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  1. Today
  2. I reckon I could make that weekend.
  3. Some disjointed thoughts... Just curious - have you used the glycopyrrolate wipes? Afaict it’s used for this purpose over other antimuscarinics (AM’s) not only because of the blood-brain barrier thing, but also because it’s selective for M3 receptors - the kind involved in peripheral gland stuff. Whereas most (all?) of the naturally-occurring compounds have some central activity & are considered “non-selective” (this isn’t 100% accurate, but they’re at least *less* selective). And leaving aside the central effects, you can also expect peripheral side-effects like dry mouth & eyes. Glycopyyrolate is also significantly less lipophilic than the 2 most common naturally-occurring AM's (atropine & scopolamine) - and so is better suited to topical application, as it's more inclined to stay put & not go sneaking off over membranes to cause mischief elsewhere in the body. Don't be put off by the title, the intro of this paper: Pharmacokinetics and Pharmacodynamics of Glycopyrrolate in the Horse (2012) gives a good rundown of the general history/chemistry of various AM's and how this has informed their applications. Take the literature about reduced side-effects with different tropane ROAs with a grain of salt: eg. you will read claims that transdermal scopolamine has less central/adverse effects than oral, but a large part of that difference lies in the slow release & therefore lower peak drug levels (ref) - it’s not necessarily to do with the route per se. Also, if you’re aiming for something like the glycopyrrolate wipes, then you actually want local activity without absorption (i.e just the “dermal”, minus the “trans-“), and not many papers make this distinction between topical/transdermal. If you do make up a topical cream, some stuff to keep in mind: - make a large batch (so you can standardise a dose properly - atropine & hyoscine are quite heat-stable & should keep a long time if the base itself is stable) - make sure it’s homogenous (tropanes are potent, you don’t want any pockets of cream that are 10x as strong) - use an aqueous base (you’re aiming for local activity, not transdermal absorption - so no DMSO, no oily salves) - alternatively, make up an aqueous solution to apply via wipes/spray: a patent for glycopyrrolate wipes settled on 10mg (oral dose is 1-4mg/day) dissolved in 1ml of 33% EtOH in water (eg. vodka) for each wipe - so maybe you could use those ratios as a rough starting place? The patent discusses some of the issues with consistent dose/applications via this method & how they addressed them - don’t drive (possibility of various CNS effects, also a common side-effect which impairs your eyes' ability to focus) - be aware of the half-life & other metabolic issues relating to the active ingredient(s) - half-life can be *long* for some of them (I mean both: some actives & some effects) so that you might get some cumulative effects even with once-daily dosing; and pharmacokinetic variations can be major (not just between individuals, but also individual responses at different times) and involve a lot of factors - not least the many, many drugs that might have significant interactions. - many people get mild skin reactions from topical AM’s (esp. with repeat applications) which can also affect absorption (irritated skin has higher bloodflow, lower barrier effect) So that's how I'd be starting as far as prep was concerned. But now let's backtrack & consider whether this is actually a good idea. This class of drug is used to treat excessive sweating, that is true. But that use is generally limited to pretty severe cases - e.g. where disease/surgery has impaired their autonomic nervous function (to the point where their hyperhidrosis is causing dehydration or problems regulating body-temp). Another main use is in palliative care for terminally ill folks who aren’t concerned about long-term side-effects and just want to be free of their “death-rattle” & have some dry sheets before they die. And even in these cases, many patients choose to stop taking their meds due to the side-effects. A potential risk of any kind of regular long-term use is the possibility of “cholinergic rebound” when you stop. There have been cases where people taking scopolamine for motion-sickness got withdrawal syndromes after only a few days to a week of daily use (includes transdermal use). That side-effect seemed to be only temporary & could be managed by tapering down off the drug, but definitely proceed with caution here. Sweating is pretty important in regulating body temperature, and if your body thinks that system isn’t working properly it might try to compensate. Compensatory hyperhidrosis seems to be a major issue after sympathectomy surgeries (sometimes used as a last-ditch treatment for severe hyperhidrosis) - and while that specific mechanism mightn’t apply here to AM drugs, there might be some equivalent one. Even in the short-term, your actual intended effect (of reducing sweating) alone can be dangerous - people on AM’s have increased risk of hyperthermia, and need to monitor their body temp manually to make sure they aren't overheating. Especially if hot weather &/or physical exertion are going to be involved, please use extreme caution when experimenting with this. For eg: try treating only some areas of skin, carry a thermometer to monitor your body temp, be sure to continue using other basic cooling methods as well, and make sure you have plenty of water & some method of rapid-cooling (ice-packs, cool creek to jump into, etc) in case of emergency - heatstroke is a miserable experience. Also be triply-cautious when combining with any psychoactives known to affect temp-regulation... MDMA in particular is a big one there. The researchers who were looking at treating hyperhidrosis in physically-active patients were concerned even about the effects of caffeine! - and while that might be overkill (for regular ambient temps & activity levels anyway), it does at least give you an idea of the level of awareness & attention to detail you want to have going into an experiment like this. I'd be less worried about a tropane OD, and more concerned that you're taking away a fairly major safety net that we don't often have to think about. Even if you're only removing part of that net, it's still an important function that you probably should try to replace with conscious monitoring (like those poor people that can't feel any pain who need to keep visually checking all their body parts to be sure that their hand isn't resting on a hotplate or something). Not wanting to over-dramatise or exaggerate the risks here - this isn't necessarily a risky thing on its just has lots of ways it could become risky. But if you're mindful of the potential, and proceed patiently & with caution I think most of those could be minimised? Other options that spring to mind: deodorants based on bentonite clay; washing with witch hazel (or other herbal astringents), &/or vinegar; physical cooling (apparently just drinking a slushie can lower your core temp by ~0.5 C & reduce sweating, for a while at least). Another thing you could try maybe is hyoscine butylbromide (available OTC), which is sometimes used for hyperhidrosis as it’s a form that’s blocked by the BBB. Or if you want a DIY experimental treatment, how about tap-water iontophoresis - looked more promising & less risky? Here are some refs, the last one has instructions for a DIY apparatus: http://Treatment of Palmar Hyperhidrosis with Tap Water Iontophoresis (Kim et al, 2017) Long-term efficacy and side effects of tap water iontophoresis of palmoplantar hyperhidrosis--the usefulness of home therapy (Hölzle & Alberti, 1987) A Simple User-made Iontophoresis Device for Palmoplantar Hyperhidrosis (Nagar & Sengar, 2016) And if you find that the iontophoresis isn't effective enough on its own (i.e. just w/plain tap water), it has also been used to facilitate dermal delivery of drugs (eg. glycopyrrolate solution) - so you could always add some brug drops to the water later on for a double-whammy? And just as a general safety note for handling plant tropanes, (especially any kind of extract/concentrated form) - remember that they are absorbed through the skin & use appropriate caution: don't handle with bare hands, clean up any spills & wash/mop the area afterward, make sure everything is clearly labelled, and so on. For solutions I'd consider adding some kind of coloured dye to make spills more visible (only because invisible spills would worry me more than stained skin). If experimenting with solution/wipes, I'd also wonder about the possibility of any excess/unabsorbed actives getting absorbed by my clothes - not sure if/how they address that with the glyco-wipes? maybe it's not a problem - but I wouldn't be asking anyone else to wash my clothes until I knew the answer.
  4. Does anyone have any experience (or anecdotes) with regard to A suaveolens? I have been keeping an eye on them in the local reserves/roadsides and now they've flowered and been identified, wondered if anyone has put them to use. They grow fast but sparse and spindly. I will be collecting seed too in a few months once they've set pods, if anyone's interested in some.
  5. Have some fresh seed for sale. All you need is host trees (and a lot of time) Can fix approx 1kg in a mailing box. This is about 150-200 seeds $35 (shipping and tracking included)
  6. ^ Sounds good
  7. Trippin'
  8. I've heard Turbina is almost indistinguishable from LSD (Gotta get my hands on it ;) )
  9. This reminds me of the work of 69ron. I've read a lot on the topic and I'm yet to be convinced these conversions work. Turbina is far superior in my meagre experience.
  10. Just found this: it looks incredibly promising
  11. I've never tried turbina corymbosa, is the chemical makeup that different?
  12. Have you tried turbina corymbosa seeds instead in an acidified cwe?
  13. Gimli your generosity knows no bounds I have a fair bit going on, in the spring i will put together a few seedling packs for this purpose : ) Great idea you have here, hopefully you will get some comrades to join the project : )
  14. I can help you with the wormwood.. give me a pm and we will work something out..
  15. Ethnopharmacology of Love Background: Elixirs conferring eternal youth or inducing amatory and erotic attraction have been searched for without success. Lovesickness is a widespread affliction resulting from unrequited love and/or the impossibility for physical and emotional union. The symptoms are reflections of altered dopamine, serotonin, noradrenaline, testosterone and cortisol levels and range from frenzy and intrusive thinking to despair and depression, sharing traits with the neurochemistry of addiction and compulsive behavior disorder. Although it can seriously impact the quality of life, lovesickness is currently not considered in official disease classification systems. Consequently, no official therapeutic guidelines exist, leaving subjects to seek the cure on their own. Methods: We review literature of the past 2000 years dealing with the concept, diagnosis and the healing of lovesickness and contextualize it with neurochemical, ethnomedical, and ethnographic data. Since neurobiological and pharmacological connections between the love drive and the sex drive exist, we review also the literature about herbal an- and aphrodisiacs, focusing on their excitatory or calmative potential. Results: An overall consensus regarding socio-behavioral regimes exists for dealing with lovesickness from historical through contemporary literature. The herbal drugs used for treating lovesickness or inducing love passion do not possess the alleged properties. The pharmacological effects of aphrodisiacs are heterogeneous, including dopaminergic and adrenergic activities, but there is no evidence for any serotonergic effects. The libido-regulating properties of anaphrodisiacs seem to be associated with sedative and toxic effects or decreasing testosterone levels. CB2 receptors expressed on dopaminergic neurons of the ventral tegmental area, part of the brain’s reward circuit, implicated with addiction, orgasm and strong emotions such as love, might constitute a new therapeutic target. Conclusion: The common food additive and CB2 agonist β-caryophyllene might have the potential to attenuate dopaminergic firing, quenching the reward and thus motivation associated with romantic love. From Greek mythology to modern history, cultural expressions and implications of love, sex and procreation is and was organized along hierarchical lines that put men on top. The neuronal predispositions and activities associated with falling in love will probably forever remain nature’s and Eros’ secret. Copaiba oil, ~50% β-caryophyllene, appears safe orally at low doses An update on the pharmacology of BCP - orally active potent CB2 full agonist and PPARα/γ agonist. - Analgesic, anti-inflammatory, anti-amyloidogenic, insulin-sensitising, anti-alcoholism, anti-cancer, cardioprotective, hepatoprotective, gastroprotective, neuroprotective, nephroprotective, antioxidant, antimicrobial and immune-modulator effects - Exerts anxiolytic and the anti-depressant effects via CB2 agonism - Activates TrkA receptors and induces neuritogenesis by a mechanism independent of NGF or cannabinoid receptors - potent antagonist of α7-nAChRs - exhibits synergy with µ-opioid receptor dependent pathways - Neuroprotection via prevention of microglial activation and inflammatory cytokine and chemokine expression: β-caryophyllene reduced astrogliosis and microglial activation as well as the levels of COX-2 protein and the mRNA levels of the proinflammatory cytokines tumor necrosis factor-α and interleukin-1β in the cerebral cortex, inhibits pathways triggered by the activation of toll like receptor complex - CB2Rs modulate striatal dopamine release - PPARγ activation prevents the negative emotional effects of stress and exerts anxiolytic actions - CB2 agonists may provide therapeutic possibilities to treat metabolic diseases associated with lipid dysregulation. β-caryophyllene is an attractive molecule with therapeutic potential for the treatment of pain, Alzheimer's disease, anxiety, depression, Parkinson's, schizophrenia, various neurodegenerative conditions, brain injury, diabetes and metabolic disorders
  16. Yeah, feel you on that, sorry to hear things are a struggle for you. I got disconnected again and the only way I've recently been able to reconnect is through plants. It takes my head off the social situation which is hard to manage with anxiety, social anhedonia and not finding common ground etc. Churned out a bunch of Ashwagandha tubestocks through winter that did well in the greenhouse, ready for spring. Joined the local grow free group. I've been forcing myself to connect with new people, even strangers, by giving the plants away. It just makes an awkward social encounter more positive. A reason to try. Just breaking that pattern of isolation through a plant can be potent. You can rebuild some social skills etc. Transfer interests from one domain to another etc
  17. Da Fuck I miss this..... Excellent info It's hard to be on top of your game when ya feel in shit. Sometimes your gotta go with it and at other times grasp it and say Fuck it and take it matter how Rinse and repeat. Keep the fire burning....
  18. I can't right now as I'm really low and lost a heap I neglected. But I can once I dedicate some time to building up a heap of plants again
  19. Hi. Gimli.. I may be able to help you out in the near future..
  20. @bardo Lol... That was to escape the Lego Marvel super heroes game
  21. Maybe have a go at the method i mentioned, you are right in your impression tho, i believe this method does mitigate some of the unpleasantness but unfortunately even with this method the side effects are still pretty pronounced. I think they are worthy of experimentation and occasional usage and can certainly have pretty awesome and memorable qualities but with that said i think there are many things equal or better with far less discomfort to endure.
  22. yeah, give me a holla...
  23. Well that's the whole point isn't it, painting a grim picture. Whatever picture they are painting though it's not real, as in fake, as in computer simulation. It's fine not to be smart but please just stop spewing your dumb shit here Man it's not my "dumb shit" it's from nasa. So you think nasa has a task of painting a grim picture rather than present data ? If you don't know what carbon dioxide breaks down to without googling it then maybe you don't know as much as you think, if you do then perhaps in this case your ignorance is willful. Do you know what feedback loops are ? what about albedo effect ? you know that salt water freezes at lower temps than fresh water ? There is no issue, there is only an issue if you care about the continuation of multi celled organisms That's meteorology not climatology, climatologists don't make models based on predictions they use data to make projections.
  24. 11:11 Your generosity and service to other selves hasn’t gone unnoticed my friend. Keep up the good work Gimli.
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