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About Alchemica

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  1. Trying different proteins for serotonergic effects (along with Mg/Zn etc) these days Protein source tryptophan from seeds with a high tryptophan-to-total protein ratio can be comparable to pharmaceutical grade tryptophan in some studies [1, 3] They are nutrient-dense and mostly anti-nutrient-free. The seeds of Cucurbita sp.have been traditionally used as medicine. Among the Cucurbitaceae members, pumpkin seeds are big, abundant, and edible. Yet, these seeds are mostly discarded as agro-industrial wastes [1]. They are rich in protein, polyunsaturated fatty acids (PUFA), minerals (magnesium, phosphorous, copper and potassium, iron, zinc, manganese), carotenoids, beta-carotene, and Vitamin E "...a remarkable assortment of health-enhancing nutrients, from magnesium, protein, niacin, and zinc, to its high concentration of tryptophan and essential fatty acids, pumpkin seeds provide a powerful health punch" - anti-inflammatory and anti-oxidative properties - protective activity against cardiovascular diseases - hypoglycaemic properties: Acute consumption of 65 g of pumpkin seed markedly reduced postprandial glycemia. Pumpkin seed has potential as a hypoglycemic food [4] - because of the high tryptophan content, pumpkin seeds might ease depression, anxiety, nervous irritability and insomnia - shown to improve the iron status I like other 'waste' products that are healing, too. [1] https://www.ncbi.nlm.nih.gov/pubmed/18066139 [2] https://www.ncbi.nlm.nih.gov/pubmed/16053244 [3] https://www.ncbi.nlm.nih.gov/pubmed/28463796 [4] https://www.ncbi.nlm.nih.gov/pubmed/30055778 Sure I try to put love into some meals but other times, just need sustenance. I chew through quite a bit of protein powder to keep at 0.8g/kg. Was doing well dropping weight by using that. I've tried so many proteins from hemp to soy but just settle on whey most of the time. Epidemiological and clinical studies have shown that dairy products have beneficial effects on cognitive decline and dementia, which may in part occur through whey peptides [1] As I've sort of subjectively noticed, chronic ingestion of diets differing in protein source elicits marked differences in the brain tryptophan concentrations and serotonin synthesis [2]. and tryptophan concentrations and serotonin synthesis in brain neurons are remarkably sensitive to which protein is present in a meal [3]. Whey protein has been proposed as a potential functional nutritional food supplement that prevents the progression of neurodegenerative disorders [4] and and useful for metabolic disorders [5,6] A hydrolyzed protein source may be more adequate to increase brain tryptophan and 5-HT function compared with intact alpha-lactalbumin protein or pure tryptophan [7]. While there have been "no significant changes in clinical outcomes" in some neurodegenerative disorders like Parkinson's in human studies, it improves some biomarkers [8] Whey consists of a heterogeneous group of proteins, including beta-lactoglobulin (35%), alpha-lactalbumin (12%), proteose peptone (12%), immunoglobulins (8%), and bovine serum albumin (5%) Due to greater solubility, more rapid digestion, and resultant higher plasma concentrations of amino acids, whey appears to be a favourable protein to provide nutritional and functional benefits. alpha-lactalbumin: - Lactalbumin increased plasma tryptophan (3-fold) and the tryptophan ratio (50%) [9] - may enhance sustained alertness early in the morning after an overnight sleep, most likely because of improved sleep [10]. - Dietary protein rich in alpha-lactalbumin improves cognitive performance in stress-vulnerable subjects via increased brain tryptophan and serotonin activities. - Supplements of lactalbumin may be useful for nutrition research in relation to age- or disease-related memory decline [11] [1] https://www.ncbi.nlm.nih.gov/pubmed/30011836 [2] https://www.ncbi.nlm.nih.gov/pubmed/23395255 [3] https://www.ncbi.nlm.nih.gov/pubmed/19454292 [4] https://www.ncbi.nlm.nih.gov/pubmed/29199432 [5] https://www.ncbi.nlm.nih.gov/pubmed/26516411 [6] https://www.ncbi.nlm.nih.gov/pubmed/25888881 [7] https://www.ncbi.nlm.nih.gov/pubmed/18648776 [8] https://www.ncbi.nlm.nih.gov/pubmed/27423583 [9] https://www.ncbi.nlm.nih.gov/pubmed/23395255 [10] https://www.ncbi.nlm.nih.gov/pubmed/15883425 [11] https://www.ncbi.nlm.nih.gov/pubmed/16174675
  2. Yeah that's the one, I assume it could have been a niacin flush but have never had niacin as nicotinic acid, always nicotinamide and never had issues so not sure.
  3. On that, I did use a bit of Nutritional Yeast for a bit thinking it would be good to be all dietary and stuff, bit of protein too. Cheesy and stuff. Good in theory. It's got a fair bit of niacin, don't know if that's why I'd break out in a strange peripheral reaction but really just doesn't compare to supplements many a time IMO. RDIs are not always applicable IMO
  4. Did you not anything @Xperiment Hope you're going OK! Trying to work out what I need without wasting money has been interesting. I've been on and off these. Simply supplementing only B1 leaves you open to not getting enough of the others but I wanted to see if those "Executive B Stress Formulas" etc do anything other than give you fluoro pee? That was what I wanted to see, how I'd go without them. What's your opinion? Do you use them? It is proposed that "supplementation, particularly with those higher in B vitamins, may improve cognition and mood, which might be facilitated by improving brain health" and that dietary intake above the RDI is often useful, particularly for brain health and even when vitamin status, according to the traditional criterion, is adequate there may be significant mental improvements [1]. I stopped my B-group supplementation for quite some time thinking I'd save some slight cash but despite attempts to eat well, I'm not sure it is providing adequacy for B-groups in particular, I started to show some potential deficiency signs physically. I was one of those that tried everything from L-methylfolate to thiamine etc at very high doses but there seems to be personally better effects with the spectrum. I use one with all B-groups at high doses (and methyl-B12), which is realistically affordable as a daily addition A meta‐analysis found that adjunctive treatment with high‐dose B‐vitamins significantly reduced total psychiatric symptoms among 297 long‐term patients in 7 different studies [2] I found thiamine quite a useful addition, but tended to feel it's better to go for the full spectrum at a higher dose. The B-group is proposed to be a useful "complementary therapy in several neuropsychiatric disorders" and "may have specific neuroprotective properties in attention/vigilance" in psychotic disorders [3] and "B vitamins can be useful as complementary strategies" [4] but currently the evidence is "inconsistent". It has been claimed that "administration of the entire B-vitamin group, rather than a small sub-set, at doses greatly in excess of the current governmental recommendations, would be a rational approach for preserving brain health" [5]. "Even in healthy humans, multivitamin supplementation has been shown to improve cognitive performance and reduce negative mood states, including depression, anxiety, and stress" and several studies point "toward the efficacy of vitamin and mineral supplementation, particularly B vitamins, in preventing and alleviating disease and disability" High-dose B-group supplementation [6]: - acutely may improve contentment and cognitive task performance in adults - shown to reduce negative mood states of personal strain, confusion, and depression when administered chronically in healthy individuals - reduced fatigue and improved performance during a cognitive tasks - shown to reduce blood markers for oxidative stress, inflammation and increase brain markers for oxidative metabolism and myelination [1] https://www.ncbi.nlm.nih.gov/pubmed/9122365 [2] https://www.ncbi.nlm.nih.gov/pubmed/28202095 [3] https://www.ncbi.nlm.nih.gov/pubmed/30771856 [4] https://www.ncbi.nlm.nih.gov/pubmed/29171643 [5] https://doi.org/10.3390/nu8020068 [6] https://www.ncbi.nlm.nih.gov/pubmed/30513795
  5. Alchemica


    Hope all are well. I'm still trying to manage this with diet and exercise before it becomes more problematic for me. I'm still dropping kg but have had lots of use of SGAs which cause severe lasting metabolic adverse effects, such as elevated blood glucose and insulin resistance (IR) Still like cinnamon and anthocyanins and a planty diet but have problems still. Trying to find as close to food options as possible. While plain tea can offer some slight dietary support, I'd like more glucoregulatory function Several herbs have also demonstrated benefit in glycemic control in clinical trials. These herbs and herbal extracts include berberine, ginseng, gymnema, banaba, cinnamon, fenugreek, and kudzu. While many of these herbs appear to be promising when used in isolation, the practice of herbal medicine most often utilizes polyherbal combinations for purported synergistic effects [review] While berberine is promising both for it's metabolic effects and on the brain, it's one I do have concerns with regard to interactions with that are clinically relevant "interactions should be considered when berberine is administered" for CYP2D6, 2C9, and CYP3A4. I like fenugreek but it does seem to have some effects on the GI tract that can be less wonderful. Cinnamon seems a useful adjunct as the "polyphenolic polymers, found in cinnamon, appear to potentiate insulin action by increasing phosphorylation of the insulin receptor, thereby increasing insulin sensitivity, which may lead to improvements in blood glucose control and lipid levels". [1] but often with "modest effects" [2] As an isoflavone option that is food based, I like the idea of Kudzu Pueraria lobata could interfere with SGA-associated IR and revert overexpressed IR-related proteins [3]. This is intriguing as it's also a promising rapid-acting antidepressant compound through AMPAR-mTOR signaling pathway activation and increased BDNF [4] exerts anxiolytic-like effects, which may be "associated with normalization of 5-HT levels and biosynthesis of allopregnanolone in brain" [5] and alleviated the behavioural deficits induced by chronic stress [6] and may be a "potentially valuable preventative therapeutics for memory-related nervous disorders" [7]. Have a big bag of standardised kudzu. While chromium supplementation has been promising results are mixed. Saffron is also promising. Review: https://www.ncbi.nlm.nih.gov/pubmed/30616613 [1] https://www.ncbi.nlm.nih.gov/pubmed/30144878 [2] https://www.ncbi.nlm.nih.gov/pubmed/27618575 [3] https://www.ncbi.nlm.nih.gov/pubmed/30946280 [4] https://www.ncbi.nlm.nih.gov/pubmed/30284466 [5] https://www.ncbi.nlm.nih.gov/pubmed/29101599 [6] https://www.ncbi.nlm.nih.gov/pubmed/28740098 [7] https://www.ncbi.nlm.nih.gov/pubmed/28734961
  6. Happy Bicycle Day all. One plant I was really impressed with over the heat was Hibiscus sabdariffa. I didn't know if it would do very well down here but it's pretty much everything I'm looking for in a plant over the warmer time of the year, it thrived in the crazy heat without being a pain to water. Easy to grow, super tough, high yielding as a medicinal and for food. First you get a barrage of beautiful aesthetic flowers then a continuous supply of calyx (albeit mine a little smaller than what I often see commercially) and leaf. The leaf is nice as a cooked/salad green (if you like lemon flavours) and if you want a hit of tasty sourish goodness, the calyx are nice even raw. Plants like this really do make your food your medicine. I have quite a bit of Roselle this year if anyone has interest in free seed soon (No WA/Tas), feel free to express interest. Actually after tips on the best way to collect the seeds, just let them ripen fully on the plant? if anyone has knowledge? I'm a bit conflicted, one source says "usually harvested ten days after the flower blooms. The large flowers fade and fall off, leaving behind their bright red, fleshy lotus shaped calyces. The Roselle flower seeds are then dried to be planted later and the fleshy red calyces are dried or eaten fresh." I've got lots of pods from when I was harvesting calyx - these viable or do the pods need more specific ripening time on the plant? These look viable and currently available: Some permaculture people "definitely recommend planting Rosellas in the garden if you are in a warmer climate." [Good review on this plant] [2] Review on the pharmacology The plant showed antibacterial, anti-oxidant, nephro- and hepato-protective, renal/diuretic effect, effects on lipid metabolism (anti-cholesterol), anti-diabetic and anti-hypertensive effects among others. [3] Using the leaf as a cooked green: Hibiscus sabdariffa is "high in essential nutrients required for optimal performance of health and the maintenance of good health together with the reduction of aging". 10 polyphenols including chlorogenic acids, quercetin, kaempferol etc were identified in the leaves along with good levels of carotenoids showing good antioxidant and anti-inflammatory activity Hibiscus derived polyphenols are known to ameliorate various inflammation-related conditions, including obesity. The mechanism includes the regulation of energy metabolism, oxidative stress and inflammatory pathways, transcription factors, hormones and peptides, digestive enzymes, as well as epigenetic modifications [4] It can be considered as a food rich in lutein, chlorogenic acids and anthocyanins [5]. The organic acids such as hibiscus, dimethyl hibiscus, and hydroxycitric acid were strongly associated with some beneficial health effects [6]. A preliminary study on the use of this as an alternative source of iron for the treatment of anaemia and some other mineral deficiency diseases was promising Different works have demonstrated that Hibiscus sabdariffa extracts reduce blood pressure in humans - this effect is due to angiotensin converting enzyme (ACE) inhibitor activity [7]. The polyphenol content in H. sabdariffa works as an anti-inflammatory by improving antioxidant conditions and regulating the expression of cyclooxygenase-2 [8]. Other Hibiscus anthocyanins have anti-depressant properties through dopaminergic, adrenergic and serotonergic mechanisms [9] . Possibly Effective for: Hibiscus flower normalises blood pressure and exerts a protective effect on the heart. New research is underscoring the possibility of using hibiscus to normalise blood sugar. Reports have shown that H. sabdariffa derived bioactive compounds are potent in the treatment of obesity with an evident reduction in body weight, inhibition of lipid accumulation and suppression of adipogenesis through the PPARγ pathway and other transcriptional factors [10] Low doses of Roselle tea or supplements appear to be effective in reducing blood pressure, and may be anti-diabetic. High blood pressure. Some early research shows that drinking hibiscus tea for 2-6 weeks decreases blood pressure in people with mildly high blood pressure. Other early research shows that taking a hibiscus extract by mouth for 4 weeks may be as effective as the prescription drug captopril for reducing blood pressure in people with mild to moderate high blood pressure. However, an analysis of results from various clinical studies suggests that there is not enough evidence to draw strong conclusions about the effects of hibiscus in reducing high blood pressure [11]. Also heaps of Ashwagandha seed still left.
  7. If it is present to an appreciable degree, it is theoretically degraded so quickly by FAAH after oral administration that it's likely not that relevant but some propose there are N-acylethanolamines that slow degradation also in the chocolate. That said some of the fatty acid amides I've found orally sometimes do something at high enough doses. It may be that the abundant catechin flavonols, which seem to have moderate affinity to cannabinoid receptors (and other receptors) are more active. You've got a good lot of fatty acids, some with affinity to CNS receptors, that could also alter endocannabinoid tone. The pharmacology of the tetrahydro-beta-carbolines and isoquinolines in chocolate isn't well established from my understanding One fairly recent review links most of the psychoactivity to these main constituents: "...we would like to propose the “mood pyramid” as a model, summarizing the more general up to the more specific psychopharmacological actions of cocoa and chocolate. There is a large amount of scientific evidence that the flavonoids, more in particular CF, are involved in the cognition-enhancing effects, although this may not be very specific for cocoa or chocolate, since these constituents are widely distributed in nature and in food. At the second level, the methylxanthines caffeine and theobromine have additive and maybe synergistic effects on cognition and alertness, although the role of theobromine remains unclear. Methylxanthines are less common in nature than flavanols, but still not restricted to T. cacao. At the third and gradually more specific level, the tetrahydro-isoquinoline alkaloids, more in particular salsolinol, may exert additive or synergistic activities" [1].
  8. Really good review, some people here will likely be interested. One I'm surprised didn't get mentioned is β-caryophyllene for it's notable CB2 affinity. I've never been interested in potent CB1 agonists but these other plants interest me. New to me is seeing anthocyanins as cannabinoid modulators Cannabimimetic plants: are they new cannabinoidergic modulators? https://dx.doi.org/10.1007/s00425-019-03138-x [sci-hub] In nature, surprisingly many molecules act on the endocannabinoid system through cannabinoid receptors, degradation or synthesis enzymes. Phytochemicals and secondary metabolites able to interact with the endocannabinoid system have been recently described in a broad range of plants and fruits. It's interesting how changes to diet have likely altered our endocannabinoid system: "...the transition from high-protein hunting and gathering society, to one based on agriculture, and hyper-glucidic and -lipidic, has favored the over-activation of CB1R" Some plants Cannabigerol-like phytocannabinoids called amorfrutins have been identified in the genus Helichrysum Several amorfrutins have been isolated from liverwort belonging to the genus Radula and from two species of the Fabaceae family, Amorpha fruticosa and Glycyrrhiza acanthocarpa Molecules structurally similar to CBD are ferruginene compounds and methylpenanol analogs of CBD extracted from Rhododendron ferrugineum, species belonging to the Ericaceae family. Rhododendron dauricum, a flowering plant belonging to the family Ericaceae native to the North Asian forests, produces daurichromenic acid (DCA) Guineensine belongs to a class of N-alkylamide alkaloids, first isolated from West African pepper (Piper guineense). They are also abundant in numerous other species of Piper genus, such as in P. longum and P. nigrum (the dietary pepper species) guineensine has ability to inhibit the central reuptake of the major endocannabinoids Chelerythrine, present in the plants Chelidonium majus, Zanthoxylum clavaherculis, and Zanthoxylum rhoifolium, and sanguinarine, extracted from Sanguinaria canadensis, Argemone mexicana, Chelidonium majus, and Macleaya cordata, are two benzophen-anthridine alkaloid with potential cannabimimetic action Out of six kavalactones, yangonin has shown good selectivity for CB1R compared to CB2R γ-Sanshool is another alkaloid, extracted from plant genus Zanthoxylums uch as Z. clava-herculis, Z. armatum, Z. bungeanum, Z. piperitum. γ-Sanshool displayed an antagonist profile for CB1R and simultaneously an agonist activity for CB2R From Voacanga africana, three alkaloids with CB1R antagonism, voacamine, 3,6-oxidovoacangine, and 5-hydroxy-3,6-oxidovoacangine, have been isolated. The crude extract of Voacanga africana has been used for the treatment of diseases connected to endocannabinoid systems such as chronic inflammation, mental disorders, and convulsions in children. Indeed, based on binding studies, it was established that these three alkaloids could be considered modulators of CB1R. α-Amyrin and β-amyrin are pentacyclic triterpenes, ubiquitously distributed in the plant kingdom, known to have a number of biological effects produced via indi-rect cannabimimetic mechanisms. α-amyrin is isolated from the resins of Bursera and Protium species of the Burseraceae family. The key sources for β-amyrin include Amphipterygium adstringens, Eucalyptus globulus, Ficus carica, Ficus cordata, Nelumbo nucifera and Byrsonima crassa Even betulinic acid, a pentacyclic triterpenoid, can bind to both CB1R and CB2R Falcarinol, found in many plants of the Apiaceae family (Daucus carota specifically), exhibits binding affinity to both CB1R and CB2R but selec-tively acts as a covalent inverse agonist in CB1R Polyphenols: Biochanin A has cannabimimetic activity seems linked to inhibition of fatty acid amide hydrolase, an enzyme for anandamide degradation A growing body of evidence suggests that anthocyanins incl. cyanidin may have analgesic, neuroprotective and anti-inflammatory properties, and these biological effects are tied to its potential action on cannabinoid receptors. Cyanidin is a ligand with moderate affinity to human CB1R and CB2R There is moderate affinity of catechins to CB1R. Curcumin is an antagonist/inverse agonist towards CB1R but contradictory results have been also produced Magnolol showed a profile of partial agonist with selectivity for the CB2R, while honokiol possesses a signifi-cantly lower affinity for the CB1R The cannabimimetic action of kaempferol may be due to its inhibitory capacity towards the FAAH degradation enzyme. Quercetin, a flavonol associated with rutinose to form the glycoside rutin, showed an upregulation of CB1R Maca - Lepidium meyenii - has action on the endocannabinoid system N-alkylamide lipids show structural similarity with anandamide and bind to CB2R more potently than endogenous cannabinoids. N-alkylamides have been isolated from Echinacea purpureaand Echinacea angustifolia. Moreover, other extracts of Echinacea spp. have demonstrated anti-inflammatory property by PPAR activity. Even Otanthus maritimus (family: Asteraceae) possesses N-alkylamides with a good CB2R affinity
  9. Anyone else gone and planted a few common Camellias for tea purposes? It's quite debated whether non-sinensis teas are caffeine/theanine containing but those who have made tea from it often say it seems more potent. I like to have a mutual living relationship with the medicine I'm using - not simply a commercial consumptive one - so will plant a few common (related) C. japonica which can be used to make tea It, according to some, contains caffeine and catechins of the same kind as C. sinensis but "Japonica seems much more potent, even when processed as green tea." with >5% per weight caffeine in dry leaves but "..not all cultivars will be equally potent" [1] (another study on the contrary found no caffeine [2] and some say the "entire series of reactions required for the synthesis of purine alkaloids was deficient in both C. japonica and C.sasanqua". ) and triterpenes, flavonoids, tannins and fatty acids. It has 42% of C. sinensis' theanine compared to Camellia sasanqua which is slightly higher [3] [1] http://www.koreascience.or.kr/article/JAKO200403042358213.page [2] http://dx.doi.org/10.1270/jsbbs1951.34.459 [3] https://www.tandfonline.com/doi/abs/10.1080/00021369.1984.10866604 Explorations into the effects of tea on behaviour and mental health come at a time of growing scientific interest in the role of nutrition in mental health and preventive medicine. Physicians need more ways of tackling anxiety, depression and age-related cognitive decline — these conditions place a huge burden on health systems, and treatment options are limited - due to the lack of available therapies — around one-third of all people with anxiety and depression never find an effective therapy [1] Tea is on the rise, because so is stress. It embodies mindfulness and the serenity that a lot of stressed people need in their lives, along with being connected to emotions, and promotes a calming sensation for many drinkers [2] [1] https://www.nature.com/articles/d41586-019-00398-1 [2] https://www.sbs.com.au/food/article/2019/03/20/tea-drinkers-are-better-people-and-probably-less-stressed-too
  10. That was beautifully written @mysubtleascention I like the mention so often of harmony - that's a wonderful way to put it. Thanks for sharing.
  11. Alchemica

    Alcosynth - Safe alcohol alternative?

    Yeah I get you on that, it's sad that's the way things are for so many - I too sought the void all too often as life felt totally futile and full of pressures I couldn't handle. I've had to essentially disconnect from the majority of the ways our society runs, which isn't doable for everyone, as it is simply really bad for my health and not feel too guilty about it, the other way was literally killing me way too quickly Thing is, I got a 'safer alcohol substitute' like pregabalin (don't mention the way phenibut went) and tried to use that instead of drinking and got blatantly addicted to it. Dose escalations. Tolerance and withdrawals. These things, if they offer any sort of nice effect, they will have abuse potential and really serious potential for harm away from being not that damaging in themselves - eg people operating heavy machinery is just one I feel if many people got a clean break from drinking even to socially normal levels, ie a good period of total abstinence going, they'd find themselves in a better place where they didn't have to get persistently blasted by anything. So many., even those doing socially acceptable drinking, are in the cycle of use-withdrawal that they don't know what they feel like without it in their lives, which is scary. It really is such a nasty substance for mental health, for spiritual growth for everyone and society. They could too become teetotallers getting bent on a wholesome cup of tea etc I'd rather some decent kava be allowed in, or something planty that could build up a responsible culture of use around it. But while people are used to getting inebriated as culturally accepted there will be issues
  12. Alchemica

    Alcosynth - Safe alcohol alternative?

    Yeah originally they were looking at pagoclone but it could be any α-subtype GABAA targeting drugs/PAM But really, this is another cultural symptom... sure it may be safer than ethanol but seeking such a quick fix is a consequence of a problem, not a solution This was once my Holy Grail quest - to have a safe alcohol substitute/pro-social aid through through things like this Then I noticed how empty mere anxiolysis was. Spiritually devoid. It had no ability to grow you into your Divine Self, it just let you run away Sure, there's severe pathological anxiety which I know is all too crippling but we need more wholesome tools that allow one to be themselves. I still feel plants offer a better tool to return to wholeness. Sure, they may not offer blatant inebriated anxiolysis but that's part of the challenge I feel, to be comfortable with things like anxiety until they no longer over-power you. We need to consider why people are seeking such anxiolysis and feed their spirit to a place where they can have calm loving self-acceptance and compassion, not allow them to run away with another vice. For me, this weekend I could go out... but in all honesty I'd rather not. eg in our society, you have to be absolutely off your head to find the majority of people interesting enough to even be interested in having a convo with them thanks to their cultural conditioning...
  13. There could possibly be some changes but in my non-professional opinion, nothing dangerous. Best checking with professionals though. You have to consider your changes to self-concept too which would also impact the journey There is a strong modulatory influence of estrogen on the serotonin system: there seems to be cross-talk between estrogenic and serotonergic pathways "ovarian steroids bring induction of dendritic spine proliferation on serotonin neurons [with a ] profound effect on serotonergic transmission. " [1] ERβ negatively regulates 5-HT2A [a phytoestrogenic diet caused a significant decrease in the expression of 5-HT2A receptors ] and estrogen changes this receptor binding There is support for the effect of progesterone on 5-HT1A receptor expression by affecting the serotonergic system supporting "relation of the steroid hormone progesterone to 5-HT1A receptor binding. [2] [3] There could be some changes to CYP liver enzymes, too - this would alter how quickly things like beta-carbolines stayed active
  14. Thanks for sharing. I used to just aim to get loose on loose leaf tea. Then I noticed how potent a healing aid it was on a different level... Tea has powerful spiritual and ceremonial role - I'm not sure I'd go as far as soma but it's a potent ally. Tea mystics are spiritual psychonauts “Tea is Nature… Tea is Medicine… Tea is Heart and Spirit…” Tea is something that can help you forward in meditation, mindful absorption of the present, and self-cultivation. The Way of Tea is expressed in four Japanese characters: Harmony, Respect, Purity and Tranquillity “It’s hard to even speak now ‘cause that was so profound, and I don’t know that words are really poetic enough or descriptive enough, but I really felt — I feel different from the moment I started ’til the end; I really felt like I went through a journey.” [1] "Having been under the influences of rapid infusions of some 1950’s Red Mark Yin-Ji Puerh I feel justified in suggesting tea or Camellia sinensis as a possible candidate or substitute for Soma. With tiny orbs of qi coursing through my system after each sip I see a vision of the lineage of patriarchs of Esoteric Buddhism and thangkas of blue Bodhisattvas holding cups of amrita in their palm. Tea may not be the original soma, but the reverence, ritual and perhaps the shape into which it is pressed (especially in Tibet), make it a serious candidate as a soma-substitute or amrita." Tea "as a beverage that, when ritually prepared, allowed communion with divinities—suggest the reason for continued appeal in later ages in both China and Japan”. Tea’s constant domain within a sacred, often ritual context must be always remembered and it is retained even in the more secular literati circles that treated it as a near sacrament in their microcosmic ways and arts. "Tea’s special relationship with Buddhist and Daoist “ritual”, or combinations thereof, and persistent associations with Indian mystics and religious experience were instrumental in the spread of tea throughout ancient China, Korea and Japan." [2] There's much to be explored in a porcelain cup of alkaloids - we do not always think of tea as a potent psychoactive plant in the West, as it is so commonly consumed and readily available. One becomes liberated from earthly attachments and is able to commune with eternity, nature, and all living beings - a path to the essential self [1] People note a sense of well-being and peacefulness and appreciate the little things and not rush Erowid Tea "The effects were stronger than I expected. I hadn't had tea in awhile. Sounds around me were amplified. The wind was pressing against me. I felt like I had taken a strong sedative. My body felt heavy. The wind itself felt euphoric and I felt butterflies through out my body. I had a strong since of well being. The world was beautiful, the trees swaying in the wind were happy/excited. Every living things Qi/soul whatever you want to call it were reaching out to my soul/energy and intertwining. Almost like drinking the tea allowed me to shed energy blockage which was keeping us from connecting. We were friends. The birds chirped beautifully. I felt inspiration and connection to the earth. I was ONE and felt love!" "Vision crisps up ... more vibrant, bit sharper. Euphoria. ... It was an amazing time, carefree in the warm summer sun, fueled by fusion, almost god-like. There was no comedown, it simply ended. I would honestly consider that day a +++ on the Shulgin scale comparable to mushrooms." People have touched on the social, spiritual, and health benefits, noting that it opened one’s mind to the higher things. It encouraged quiet meditation, rustic simplicity, aesthetic judgement, appreciation of nature, and the significance of the present moment. It also necessitated “courtesy ... moderation in actions,” and purity of spirit [3]. Some assert ...the practice of tea will make you friendlier, kinder, and more concerned with serving your fellow human beings. In other words, the plant Camellia sinensis and its related Camellia species will make you into a better person. “茶禅一味” which translates to something like “Zen and Tea — the same taste.” In other words, consuming tea are both viewed by some as spiritual expressions [1] https://www.reddit.com/.../understanding_tea_mysticism.../ [2] https://sites.google.com/.../delawaretea.../Home/tea-as-soma [3] https://www.crisismagazine.com/2012/tea-and-christianity Ritual use of plants incl. tea
  15. One ally that has been instrumental in me getting past vices is this common one which I think is totally underrated. I find my simple tea is so healing and you don't need to drift off to fancy teas all the time! Some tea drunk suggestions from others Tea - A passage to spiritual harmony Epidemiological investigations have reported that drinking tea reduces the risk of dementia and depression. Research suggests that tea catechins, mainly EGCG, elicit cognitive effects as well. EGCG administration has been associated with self-reported calmness and reduced stress in healthy subjects. It showed beneficial effects in related areas such as work performance and creativity [1]. Tea use was associated with reduced stress, increased calmness and increased electroencephalographic activity (increased alpha, beta and theta activities) in the midline frontal and central brain regions Green tea consumption in subjects with cognitive dysfunction (2 g/day for 3 months, approximately equal to 2 to 4 cups of tea/day) significantly improved cognitive performance. Along with the effects of lower doses of caffeine and small quantities of L-theanine, EGCG has sedative effects in the brain, partially through GABAA receptors, and consequently moderates an acute stress response in a dose dependent manner. With the feelings of euphoria, there can be a strong sense of focus and calm. Tea drinkers may experience acceptance of the world, a feeling of contentment, and pleasing lightheadedness or sense of floating. Others list symptoms such as a giggling, a bouncy feeling, a feeling of emotional bliss, a contemplative or philosophical mindset, or an introspective, sensitive mood. The overall effect is often described as a very Zen feeling. ...get in a mindset of focused observation of the physical, mental, and emotional/spiritual effects of the tea [ref]. EGCG may reduce the negative mood effects of caffeine in a similar manner to L-theanine. Several studies found that caffeine and L-theanine improve attentional performance but studies did not find any change in self-reported mood compared to caffeine. Some of the studies, even on more well-known combinations such as caffeine and L-theanine, failed at reproducing the same results as in other studies. L-theanine appears to be most beneficial in subjects that reported being more stressed and/or anxious during the study. Tea catechins have GABAA modulatory [2] and cannabinoid affinity [3] and tea consumption might reduce antipsychotic-induced side effects. While the tea catechin EGCG is known to inhibit COMT enzymatic activity in vitro this may not be relevant in vivo EGCG attenuates NMDA antagonist-stimulated behaviours "Much of orally ingested EGCG is hydrolyzed to epigallocatechin (EGC) and gallic acid. In rats, EGC is then metabolized mainly to 5-(3',5'-dihydroxyphenyl)-γ-valerolactone" These metabolites may promote neurogenesis in the brain [4] As ligands for the GABAA receptor benzodiazepine site, the higher catechins like EGCG being PAMS at some sites. EGCG reversed the effects of GABAA receptor negative modulators - picrotoxin and methyl beta-carboline-3-carboxylate, EGCG and chlordiazepoxide fully generalised in substitution studies. The phenolic acids are also GABAergic, potentially at different GABAA subtypes. Polyphenols and L-theanine for stress: Black Tea - regular consumption of black or oolong tea was associated with lower risks of cognitive impairment and decline "Following plants trends and rituals that don’t come from your personal lineage harms those who rely on such plants, especially colonized people, and the plants themselves (by overharvesting). Moreover, this routine does a disservice to your health. There’s no reason to chase plant wisdom outside your lineage for meaning - we miss out on a chance for a more genuine connection with plants already deeply rooted in our family histories by following plant trends that fall outside our lineage." [1]. There's lots of research around green tea/EGCG and theanine but "Theaflavins, black tea polyphenols, effects on brain function, especially mental condition, have not been elucidated". Recently there's been a bit. Oral administration with theaflavins can suppress neural inflammation and prevent inflammation-related brain disorders, improving memory impairment and depression-like behaviour [2]. Theaflavins from black tea have a stronger anti-inflammatory effect than many other polyphenols. Oral consumption of theaflavins induced anxiolytic effects via activation of the dopaminergic system in the frontal cortex [3]. Despite concerns about these reaching the CNS, oral doses are indeed CNS active in animal models. A standard cup of black tea was found to contain L-theanine 24.2 ± 5.7 mg and mostly thearubigens contrary to a cup of green tea which contains ~8mg theanine and ~70 mg EGCG per bag. That said, one study claims green tea was more effective for neuroprotection than red and black teas. One paper states black tea polyphenols are more effective than green tea polyphenols in body weight reduction [4]. Theaflavins are "promising functional food ingredients and medicines for improving insulin resistance-related disorders" and improve postprandial glycemic control [5,6]. Black tea possesses "marked aphrodisiac activity" and "can function as a quick acting, safe, oral aphrodisiac" [7]. [1] https://www.healthline.com/health/plants-as-medicine-history [2] https://www.ncbi.nlm.nih.gov/pubmed/30696093 [3] https://www.ncbi.nlm.nih.gov/pubmed/30806570 [4] https://www.ncbi.nlm.nih.gov/pubmed/27941615 [5] https://www.ncbi.nlm.nih.gov/pubmed/30572687 [6] https://www.ncbi.nlm.nih.gov/pubmed/28049262 [7] https://www.ncbi.nlm.nih.gov/pubmed/18565706 Green Tea Improves “cognitive functioning [through affecting]…working memory processing at the neural system level by suggesting changes in short-term plasticity of parieto-frontal brain connections.” Beneficial for it's stress resistance, and neuroprotective and autophagy-promoting properties Green tea might reverse the development of depression through normalisation of the reward function. Green tea is promising for neuroprotective/neurorescue activities in a wide array of cellular and animal models of neurological disorders and is suggested as a prophylactic for Alzheimer's, Parkinson's etc - higher consumption of green tea is associated with lower prevalence of cognitive impairment A retrospective study with 278 consecutive Parkinson's patients reported that consumption of more than 3 cups of tea per day delayed age of motor symptoms onset by 7.7 years and green tea polyphenols provide a symptomatic benefit in Parkinson's Green tea is believed to lower the risk of dementia both through it's polyphenols and active metabolites that exhibit effects on nerve cell proliferation and neuritogenic properties. The consumption of green tea catechins is generally believed to suppress age-related cognitive dysfunction, The neuroprotective, antioxidant, anti-inflammatory, and iron-chelating properties of EGCG make it promising for neurorescue. Diet induced neuroinflammation was restored by EGCG supplementation and homocysteine-induced neurodegeneration and neuro-inflammation in the brain was attenuated. It inhibits brain damage and promotes regeneration in the cerebral cortex of rats. It shows promise for Down syndrome and is a TLR4/MyD88 antagonist and inhibitor of DYRK1A EGCG was able to effectively inhibit volatile anaesthetic-induced neurodegeneration and improve learning and memory retention, which is relevant to my case. There is evidence of hepatoprotective [see more - note high doses have been linked to rare hepatotoxicity] and restoration oxidative-nitrosative stress-mediated apoptotic signalling in cognitive deficits associated with alcohol Teas significantly reduced AChE activity and partially reduced fat accumulation. Green teas reduced memory deficits. They reduced reactive species accumulation and reduced plasma triglyceride levels. The tea polyphenol EGCG has been shown to ameliorate metabolic abnormalities and fatty liver. Some evidence suggests that daily consumption of tea catechins may help in controlling type 2 diabetes Green tea is promising for different neurodegenerative conditions, such as memory deficits. EGCG-treated rats displayed a superior behavioural performance and it enhances neuroregeneration after injury via alteration of levels of inflammatory cytokines. Green tea was more effective for neuroprotection than red and black teas. Green tea's theanine seems to have multiple beneficial effects on depressive symptoms, anxiety, sleep disturbance and cognitive impairments in patients with major depression [4] It may be beneficial in schizophrenia [5] Review Oolong contains more O-methylated catechins like (-)-epigallocatechin 3- O-(3- O-methyl)gallate with distinct physiological functions in animal models and humans compared to common tea, including antiallergy, antiobesity, the prevention of cardiovascular disease risks [review] Pu-erh tea fermentation forms simple phenolic acids (gallic) and theogallin while epicatechin, epigallocatechin gallate and theanine decreased during fermentation [review] It is reported that Pu-erh tea have a variety of pharmacologically activities, such as anti-hyperlipidemic, anti-diabetic, anti-oxidative, anti-tumor, anti-bacterial, anti-inflammatory, and anti-viral effects. It is promising for it's effects on metabolic syndrome through remodelling the microbiome Pu-erh tea contains "biological compounds binding transcription factors and inhibiting the expression of mGluR5 and is a novel natural neuroprotective agent" as dysregulation of mGluR5 is implicated in multiple brain disorders particularly showing promise for pain, epilepsy, schizophrenia, drug addiction and Alzheimer’s disease Gallic acid in Pu-erh tea is reported to be a main constituent. This has neuroprotective, antidepressant [1] and anti-psychotic acitivities [2] It is also a rich source of other benzoic acid derivatives, phenylacetic, phenylpropionic, phenylvaleric and phenolic acid esters [3] Host your own healing tea ceremony Sure, there's 'recreational tea sessions'. There's also healing tea sessions When practised to foster harmony in humanity, promote harmony with nature, discipline the mind, quiet the heart, and attain the purity of enlightenment, the art of tea becomes "teaism" [1] It can re-inforce harmony of nature and self cultivation: refinement, an inner spiritual content, humility, restraint and simplicity Tea invites us to connect with nature, with our community, and with the deepest parts of our unknown selves. I believe if you dedicate your time to one plant such as Camellia sinensis, you can form a really therapeutic ally and it's often the easily dismissed plants that can bring us to where we need to be... I feel tea brings us back to better holistic health and spiritual harmony - you often don't have to be fancy and chase a multitude of exotic plants and potions. It turns into a wild goose-chase It's sacrilegious the way we as a culture make it about "a quick mediocre cuppa" when it's healing properties for the body, mind and spirit are so notable [1] https://en.wikipedia.org/wiki/Tea_ceremony Spirituality of Tea "I got nasty habits; I take tea..." - Mick Jagger "Tea is part of the spiritual activities of being properly engaged and aware, both of self and others. As J. Norwood Pratt relates: As an elixir of sobriety and wakeful tranquility, tea was also a means of spiritual refreshment and spiritual conviviality, a way to go beyond this world and enter a realm apart. Tea was an aid in Christian temperance. Tea is an equaliser, the approach to tea as an aid to meditation, and the emphasis on beauty in simplicity. It allows a Daoist concept of returning to a state of rustic simplicity. "Tea seeks social harmony through self-discipline and personal discovery and personal desire for salvation. Whereas Tea requires a degree of contemplation of, and concentration [it also] invites the participant to look into himself or herself, to discover a self that is no longer separate and potentially antagonistic but in harmony with the environment and all others. “I” and “Thou” are able to merge, where the “Thou” becomes the “I” and vice-versa. The distance between self and other, which upholds life in normal times, disappears in favor of unity. “I” and “Thou” become “we,” a “we” established and strengthened by ritual Freedom is sought not in large space or in unrestricted behaviour but, on the contrary, by accepting and “overcoming” restrictions. There is freedom through meditation and other forms of self-discipline. It invites humility, that is, a negation of self in the absorption in something else as expressed in the Buddhist notion of muichibutsu. This concept can mean many things. It points to the Buddhist notion of “nothingness,” “emptiness,” or the original unity of all things. ...tea is at once the center of the universe and a means to harmonize with the essence of things." [2] [1] http://walkerteareview.com/spirituality-of-tea-buddhism-ch…/ [2] http://anthropoetics.ucla.edu/ap0501/tea/ Other methylxanthines and synergies Theobromine may selectively enhance caffeine psychoactivity - increased “energetic arousal” as well. In terms of mood effects cocoa flavonoids may modify caffeine's psychoactive effects in a similar manner to L-theanine. Experiments found that combination of cocoa extract and caffeine attenuated the anxiety-provoking effects of caffeine alone Evidence for an improvement of executive function 90–150 min after the administration of cocoa flavanols. Caffeinated cocoa (70 mg caffeine, 179 mg theobromine, 499 mg flavanols) caused lower omission errors and improved accuracy in healthy subjects compared to cocoa alone (21 mg caffeine, 179 mg theobromine, 499 mg flavanols), but attentional performance was not better