A human test of high purity Honokiol (approx 80 - 90% Honokiol content) consumed via capsule ---- personally conducted by the creator of this site --- suggests that for a person of average weight (160 lbs), a dose of 3-4 grams is well-tolerated. At a dose as high as 8 grams, the side effect is limited to nausea ... which is frequently the case with cancer drugs.
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The administrator of this site (160 lbs), who does not have cancer, has already established that 3-4 grams of high purity Honokiol (80-90%) taken orally once weekly is non-toxic, and that 8 grams caused nausea at worst.
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It would seem logical, based on the lab test-results with mice, that if a solution of Honokiol were to be injected directly into cancer-infected tissue in a human being via a long needle, it might kill large areas of cancer cells locally. This approach would be similar to that taken with direct injection into tissue of rabies victims, though with a cancer patient several different areas may require this approach at the same time. Whether this would ultimately slow metastasis is unknown, at it has never been tried.
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2004 also saw the release of a study from the Institute of Medical Sciences at Tzi Chi University demonstrating that Honokiol acted as an anti-seizure agent in lab animal tests, by acting as a "selective blocker of the NMDA receptor" in the brain.
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