What leads you to think the cambium layer is the highest concentration? I'll run a few small changes experiments to see if it adds up, might take a while though. It's an interesting discussion for sure, but I'm not sure what difference it makes in the end though. If, for a length of vine, the majority of alkaloids are in the cambium, you would still need to cut the same length of vine to achieve the desired result. It would certainly be easier to process the whole cross section that it would be to remove only a part of the cross section.
My experience with thicker vine leads me to believe it is stronger per weight than the same weight of thinner material. And thicker vine would have a higher proportion of core than thinner vine by weight, so my assumption is that the core holds the bulk. Maybe it's like cactus though. The green layer of outer flesh has the highest % but overall, often more total alkaloids are yielded by the white flesh due to its total weight.
It's been a while since we have done any experiments like this here, back to what SAB used to be about; knowledge!