Acacia King Posted October 7, 2014 I was bumbling around Sigma Aldrich's website this morning after reading a thread on here about p-coumaric acid. While I was having a look around I came across this: http://www.sigmaaldrich.com/technical-documents/articles/biology/interactive-metabolic-pathways-map.html?cm_sp=Insite-_-Academic-_-MetabolomicPathways It maps the entire human metabolic process. Thought a lot of you would dig it. Peace 4 Share this post Link to post Share on other sites
obtuse Posted October 8, 2014 damn yeah. i had to post it on facebook when i found it. meant to post it here too as its fascinating, but yesterday got a bit crazy. Share this post Link to post Share on other sites
obtuse Posted October 8, 2014 excuse my derpy moment. it was actually Roche where i found the map i was looking at. http://biochemical-pathways.com/#/map/1 http://biochemical-pathways.com/#/map/2 3 Share this post Link to post Share on other sites
FancyPants Posted October 16, 2014 I don't think I understand 95% of it but goddamn that gets me hot. Share this post Link to post Share on other sites
poisonshroom Posted October 16, 2014 I have a huge printed version of this on my wall - I got it printed for one of my biochem subjects, but I often still look at it and find interesting bits i missed. Pretty amazing how complex basic metabolism is (not to mention the all the other pathways that arent on here) Share this post Link to post Share on other sites
DELETED ACCOUNT Posted October 16, 2014 http://www.sigmaaldrich.com/technical-documents/articles/biology/interactive-metabolic-pathways-map.html?cm_sp=Insite-_-Academic-_-MetabolomicPathways http://biochemical-pathways.com/#/map/1 http://biochemical-pathways.com/#/map/2 These like, blow my mind, man. They're crazy complex. Awesome find! Share this post Link to post Share on other sites
FancyPants Posted June 1, 2022 I have a question for anyone who understands this more than I do (which is sadly still very little lol). I’m curious at what point and WHY is the hydroxyl group on the 4 position for psilocin 4-HO-DMT, compared to why it’s on the 5 position for Bufotenine 5-HO-DMT? Also, are there hydroxyls Off 1/4/6? I’m guessing they can’t be off 2/3 position due to the Nitrogen and Carbon atoms respectively? Is it because a hydrogen atom is shunted off more easily? In as minimalistic way I can get my query across lol. I see that according to the map and notes it mentions phosphorylation which IIRC relates also to the Difference between psilocybin and psilocin? But what in the great crippled fuck does that even mean? the reason I’ve been curious is the massive difference in effects between for example 5ho, 5meo, and nn; or baecystein(sp?) and aeruginacin to psilocin. I don’t even have my copy of TIKHAL atm but I probably wouldn’t understand anyway. Share this post Link to post Share on other sites
Alchemica Posted June 4, 2022 (edited) On 01/06/2022 at 11:00 PM, FancyPants said: I’m curious at what point and WHY is the hydroxyl group on the 4 position for psilocin 4-HO-DMT, compared to why it’s on the 5 position for Bufotenine 5-HO-DMT? New Discoveries in Magic Mushroom Enzymes - Psychedelic Science Review (psychedelicreview.com) Fungi seem to have different enzymes that hydroxylate the indoleamines at the 4 position (tryptamine-4-monooxygenase), whereas other metabolic pathways lead to 5-OH (eg enzymes like tryptophan-5-hydroxylase) Quote are there hydroxyls Off 1/4/6? I’m guessing they can’t be off 2/3 position due to the Nitrogen and Carbon atoms respectively? If you consider the numbering on the indole nucleus that might help you get an idea of the way it's numbered Quote massive difference in effects between for example 5ho, 5meo, and nn; or baecystein(sp?) and aeruginacin to psilocin. Consider changing the hydroxyl position from 4-OH to 5-OH changes a major part of the molecular structure that allows different binding characteristics to different receptors Take for example serotonin (5-OH-tryptamine) binds something like this to 5-HT2ARs Psilocybin binds more like this Consider how it changes the location of the hydroxyl group to allow different strength intermolecular forces with receptor proteins causing different binding profiles An important determinant of the neurobehavioral responses induced by a drug is its relative receptor selectivity. These different molecular structures allow different receptor binding profiles eg Psilocin: 4.00 5ht2b, 3.40 5ht1d, 3.37 D1, 3.03 5ht1e, 2.88 5ht1a, 2.83 5ht5a, 2.82 5ht7, 2.82 5ht6, 2.67 D3, 2.52 5ht2c, 2.19 5ht1b, 2.14 5ht2a, 1.77 Imidazoline1, 1.74 SERT, 1.57 Alpha2B, 1.36 Alpha2A, 1.03 Alpha2C where higher numbers mean higher binding. A 5-OH vs a 4-OH will change the profile of receptor binding Edited June 4, 2022 by Alchemica 2 Share this post Link to post Share on other sites
FancyPants Posted June 5, 2022 Alchemica you are an absolute LEGEND. thank you so much for taking the time to explain all that!! It hadn’t occurred to me that the positions were inclusive of the entire indole lol. I had assumed all this time it was just in reference to the left side (the benzene?) not sure why tho. very fascinating about fungi having different enzymes compared to animals and plants in that part of the process! i had a rudimentary understanding of how a molecule binds to a receptor, and how a seeming,y minor difference can have big practical differences (for example how one isomer can be far more potent than the other), but I hadn’t really clicked about the difference in the receptor subtypes either… ah man I feel satisfied with that answer like you wouldn’t believe lol. thank you again :D 1 Share this post Link to post Share on other sites