016/j.sajb.2018.07.014
  6. Alchemica

    Aptenia cordifolia (A Zulu traditional medicine)

    Just updating this - there seems to be confusion between A. cordifolia (Mesembryanthemum cordifolium) and A. lancifolia and there are common hybrids between the two. Aptenia cordifolia and A. lancifolia are very popular garden plants around the world, and are particularly useful as attractive ground covers on dry slopes as they rapidly form lush green carpets with decorative reddish purple flowers. A. cordifolia has cordate or heart-shaped leaves, while the leaves of A. lancifolia are lance-shaped, tapering gradually towards their bases. Leaf shape is used as a rather tenuous character in distinguishing A. cordifolia from its nearest relative, A. lancifolia.
  7. Alchemica

    Aptenia cordifolia (A Zulu traditional medicine)

    Mesembryanthemum cordifolium L.f. (syn. Aptenia cordifolia) Think there's some variety in colour
  8. Alchemica

    Aptenia cordifolia (A Zulu traditional medicine)

    I've just mashed it and put it in a jar, sun fermented then oven dried (smells a bit...) before to get a usable powder as per herbalistics DIY Sceletium fermentation page. Bigger batches including roots were problematic with mold. I needed high doses to get effects but I'm a bit of a serotonergic hard head. I personally don't think you'd get enough of a dose via insufflation.
  9. Alchemica

    treating hypertension with herbs

    One I've heard of and seems to be very otherwise benign is Hibiscus/Rosella Rosella appears to be a safe and well-tolerated treatment option, which may have a place in the treatment of mild-to-moderate essential hypertension. Data suggests that it may provide comparable effectiveness to some pharmaceutical antihypertensive medications. [1]
  10. Alchemica

    Tabernaemontana

    Looking for various Tabernaemontana - divaricata, pandacaqui etc. Any that may be phytochemically interesting Message me if you have surplus Many thanks in advance
  11. Alchemica

    Kanna - Sceletium Tortuosum Seed Confiscated & Destroyed

    There may possibly be if someone has cancers etc, BDNF participates in the process of metastasis and in the migration of cancer cells . That said, exercise induces similar sorts of elevations of BDNF and it's generally considered wholesomely healthy
  12. Alchemica

    Kanna - Sceletium Tortuosum Seed Confiscated & Destroyed

    There'd likely be BDNF elevations [seen in animal studies here] and enhanced neurogenesis on chronic dosing (in line with the therapeutic activity seen in depression where case-studies note delayed improvements, eg 1-2 weeks, 10 days etc) from both the serotonergic effects and PDE4 inhibition
  13. Alchemica

    Kanna - Sceletium Tortuosum Seed Confiscated & Destroyed

    Trying to root up cuttings at the moment, if I have success I'll be in touch It's really annoying as it's a potent therapeutic and it would be good to have it remain therapeutically appreciated, rather than abused. It's made the list of the United Nations “plants of concern.” and features in some drug testing/analysis papers so probably be an issue soon [1].
  14. Alchemica

    Kanna - Sceletium Tortuosum Seed Confiscated & Destroyed

    "Based on the venation type, the species is mainly classified as either emarcidum or tortuosum types. In the emarcidum type, the leaf is more flat and the dried leaf venation pattern shows a central main vein with the curved secondary vein which branches off the main vein, reaching the leaf margins. In plants of the tortuosum type, the dry leaves are more concave and usually show about three to five or sometimes up to seven major parallel veins. The secondary veins run straight up to the apex on both sides of the middle vein." https://www.intechopen.com/chapters/53426 While the emarcidum is much easier to grow it seems to be devoid of mesembrine and instead comprised of 4'-O-demethylated mesembrine-type alkaloids [1, 2] which are poorly characterised pharmacologically. S. strictum seems to again have a different alkaloid profile centred on mesembrine and mesembrenone and is proposed to be useful based on that [1] https://doi.org/10.3389%2Ffnut.2022.819753 [2] https://www.intechopen.com/chapters/53426 Pretty sure the first one I have is emarcidum-type and the second tortuosum if that helps you ID.
  15. Alchemica

    Psychoactive Saffron (Crocus sativus)

    I used to think more was better particularly as there seems to be dose-dependent increases in DA levels but then noticed low doses cumulatively ie a pinch seems better... and likely safer as increased doses seem to come with notable toxicity. Not sure where the cut off for CNS toxicity is but considering the clinically used doses are low and they seem effective, maybe wise to keep to lower doses? " saffron constituents such as crocin, crocetin and safranal can exert antioxidant or toxic effects depending on their endogenous concentration. " [1]
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