Auxin Posted November 22, 2006 Cleaned Withania somnifera seed is listed as a hypnotic sedative but I have yet to find any dosage information or bioassays. Has anyone experimented with the seed or read reports on it? I harvested and cleaned a crapload of seed and despite giving them away by the thousands at every opportunity I can tell I'll still have alot left over. Perhaps they have an alternate use? Share this post Link to post Share on other sites
sascacheuan Posted November 27, 2006 I have not read nothing about psycoactivity of seeds, but it would be a good way to hold alive the plant for a long, and dont begin from zero after you harvest the roots. Have you read something about psycoactivity of seeds?. Share this post Link to post Share on other sites
Auxin Posted November 27, 2006 I havent really read anything to suggest actual psychoactivity... just multiple sources that refer to the seeds as a hypnotic diuretic. Not precisely sure I want to try something that makes you pass out and pee simultaneously but if the diuretic effect is mild or if the dose was insufficient to induce sleep it could be interesting. Not sure if an infusion, decoction, or smoked extract would be the way to go. Share this post Link to post Share on other sites
apothecary Posted November 29, 2006 Hypnotic effect can be obtained from smoking the leaves. The mindset it puts me in, is indeed somehow reminiscent of tryptamines, and I honestly feel that the diuretic effect could be because of that? (if that makes sense) Share this post Link to post Share on other sites
Yeti101 Posted December 13, 2007 Seeds eh? I didn't even think of that as I'd heard (though I can't remember where) that the fruit causes nausea. This might be a stupid question, but has anyone tried smoking the root or root-bark? Share this post Link to post Share on other sites
Conan Troutman Posted December 13, 2007 dont know about amount of seeds, but 2-3 berrys is enough for gentle calming, taste like a chilli with no hear i reckn...although I also found it can make things a bit sexa never experienced the above described diuresis... Share this post Link to post Share on other sites
t st tantra Posted December 14, 2007 the berries are usually used for recovery from illness,for the elderly and to treat anaemia. i have one berry usually,the taste is a little bitter esp if the seeds are chewed,slight nootropic[relaxation with clear thinking] effects and maybe a little feel good effect. natural steroidal effects? the leaves were foul to smoke uncured. t s t . Share this post Link to post Share on other sites
Auxin Posted December 15, 2007 For the medicinal effects how many times a day do you use the berries? Can they be used in tandem with the root? Any idea if the dried berries would retain potency stored in the dark at 4° C for 11 months? I only get one harvest a year. Share this post Link to post Share on other sites
kadakuda Posted December 17, 2007 are they (seeds) safe to eat? Share this post Link to post Share on other sites
t st tantra Posted December 17, 2007 auxin,inreply to your q's,i basically dont know.........withania root is used in multi grams a day traditionally so i assume its safe...........i usually have a berry once a day but i think higher dosing would be fine.......and i expect potency would be retained for 12 months. t s t . Share this post Link to post Share on other sites
kadakuda Posted December 18, 2007 you probably checked this but here is what duke says: Chemicals 1,3,20-TRIHYDROXY-5,24-WITHADIENOLIDE Plant: DUKE1992A No activity reported. 14,20R,27-TRIHYDROXY-1-OXO-3,5,24-WITHATRIENOLIDE Plant: DUKE1992A No activity reported. 14-HYDROXYWITHANOLIDE-D Plant: DUKE1992A No activity reported. 17-HYDROXYWITHANOLIDE-D Plant: DUKE1992A No activity reported. 24-METHYLCHOLESTA-5,24-DIEN-3BETA-OL Plant: DUKE1992A No activity reported. 27-HYDROXYWITHANOLIDE-D Plant: DUKE1992A No activity reported. 3-TROPYLTIGLOATE Root: DUKE1992A No activity reported. 3ALPHA-TIGLOYOXYTROPANE Root: DUKE1992A No activity reported. 5,20ALPHA-®-DIHYROXY-6ALPHA,7ALPHA-EPOXY-1-OXO-(5ALPHA)-WITHA-2,24-DIENOLIDE Plant: DUKE1992A No activity reported. 5,24-STIGMASTADIEN-3-OL Plant: DUKE1992A No activity reported. 5,6-EPOXY-20-HYDROXY-1,4-DIOXO-2,24-WITHADIENOLIDE Plant: DUKE1992A No activity reported. 5,6-EPOXY-20-HYDROXY-1,4-DIOXO-2-WITHENOLIDE Plant: DUKE1992A No activity reported. 5,6-EPOXY-4,17-DIHYDROXY-1-OXO-2,24-WITHADIENOLIDE Plant: DUKE1992A No activity reported. 5,6-EPOXY-4,20-DIHYDROXY-1-OXO-2-WITHENOLIDE Plant: DUKE1992A No activity reported. 5,6-EPOXY-4,20-DIHYDROXY-1-OXO-24-WITHENOLIDE Plant: DUKE1992A No activity reported. 5ALPHA,17ALPHA-®-DIHYROXY-6ALPHA,7ALPHA-EPOXY-WITHA-2,24-DIENOLIDE Plant: DUKE1992A No activity reported. 6,7-EPOXY-5,27-DIHYDROXY-1-OXO-2,24-WITHADIENOLIDE Plant: DUKE1992A No activity reported. ALKALOIDS Leaf 900 ppm; DUKE1992A Root 1,300 - 4,300 ppm DUKE1992A No activity reported. ALPHA-WITHANANINE Plant: DUKE1992A No activity reported. ANAFERINE Root: DUKE1992A No activity reported. ANAHYGRINE Root: DUKE1992A No activity reported. BETA-SITOSTEROL Root 200 ppm; DUKE1992A Androgenic DUKE1992B ; Angiogenic X11988857 ; Anorexic MAR ; Antiadenomic M11 ; Antiandrogenic JE28:221 ; Antibacterial QJC28:155 ; Anticancer (Breast) PS131:95 ; Anticancer (Cervix) PJB1(2):287 ; Anticancer (Lung) PJB1(2):287 ; Antiedemic IC54=320 mg/kg orl DFN:160 ; Antiestrogenic JE28:221 ; Antifeedant 382 ; Antifertility JE28:221 ; Antigonadotrophic JE28:221 ; Antihyperlipoproteinaemic JBH ; Antiinflammatory; Antileukemic PJB1(2):287 ; Antilymphomic PJB1(2):287 ; Antimutagenic 250 ug/ml JAFC37:1365 ; Antiophidic 2.3 mg mus EMP5:363 ; Antioxidant IC44=10 uM JMF5:1 ; Antiprogestational JE28:221 ; Antiprostaglandin 30 mg/day/12 wks FT68(4):291 ; Antiprostatadenomic M11 ; Antiprostatitic 10-20 mg 3 x/day/orl man; Antipyretic HDN ; Antitumor (Breast) PS131:95 ; Antitumor (Cervix) PJB1(2):287 ; Antitumor (Lung) PJB1(2):287 ; Antiviral PS75:161 ; Artemicide LC50=110 ppm PC29(5):1667 ; Cancer-Preventive 525 ; Candidicide QJC28:155 ; Estrogenic PHM9:52 ; Febrifuge HDN ; Gonadotrophic JE28:221 ; Hepatoprotective PMP23:60 ; Hypocholesterolemic 2-6 g/man/day/orl M30 9-3,330 mg/man/day/orl MAR ; Hypoglycemic JE27:243 ; Hypolipidemic 2-6 g/day; Pesticide DUKE1992B ; Spermicide JE28:221 ; Ubiquiot JBH ; Ulcerogenic 500 mg/kg ipr rat FT63(1):3 CHAMASE Fruit: DUKE1992A No activity reported. CHLOROGENIC-ACID Leaf: DUKE1992A Aldose-Reductase-Inhibitor IC50=1.8 uM rat (strong activity) CPB47:340 ; Allelochemic SN149:389 ; Allergenic; Analgesic PMP23:51 ; Antiatherosclerotic X11413687 ; Antibacterial; Anticancer (Colon) PAL:335 ; Anticancer (Forestomach) PAL:335 ; Anticancer (Liver) PAL:335 ; Anticancer (Skin) PAL:335 ; Anticarcinogenic JAF45:1523 ; Antidiabetic X15796587 ; AntiEBV EMP6:189 ; Antifeedant; Antigenotoxic JAF45:1523 ; Antigonadotropic JNM1:10 ; Antihemolytic 10 uM PC36:579 ; Antihepatotoxic PM56(2):173 ; Antiherpetic EMP5:194 ; Antihistaminic DUKE1992B ; AntiHIV EMP6:189 ; Antihypercholesterolemic EMP6:189 ; Antihyperthyroid; Antiinflammatory PCF:19 ; AntiLegionella YAK122:487 ; Antileukotriene DUKE1992B ; Antimelanogenic JAF50:3718 ; Antimutagenic PCF:245 ; Antinitrosaminic; Antioxidant IC50=54.2 uM X15796587 IC53=200 ppm PCF:21 IC80=12 uM PC27:973 ; Antiperoxidant IC50=36 uM PM57:A54 ; Antipolio V&E ; Antiradicular 10 uM PC36:579 9 x quercetin JAF47:397 ; Antiseptic PMP23:51 ; Antisunburn PM61:510 ; Antithyroid JNM1:10 ; Antitumor JBH ; Antitumor (Colon) PAL:335 ; Antitumor (Forestomach) PAL:335 ; Antitumor (Liver) PAL:335 ; Antitumor (Skin); Antitumor-Promoter IC25=10 uM; Antiulcer EMP6:189 ; Antiviral V&D ; Autotoxic JCE26:315 ; Cancer-Preventive 525 ; Cardioprotective; Chemopreventive JAF53:3882 ; Cholagogue WIC ; Choleretic KCH ; Clastogenic JAF38:805 ; CNS-Active WIC ; CNS-Stimulant 1/6 Caffeine; Collagen-Sparing PM61:510 ; Diuretic; Fungicide NIG ; Hepatoprotective KCH ; Histamine-Inhibitor DUKE1992B ; Hypoglycemic X15796587 ; Immunostimulant; Insectifuge EB48:111 ; Interferonogenic EMP1:124 ; Juvabional 382 ; Larvistat JBH ; Leukotriene-Inhibitor DUKE1992B ; Lipoxygenase-Inhibitor IC23=5 mM JAF38:688 ; Metal-Chelator PCF:25 ; NO-Genic JAF50:850 ; Ornithine-Decarboxylase-Inhibitor PCF:19 ; Oviposition-Stimulant JBH ; Pesticide DUKE1992B ; Sunscreen PM61:510 ; Sweetener LAF ; Vulnerary CAN210 CHOLINE Root: DUKE1992A Antialzheimeran 5-16 g/man/day; Antichoreic DAS ; Anticirrhotic 6,000 mg/man/day DUKE1992B ; Anticystinuric DUKE1992B ; Antidementia PJB1(1):171 ; Antidiabetic DUKE1992B ; Antidyskinetic 150-200 mg/kg/man/day MAR ; Antihomocysteine SN160:282 ; Antimanic 15-30 g/man/day/orl PAM ; Antinociceptive X579998 ; Antisteatotic JN133:1302 ; Cardiodepressant SN160:282 ; Cerebrotonic SN160:282 ; Cholinergic CAN ; Hepatoprotective JN127:893S ; Hypotensive DUKE1992B ; Ileorelaxant FT1990:509 ; Lipotropic JE26:86 ; Memorigenic SN160:282 ; Parasympathomimetic (1/1,000th acetylcholine) HDN CUSCOHYGRINE Root: DUKE1992A No activity reported. CYSTEINE Fruit: DUKE1992A AntiAddisonian DUKE1992B ; Antibiotic JBH ; Anticataract PAM ; Anticytotoxic PM56(2):190 ; Antiophthalmic MAR ; Antioxidant 505 ; Antitumor DUKE1992B ; Antiulcer M29 ; Cancer-Preventive 525 ; Detoxicant M11 ; Glutathionergic AIL ; Ophthalmic-Antialkali JBH ; Pesticide DUKE1992B CYSTINE Fruit: DUKE1992A Adjuvant M11 ; Antihomocystinuric M29 DULCITOL Root: DUKE1992A Antitumor DUKE1992B ; Sweetener JBH HENTRIACONTANE Root: DUKE1992A No activity reported. HYDROXYPROLINE Fruit: DUKE1992A Vulnerary HG22:17 IPURANOL Root: DUKE1992A No activity reported. ISOPELLETIERINE Root: DUKE1992A Amblyopic WOI ; Emetic WOI ; Laxative WOI ; Mydriatic WOI ; Paralytic WOI NICOTINE Root: DUKE1992A Addictive PJN1(1):181 ; Analgesic 2 mg/kg ipr mus BBE ; Anorectic JE32:182 ; ANS-Paralytic 411 ; ANS-Stimulant 411 ; Antiestrogenic EMP6:189 ; Antifeedant DUKE1992B ; Antifumitory EMP6:189 ; Cardiovascular 0.25 mg/kg ivn dog BBE ; Cholinergic DUKE1992B ; Dopaminigenic QJC28(4):258 ; Ectoparasiticide M11 ; Epinephrininergic JE32:183 ; Herbicide IC57=5 mM 438 ; Hyperglycemic JE32:183 ; Insecticide IC100=1,000 ppm 438 ; Nematistat NIG ; Neurotoxic RJH ; Pesticide DUKE1992B ; Serotoninergic JE32:185 ; Tranquilizer PJB1(1):181 PSEUDOTROPINE Root: DUKE1992A No activity reported. PSEUDOWITHANINE Plant: DUKE1992A No activity reported. SCOPOLETIN Plant: DUKE1992A Aldose-Reductase-Inhibitor IC50=6.2 ug/ml cow CPB43:1385 ; Allelochemic IC89=2 mM 438 ; Analgesic PM56(6):595 ; Anesthetic HDN ; Antiadrenergic HDN ; Antiaflatoxin 11.4 ppm X11714299 IC50=65 uM X11714299 ; Antiarrhythmic; Antiasthmatic DUKE1992B ; Antibacterial JBH ; Antibronchoconstrictor; Anticholinergic; Antiedemic DUKE1992B ; Antifeedant 382 ; Antihepatotoxic BIS ; Antiinflammatory ED 1-10 ug/ear PM56(6):504 ; Antileukotrienogenic PM56(6):595 ; Antimutagenic MAB ; Antioxidant PH2 ; Antiprostaglandin RWG27 ; Antiseptic FT1990:503 ; Antispasmodic; Antitumor 2.9 ug/ml DUKE1992B ; Bronchorelaxant KCH ; Cancer-Preventive 525 ; Cholagogue WIC ; Choleretic KCH ; CNS-Depressant KCH ; CNS-Stimulant WBB ; Cytotoxic; Fungicide 2 mM BIOSIS'96 ; Hepatoprotective WIC ; Herbicide JBH ; Hypoglycemic EMP6:165 ; Hypotensive; MAO-Inhibitor X11575966 ; Musculotropic WIC ; Myorelaxant; Pesticide DUKE1992B ; Phytoalexin PC29(6):1789 ; Phytohormonal JBH ; Uterosedative 411 SOMNIFERIANINE Plant: DUKE1992A No activity reported. SOMNIFERINE Root: DUKE1992A Hypnotic DUKE1992B ; Sedative DUKE1992B SOMNIFERININE Plant: DUKE1992A No activity reported. SOMNINE Plant: DUKE1992A No activity reported. SOMNISOL Plant: DUKE1992A No activity reported. SOMNITOL Plant: DUKE1992A No activity reported. STARCH Root: DUKE1992A Absorbent M29 ; Antidote (Iodine) JBH ; Antinesidioblastosic M29 ; Emollient M29 ; Poultice M29 SUCROSE Root 1,000 ppm; DUKE1992A Aggregant PAM ; Antihiccup 1 tsp M29 ; Antiophthalmic M29 ; Antioxidant M11 ; Atherogenic PAM ; Collyrium JBH ; Demulcent JBH ; Flatugenic PFH46:77 ; Hypercholesterolemic PAM ; Preservative M11 ; Sweetener 1 x sucrose M11 ; Triglycerigenic PAM ; Uricogenic PAM ; Vulnerary M29 TROPINE Root: DUKE1992A Toxic JBH VISAMINE Root: DUKE1992A Hypothermic WOI ; Nicotinolytic WOI ; Sedative WOI WITHAFERIN-A Leaf 1,800 - 8,600 ppm DUKE1992A Antiadenocarcinomic 10-15 mg/kg WOI ; Antiarthritic WOI ; Antibacterial 10ug/ml WOI ; Anticarcinomic 10-15 mg/kg WOI ; Antiedemic 12-25 mg/kg ipr rat WOI ; Antiinflammatory WOI ; Antileukemic PE38:1 ; Antimitotic WOI ; Antiseptic JBH ; Antitumor WOI ; Antiviral WOI ; Cytotoxic ED50=0.28-40 JNP39:426 ; Fungicide 10 ug/ml WOI ; Immunosuppressant IWU ; Pesticide DUKE1992B WITHAFERINE Leaf: DUKE1992A No activity reported. WITHAFERINS Leaf: DUKE1992A No activity reported. WITHANANINE Root: DUKE1992A No activity reported. WITHANIC-ACID Plant: DUKE1992A No activity reported. WITHANINE Root: DUKE1992A No activity reported. WITHANIOL Root 800 ppm; DUKE1992A No activity reported. WITHANOLIDE-D Leaf 3,000 ppm; DUKE1992A Antiinflammatory ZUL ; Antiseptic JBH ; Antitumor JBH ; Immunosuppressant LRN-JUL88 ; Pesticide DUKE1992B WITHANOLIDE-G Leaf: DUKE1992A No activity reported. WITHANOLIDE-N Leaf: DUKE1992A No activity reported. WITHANOLIDE-O Leaf: DUKE1992A No activity reported. WITHASOMINE Root: DUKE1992A No activity reported. Share this post Link to post Share on other sites
