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Alchemica

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About Alchemica

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  1. Alchemica

    Eremophila

    Thought I'd share how Eremophila are currently being studied Biodiscoveries within the Australian plant genus Eremophila based on international and interdisciplinary collaboration: the results and perspectives on outstanding ethical dilemmas Personally, the most interesting finding was DAT modulating compounds from E. oppositifolia The latest (unpublished) results comprise the identification of compounds isolated from Eremophila species, capable of both potentiating and inhibiting the transport of dopamine The search for novel ligands from Eremophila species targeting neurotransmitter:sodium symporters Abstract: The family of neurotransmitter:sodium symporters (NSSs) mediate rapid re-uptake of neurotransmitters released to the synaptic cleft making them important determinants of neuronal communication. Accordingly, drugs that modulate their activity are central for the treatment of many neuropsychiatric diseases, such as depression, attention deficit hyperactivity disorder (ADHD), anxiety and narcolepsy. However, many patients do not respond adequately to the current drugs. Others stop the treatment due to severe side effects. In addition, high-affinity inhibitors for many NSS proteins are still to be found. Here, we present results from purified compounds and extracts from Eremorphila species for their activity towards the dopamine transporter (DAT). We find that the addition of the branched chain fatty acid KU030-14 potentiated DAT transport of dopamine. We also found several extracts that inhibited DAT activity. Taken together, we find it possible that Eremorphila species contain one or more active compounds towards DAT and possibly also other NSS proteins. https://synbio.ku.dk/calendar/2019/1st-cross-continent-eremophila-conference/speaker-information/
  2. Alchemica

    Interactive Metabolic Pathways Map

    New Discoveries in Magic Mushroom Enzymes - Psychedelic Science Review (psychedelicreview.com) Fungi seem to have different enzymes that hydroxylate the indoleamines at the 4 position (tryptamine-4-monooxygenase), whereas other metabolic pathways lead to 5-OH (eg enzymes like tryptophan-5-hydroxylase) If you consider the numbering on the indole nucleus that might help you get an idea of the way it's numbered Consider changing the hydroxyl position from 4-OH to 5-OH changes a major part of the molecular structure that allows different binding characteristics to different receptors Take for example serotonin (5-OH-tryptamine) binds something like this to 5-HT2ARs Psilocybin binds more like this Consider how it changes the location of the hydroxyl group to allow different strength intermolecular forces with receptor proteins causing different binding profiles An important determinant of the neurobehavioral responses induced by a drug is its relative receptor selectivity. These different molecular structures allow different receptor binding profiles eg Psilocin: 4.00 5ht2b, 3.40 5ht1d, 3.37 D1, 3.03 5ht1e, 2.88 5ht1a, 2.83 5ht5a, 2.82 5ht7, 2.82 5ht6, 2.67 D3, 2.52 5ht2c, 2.19 5ht1b, 2.14 5ht2a, 1.77 Imidazoline1, 1.74 SERT, 1.57 Alpha2B, 1.36 Alpha2A, 1.03 Alpha2C where higher numbers mean higher binding. A 5-OH vs a 4-OH will change the profile of receptor binding
  3. Can chuck some blue corn and Glass Gem Rayaa in an envelope no cost just PM me. Also Oaxacan Green Can't guarantee viability but chuck it in the ground and see I'll have more purple corn soon hopefully as a late crop is almost nearly done. Also have maybe 10 Glass Gem Rayaa corns I picked slightly too early, you're welcome to them if you can use them experimentally for your bourbon
  4. Alchemica

    Brahmi, gotu kola

    I can give you Centella asiatica [1] (what I was sold as C. asiatica) and what I think is Centella cordifolia (Swamp pennywort) [2] Let me know if they're suitable 1. 2.
  5. I'd suggest Sacred and herbal healing beers: the secrets of ancient fermentation as a starting point. I've PM'd the link If you wanted to get technical, I tried to brew with things early in the mix if I wanted to encourage potential bioconversion of actives, or add them later if the actives were likely to be degraded to less active metabolites. You could consider if the actives are likely to be destroyed, or bioconverted to more potent ones with a bit of research "...fermentation could be considered as a potential technology for releasing phenolic compounds from natural resources, as well as for producing new bioactive compounds. The ability of fermentation to improve the yield and to change the profile of phenolic compounds is mainly due to the release of bound phenolic compounds, as a consequence of the degradation of the cell wall structure by enzymes produced during fermentation." [1] The simple recipes simply use things like: Lemon BaIm AIe 4 pounds dark brown sugar 3 gallons water 1/2 pound dried lemon balm herb yeast Boil 3 gallons water with 8 ounces dried lemon balm herb and 4 pounds sugar for one hour; skim off scum. Let cool and strain into fermenter. Add yeast. Ferment until complete; 7 to 10 days. Prime bottles, fill with beer, and cap. Ready to drink in one to two weeks.
  6. Back to playing with essential oils... There's some new papers Exploring Pharmacological Mechanisms of Essential Oils on the Central Nervous System A Review of the Potential Use of Pinene and Linalool as Terpene-Based Medicines for Brain Health The main oil I've been diffusing is Eucalyptus because it's not only cheap but it seems to have some neat benefits on paper. Also fond of lavender still. 1,8-cineole can elevate synaptic 5-HT levels by increasing the releasable synaptic pools of 5-HT, exocytosis and levels in the synapse and is a novel therapy for treating depression [1] It has anti-inflammatory and antioxidant effects. It is proposed to be a NMDA antagonist and AChE inhibitor [2] with plasma 1,8-cineole concentrations correlated with cognitive performance [3] Increases in dopamine release with exposure to 1,8-cineole and eucalyptus oil were 241 ± 29% and 182 ± 16%, respectively [4]
  7. Alchemica

    Kombucha

    There's initial human studies on some of the probiotic strains used in commercial kombucha's eg Bacillus coagulans GBI-30, 6086 Clinical studies showed that consuming BC30 helped alter the gut microbiome by increasing the numbers of beneficial bacteria, and ex vivo testing of blood from elderly humans who had consumed BC30 for 28 days showed increased anti-inflammatory cytokine responses. Results from a recent clinical trial suggest that the consumption of BC30 supports exercise performance and helps reduce exercise-induced muscle damage. Cell walls from the live B. coagulans GBI-30, 6086 strain have demonstrated immune modulating and anti-inflammatory effects in vitro. The immune-modulating effects of the BC30 strain were associated both with the cell wall fraction and with the metabolites produced by the live bacteria in vitro. It has shown benefit in IBS and rheumatoid arthritis
  8. Alchemica

    Ion-exchange resin capsules

    You fiend, sounds like something I would have done. Can't suggest it's good practice to bypass such a safety measure. Normally amine drugs are absorbed onto cationic ion exchange resins with sulfonic acid groups to form : "cation exchange resins contain acidic functional group capable of removing cations from basic solutions. The use of ion exchange resin to prolong the effect of drug release is based on the principle that positively or negatively charged pharmaceuticals, combined with appropriate resins yield insoluble polysaltresinates. Ion exchange resonates when administered orally, they are retained in stomach for two hours in contact with an acidic fluid of pH 1.2 and then move into the intestine at a slightly alkaline pH. Towards the large intestine, desorption from resins and absorption into the body may be slowed due to low fluid content and poor absorption in colon" Here is acidic release in the stomach: Ref I would have thought you could likely do a strong acid eg HCl wash of the resin to liberate the amine.HCl salt into solution but maybe strongly basic conditions to liberate the free amine is the way to go.
  9. Wondering if anyone has ever stumbled across literature on the phytochemistry, toxicology or any use of the Corydalis that seem to be widely available and widespread in Australia? The ones I mainly see are hybrids like C. flexuosa x elata I'm growing it simply as it's attractive with it's blue flowers and as a shade-loving plant but curious if it is otherwise useful? Despite not finding any analysis for flexulosa or elata (other than the anthocyanins in the flower) there is one mention "Those species which grow in China, including C. flexuosa, have been included in the Chinese herbal pharmacological choices for pain relief." [1] One thread here states the types commonly used in Chinese Medicine are: Corydalis yanhusuo, C. turtschaninovii, C. ambigua, C. repens. The most extensive alkaloid breakdown of Corydalis species I can find is unfortunately in a different language and doesn't seem to list any details for flexuosa etc Tetrahydropalmatine for example has been isolated from: C. cava C. decumbens C. intermediata C. ochroleuca C. saxicola C. sempervirens C. solida C. yanhusuo C. ambigua C. caseana C. tashiroi C. lutea C. pallida C. solida C. tashiroi It seems to list some therapeutic Corydalis as: Corydalis ambigua Cham. & Schlatdl Corydalis bulbosa Pers. Corydalis decumbens (Thumb.) Pers. Corydalis chaerophylla DC. Corydalis incisa Pers. Corydalis koidzumiana Ohwi Corydalis longipes DC. Corydalis meifolia Wall. Corydalis pseudoadunca Popov Corydalis ramos Wall. Corydalis saxicola Bunting Corydalis speciosa Maxim. Corydalis turtschaninovii Besser
  10. Has anyone added medicinal Amaryllidaceae to their garden? It's been briefly discussed here over the years here but has anyone found a practical Amaryllidaceae with favourable toxicological properties to grow? I've been interested in them for a bit as garden additions. The first one that got my interest was Boophone disticha whose crude ethanolic extracts and some alkaloidal phytoconstituents possess potent SERT/5-HT1A mediated [One article states triple reuptake inhibition of 5-HT/NE/DA] antidepressant and anxiolytic effects [1] That said, it seems to have some scary toxicity too (unless you like deliriums) and is not broadly available (and $$$) Then there's things like Narcissus pallidulus and Narcissus cv. Hawera. Having to deal with the toxicity of lycorine being present in cv. Hawera sounds unpleasant so Narcissus pallidulus sounds most interesting personally Narcissus cv. Hawera biosynthesizes Sceletium-type and Amaryllidaceae alkaloids [mesembrenone, galanthamine and lycorine as major alkaloids], while The Narcissus species from section Ganymedes (N. triandrus L., N. pallidulus Graells, Narcissus lusitanicus Dorda & Fern. Casas, and N.iohannis Fern. Casas) have been found to biosynthesize mainly mesembrenone (over 70% of all alkaloids). Narcissus pallidulus accumulates only Sceletium-type compounds [mesembrenone and 6-epi-mesembranol]. [2] Mesembrenone represented 64.1 % of the total alkaloid fraction extracted from leaf of Narcissus cv. "Hawera" [3] The highest galanthamine content was identified in Narcissus cv. Sundisc (69% of TIC) and Narcissus cv. Waterperry (67% of TIC)
  11. Alchemica

    Free Purple Corn

    Sorry @bob-bob just missed out, thanks to all who requested seeds. All sent and out of seed.
  12. Alchemica

    Free Lobelia cardinalis seed

    I've got quite a few of these going from seed, small seedlings now, but if anyone missed out (note: state restrictions still apply) and has a SERIOUS actual interest in the plant let me know and I'll try and gift you a small plant once they're a bit bigger, otherwise they get donated to the dark-side of aesthetic flower appreciating grandmas Traditional use: Root infusion for worms, rheumatism; leaf infusion for colds, fever; root poultice for sores Constituents [1]: Aerial parts: alkaloid lobinaline Hairy root culture: diacetylene triol lobetyol + glucosides lobetyolin and lobetyolinin Leaves: anthocyanin cyanidin-3-O-[6-O-(4-O-E-p-coumaroyl-O-α-rhamnopyranosyl)-βglucopyrano]-5-O-β-glucopyranoside See more: https://www.cargocultcafe.com/tag/plant-identification-lobelia-cardinalis/ Some initial bioassays [2]: Positive "when it comes to stimulation, cardinalis is more like nicotine. Seems to give stimulant effects similar to mild nicotine. Seems to have mild aphrodisiac properties. Slight mood lift present it also seems to have anti depressant properties. ...the anti-depressant effects cannot be compared to anything - because you just feel better, it's not anything like pharmaceutical anti-depressants. ...it's painkilling potential is huge. powerful muscle relaxant and really potent painkiller..." Less positive: "L. inflata is far more effective than L. cardinalis and L. siphilitica in my opinion." [1] http://dx.doi.org/10.3390/medicines5040121 [2] https://drugs-forum.com/threads/lobelia-cardinalis.213716/
  13. Alchemica

    Free Purple Corn

    Let them ripen on the plant. split them up then dehydrated at low temp. Worked for my other corns, hopefully these too. Hope you've been enjoying yours!
  14. Alchemica

    Free Purple Corn

    I had a hard time finding a viable seed for purple corn. Tried Morado Pitch Black etc and no luck. I eventually settled on Thai Hybrid F1 Purple Corn. Enjoyed growing those. If anyone wants me to put some free seeds in an envelope just let me know. Not sure what it will revert back to as it's a hybrid but hopefully something purple Once again, sorry, No WA/Tas
  15. Alchemica

    Free Lobelia cardinalis seed

    -just trying my best to be legit without even knowing what I have to technically be legit about... if it's not an issue I still have a few seed pods on their way and can plonk them to where permissible. From what I've heard TAS is pretty strict on even seed
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