Bought myself a new ally, a Magnolia grandiflora tree.
The flower contains liriodenine, anonaine, dehydroremerine (0.52% total alkaloids)
Leaf from the flowering plant contains anonaine, remerine, liriodenine and rutine (0.54 % total alkaloids) It also contains essential oils 0.58 %
Anonaine, the principle leaf alkaloid displayed affinity of 0.8 µM, the same order as the reference compounds nomifensine (0.2 µM), but more potent than amineptine and dexamphetamine at DAT. The oxoaporphine liriodenine was virtually devoid of activity as a dopamine reuptake inhibitor. It also has affinity for 5-HT1A and α1 adrenergic receptor affinity. Although not overly potent, studies suggest they are α1A antagonists, as is demonstrated by the vasorelaxant responses. The flowers are edible and said to have an exquisite flavour and are used as a spice and condiment. My flowers were dried and aged on the plant so lost most of that but still interesting flavours. Volatile constituents are mainly monoterpenoids and sesquiterpenoids. Look forward to a tea from the fresh flowers. Interestingly, the crude extract of the seeds contains 10% 4-O-methylhonokiol. It is also found in the bark. This is a potent CB2 receptor ligand which readily crosses the blood brain barrier and attenuates memory impairment. In addition to anonaine, liriodenine etc, the leaves contain sesquiterpene lactones like parthenolide which has intriguing activity but low bioactivity.
Please be aware that the toxicity of the leaf material is unestablished while the constituents are more characterised. Well the Magnolia flower tea was interesting tastewise maybe a slight subjective uplift. Something spiritual to it but I wanted more DAT/5-HT1A action. Chewed through a whole flower as tea.
Wanted to develop a bit of a relationship with this plant, see if it could be a good functional motivational aid, so I tried 2 tsp dried leaf material on top. Struggling to find info on doses but the same alkaloids at 5-10mg/kg in mice exhibited antidepressant activity. For me, the upper alkaloid dose would be about 80mg alkaloids in human equivalent doses. Interesting resonance, seems somewhat useful for doing things. Soft energetic resonance, seems superior to lotus/lily. Not really stimulatory but functional it seems. 3 tsp of crushed dried leaf: need all the uplift I can get. There's something but it's not pushy stimulant wise, feels clean, a focusing energy but soft. Started another day with leaves 17g dried, ~ 90mg alkaloids. I had to have an early sleep on it, it seems to have some waves of calming sedation for me anyway. Then it picked up into something more 'wanna do stuff'. Followed that up the next day with 17g and I had quite a good day. I tend to find stimulants calming and de-scattering so results may vary. I do like the magnolia leaf at decent doses but I'm going to leave my experiments there, let my ally grow before I find it too useful. Wouldn't say it's going to make a magnolia crack but still interesting. If I find a large M. grandiflora, I might make magnolia leaf extract, the tea is quite unpleasant and it would be nice to have a concentrated extract. Anyone done any trials themselves?