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michaelangelica

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About michaelangelica

  • Rank
    Psychonaut
  • Birthday September 15

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  • Gender
    Male
  • Country
    Coastal NSW central coast
  • Interests
    I am interested in all useful plants.

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  • Climate or location
    Coastal n nsw
  1. michaelangelica

    Salvia help

    Not all sages are the same "Investigation of in vitro Opioid Receptor Binding Activities of Some Turkish Salvia Species" http://www.acgpubs.o...NP-1008-306.pdf The most active species, S. sclarea and S. dichroantha need further investigation for the identification of the active components responsible for this activity. I often nibble ornamental sages; many are intensely bitter, indicating a high level of alkaloid(s) . I just need a portable GC. is there an app for that yet?
  2. michaelangelica

    Psychotria ioniceroides

    Psychotria loniceroides https://www.facebook...115889528423447 Psychotripine, a trimeric pyrroloindoline derivative with an unprecedented hendecacyclic system bearing a hexahydro-1,3,5-triazine unit, was isolated from the leaves of Psychotriapilifera.
  3. michaelangelica

    Harvesting Leonitis leonurus/Wild Dagga/Lion's tail

    It is possible that the flowers and especially resin of the plant is the most active very easy to grow PS It is Leonotis leonurus Antinociceptive, antiinflammatory and antidiabetic effects of Leonotis leonurus(L.) R. BR. [Lamiaceae] leaf aqueous extract in mice and rats. Ojewole J.A.O. Methods and Findings in Experimental and Clinical Pharmacology. 27 (4) (pp 257-264), 2005. AB The present study was undertaken to investigate the antinociceptive, antiinflammatory, and antidiabetic properties of the aqueous leaf extract of Leonotis leonurus (L.) R. BR. (Lamiaceae) in mice and rats, to scientifically appraise some of the plant's ethnomedical uses, and its safety and efficacy. The leaf powder of the plant was Soxhlet extracted with distilled water and used. The antinociceptive effect of the plant's extract was evaluated by the "hot-plate" and "acetic acid" test models of pain in mice, while the antiinflammatory and antidiabetic effects of the leaf extract were investigated in rats, using fresh egg albumin-induced paw edema, and streptozotocin (STZ)-induced diabetes mellitus, respectively. Morphine (MPN, 10 mg/kg i.p.), diclofenac (DIC, 100 mg/kg i.p.), and chlorpropamide (250 mg/kg p.o.) were used, respectively, as reference analgesic, antiinflammatory, and hypoglycemic agents for comparison. L. leonurus leaf aqueous extract (LLE, 50-800 mg/kg i.p.) produced dose-dependent and significant (p < 0.05-0.001) antinociceptive effects against thermally and chemically induced nociceptive pain stimuli in mice. LLE (50-800 mg/kg i.p.) also significantly (p < 0.05-0.001) inhibited fresh egg albumin-induced paw edema, and caused significant (p < 0.05-0.001) hypoglycemic effects in rats. It is suggested that the analgesic effects of LLE (50-800 mg/kg i.p.) may be peripherally and centrally mediated. The different flavonoids, diterpenoids, polyphenolics, and other chemical constituents of the plant may be involved in the observed antinociceptive, antiinflammatory, and antidiabetic effects of the plant's extract. However, the results of this experimental animal study suggest that the aqueous leaf extract of L. leonurus possesses antinociceptive, antiinflammatory, and hypoglycemic properties, and thus lend pharmacological credence to the suggested folkloric uses of the herb in the management and/or control of painful, arthritic, and other inflammatory conditions, as well as for adult-onset, type-2 diabetes mellitus in some communities of South Africa. 2005 Prous Science. All rights reserved.
  4. michaelangelica

    Sceletium tortuosum - questions

    Isolation of Sceletium alkaloids by high-speed countercurrent chromatography ftp://111.68.111.206/e-Journal/Phytochemistry%20Letters/Vol.%204/No.%202/sdarticle_33.pdf
  5. michaelangelica

    Perfect Datura Administration

    Brugmansias are not Datura. A pity both are confused in this thread
  6. michaelangelica

    Tripterygium wilfordii - Thundergod Vine

    Determination of four pyridine alkaloids from Tripterygium wilfordii Hook. f. in human plasma by high-performance liquid chromatography coupled with mass spectrometry. J Chromatogr B Analyt Technol Biomed Life Sci. 2011 Nov 15;879(30):3516-22 Authors: Cai MQ, Chen XH, He SW, OuYang XK, Jin MC Abstract A novel liquid chromatography-atmospheric-pressure chemical ionization-mass spectrometry (LC-APCI/MS) method was developed and validated for the simultaneous determination of four sesquiterpene pyridine alkaloids (wilfortrine, wilfordine, wilforgine and wilforine) in human plasma. The chromatographic separation was performed on a Shim-pack XR-ODS column using an ammonium acetate buffer solution-acetonitrile in a gradient program. The detection was achieved by an ion trap mass spectrometry in the positive selected ion monitoring (SIM) mode. The method utilized acetonitrile as protein precipitation solvent and followed by solid-phase extraction (SPE). Calibration curves were linear for the four alkaloids over the range of 0.5-100.0 μg/L with the limits of quantification of 0.5 μg/L, while the method exhibited the recovery of 86.5-98.6%, intra- and inter-day RSDs of less than 8.2% and 12.8%, respectively. Methodology was validated in line with the EU requirements (Commission Decision 2002/657/EC). Results of incurred samples demonstrated excellent reproducibility. To our knowledge, this is the first analytical method for simultaneous determination of the four sesquiterpene pyridine alkaloids in plasma. The method was applicable to clinical pharmaceutical research of alkaloids in rheumatoid arthritis volunteer patients after oral administrations. PMID: 21982911 [PubMed - indexed for MEDLINE] Triptolide (TPL) inhibits global transcription by inducing proteasome-dependent degradation of RNA polymerase II (Pol II). PLoS One. 2011;6(9):e23993 Authors: Wang Y, Lu JJ, He L, Yu Q Abstract Triptolide (TPL), a key biologically active component of the Chinese medicinal herbTripterygium wilfordii Hook. f., has potent anti-inflammation and anti-cancer activities. Its anti-proliferative and pro-apoptotic effects have been reported to be related to the inhibition of Nuclear Factor κB (NF-κ and Nuclear Factor of Activated T-cells (NFAT) mediated transcription and suppression of HSP70 expression. The direct targets and precise mechanisms that are responsible for the gene expression inhibition, however, remain unknown. Here, we report that TPL inhibits global gene transcription by inducing proteasome-dependent degradation of the largest subunit of RNA polymerase II (Rpb1) in cancer cells. In the presence of proteosome inhibitor MG132, TPL treatment causes hyperphosphorylation of Rpb1 by activation of upstream protein kinases such as Positive Transcription Elongation Factor b (P-TEFb) in a time and dose dependent manner. Also, we observe that short time incubation of TPL with cancer cells induces DNA damage. In conclusion, we propose a new mechanism of how TPL works in killing cancer. TPL inhibits global transcription in cancer cells by induction of phosphorylation and subsequent proteasome-dependent degradation of Rpb1 resulting in global gene transcription, which may explain the high potency of TPL in killing cancer. PMID: 21931633 [PubMed - indexed for MEDLINE]
  7. michaelangelica

    Tripterygium wilfordii - Thundergod Vine

    High-throughput screening of chemical libraries for modulators of gene promoter activity of HLA-B2705: environmental pathogenesis and therapeutics of ankylosing spondylitis. J Rheumatol. 2011 Jun;38(6):1061-5 Authors: Zhao L, Liu CH, Yu D Abstract OBJECTIVE: Ankylosing spondylitis (AS) is a highly heritable disease with HLA-B27 being the strongest susceptible gene. In order to survey the environmental triggers for arthritis development, we used a high-throughput technique to screen the effects of 12,264 chemicals on the HLA-B27 gene promoter. METHODS: Promoter reporter transfectants 293T-HLA-B27 and HeLa-HLA-B27 were tested using robotics with 12,264 chemicals. Chemicals that modulated HLA-B27 promoter activity > 150% or < 40% were selected for further evaluation of IC50/EC50 and cell viability. RESULTS: The primary screening using the 293T-HLA-B27 promoter reporter cell line yielded 5.1% hits that either suppressed (556 chemicals) or enhanced (68 chemicals) the HLA-B27 promoter activity. A secondary reconfirmation screening was carried out with these 624 candidates using HeLa-HLA-B27 promoter reporter cells under several different culture conditions. The yield of positive candidates was 130, of which 47 were derived from natural products. Based on the bio-information of those positive natural products, 21 chemicals were selected for analysis by dose-response IC50/EC50 experiments. Eight compounds showed potential pharmacological activities. Two suppressors are both derived from an herbal medicine (lei gong teng) that has been used for decades to treat immune diseases. The 6 activators all belonged to a group of chemicals known as flavonoids, widely distributed among dietary fruits and vegetables. CONCLUSION: Several common dietary products that contain certain flavonoids might be environmental risk factors for AS; the Chinese traditional herb lei gong teng might be a potential drug for patients who are HLA-B27-positive. These results provide new research directions for the pathogenesis and therapeutics of AS. PMID: 21459940 [PubMed - indexed for MEDLINE]
  8. michaelangelica

    Smoking Ornamental Lobelia's

    Lobaline was used as nicotine replacement therapy. Ethnobotanically American Indians used it as well as tobacco and other herbs in their ceremonial peace pipes. All alkaloids seem to wear two faces, cure or kill. I have grow a few lobelias; The medicinal one to my memory was a large plant(1M+)with pretty scarlet red flowers You might still see it in Flower Catalogues (Chiltens?) Occasionally you might see it in nurseries. It needs a lot of water
  9. michaelangelica

    Tripterygium wilfordii - Thundergod Vine

    Torsten Have you seen this recent review? REVIEW A Chinese herb Tripterygium wilfordii Hook F in the treatment of rheumatoid arthritis: mechanism, eYcacy, and safety Jun Bao · Sheng-Ming DaiRheumatol Int (2011) 31:1123–1129 DOI 10.1007/s00296-011-1841-y 123
  10. michaelangelica

    indigenous opioid bark

    Barringtonia Patent Novel Analgesic Compounds, Extracts Containing Same and Methods of Preparation United States Patent Application 20070270375 Kind Code: A1 Various compounds obtained from plants of the Barringtonia species which are derived from Barringtoside A and Barringtoside C as precursor compounds which especially have an arabinopyranosyl substituent at the 21 position which may optionally be further substituted with benzoyl, dibenzoyl, methyl butanoyl, methyl butyryl or tigloyl at the 3 or 4 positions. Alternatively at the 21 position there is provided tigloyl, benzoyl or dibenzoyl substituents. http://www.freepatentsonline.com/y2007/0270375.html BTW A new pain relieving compound has recently been discovered in non-hot(as well as hot)Capsicum(s) spp.
  11. michaelangelica

    Native Ephedra Book

    Cytisus scoparius won't grow from cuttings. It should be a weed in SA; here it does not cope with my humidity. It needs European bees to polinate it. used medicinally (animals broken bones? JBL) It has anti-stress and moderate anxiolytic activity which may be due to its antioxidant effect
  12. michaelangelica

    indigenous opioid bark

    I have just added to Wiki's Barringtonia acutangula entry. In the 20 or so reseach papers I could find there was no reference to the plant containing opioids. Does anyone have a reference (apart from the ABC's beat up) to the opioid content of the plant please? Perhaps someone with more organic chemistry could look at the list of chemiclas I made. http://en.wikipedia.org/wiki/Barringtonia_acutangula#Medicinal_Uses
  13. michaelangelica

    The Portugese experiment Vrs the USA experiment

    LOL The problem with the big three intolerant religions is that they have so many good people working in, and for, them. This gives the evil people, in these fascist organizations, the cover to do harm and do evil things in the name of "god".
  14. michaelangelica

    Coffee 'does not make the brain more alert'

    I am a bit dubious about this research(?). I saw it in Cosmos online. I didn't really understand it so went to find the original article and it does not seem to exist.(!) or at least i could not find it given the author name and journal referenced.
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