at0m Posted December 4, 2012 "It takes a long time for things to change in science," he says. "It's like pulling on the steering wheel of an ocean liner, then waiting for the huge ship to slowly turn."Salamone has spent most of his career battling a particular long-held scientific idea: the popular notion that high levels of brain dopamine are related to experiences of pleasure. As increasing numbers of studies show, he says, the famous neurotransmitter is not responsible for pleasure, but has to do with motivation. He summarizes and comments on the evidence for this shift in thinking in a Nov. 8 review in the Cell Press journal Neuron. In the early 1980's, explains Salamone, the National Institute on Drug Abuse put out a call for research on the neurological basis for drug abuse and addiction. The research that ensued built support for the idea that when the brain produced elevated amounts of dopamine, it was accompanied by perceptions of pleasure. The chemical quickly became known for this relationship, which was thought to be important for responding to drugs and other motivational substances, such as food. The chemical, which was formerly only thought to play a small role in movement, became over the subsequent decades among the most well-known and important in the brain. It turned out to be so important that it found its way into popular culture, with dozens of self-help books and websites explaining its relationship to feelings of happiness and reward. But over time, Salamone's studies and those of others started revealing problems. In animals, dopamine levels can spike after stress, such as losing a fight with another animal. Soldiers dealing with post-traumatic stress disorder also show activity in dopamine-rich parts of the brain when hearing recorded gunshots and other combat sounds. So if dopamine was really the pleasure element, then why all this association with negative experiences? Salamone's research over the past 15 years has attempted to find an answer to that question. His work involves artificially raising or lowering dopamine levels in animals, then giving them a choice between two rewards with different value, which can be obtained through different amounts of work. For example, what will a rat do when on one end of a corridor there's a pile of food, but on the other end there's a pile of food twice as big with a small fence to jump over on the way? As Salamone's studies have showed, animals with lowered levels of dopamine almost always choose the easy, low-value reward, while animals with normal levels don't mind exerting the effort to jump the fence for the high-value reward. Other studies in humans have corroborated these results, such as research with depressed patients. "Often, depressed people say they don't want to go out with their friends," says Salamone. But it's not that they don't experience pleasure, he says – if their friends were around, many depressed people could have fun. "Low levels of dopamine make people and other animals less likely to work for things, so it has more to do with motivation and cost/benefit analyses than pleasure itself," he explains. In essence, says Salamone, this is how amphetamines work, which increase dopamine levels and help people motivate to focus on tasks at hand. "When you give people amphetamines, you see them putting more effort into things," he says. The big implications of this change in understanding come at the level of overlapping motivational symptoms of depression with those seen in other disorders such as schizophrenia, multiple sclerosis, and Parkinson's disease. Symptoms of fatigue may be related to low levels of dopamine or changes in other parts of the same brain circuitry. On the one hand, this lack of perceived energy is maladaptive, because it reduces the tendency to interact with the environment. But, Salamone says, it could also reflect the body's attempt to save energy in a crisis. He points out that new ideas in science are traditionally met with criticism. But after all the mounting evidence, he says he's no longer regarded as "a crazy rebel," but simply someone who thought differently. "Science is not a collection of facts. It's a process," he says. "First we thought dopamine was involved only in movement. Then that faded and we thought it was pleasure. Now we've gone beyond that data on pleasure." Although he has thought about writing a popular-press book, he's not sure he really wants to go to the public and "debunk" the dopamine hypothesis of pleasure and reward. But if he ever does, one thing is for sure. "I can sum up all this work with one phrase, which would make a great book title," he says. "Dopamine: it's not about pleasure anymore." Original: http://today.uconn.edu/blog/2012/11/uconn-researcher-dopamine-not-about-pleasure-anymore/ Mirror: http://medicalxpress.com/news/2012-12-dopamine-pleasure-anymore.html Full paper: http://www.cell.com/neuron/abstract/S0896-6273%2812%2900941-5 The full paper is behind a paywall though I think some Uni's have access 5 Share this post Link to post Share on other sites
lhb2444 Posted December 4, 2012 Heres the full pdf if you want it. 1-s2.0-S0896627312009415-main.pdf 1-s2.0-S0896627312009415-main.pdf 1-s2.0-S0896627312009415-main.pdf 2 Share this post Link to post Share on other sites
Pat Uri Posted December 5, 2012 You bet! Folks are too simplistic about dopamine - it is vastly more complex than 1 + 1 = 2. Dopamine, up and down, here or there, has a cascade of responses through the amygdala, hippocampus, brainstem, hypothalamus, striatum, medial frontal lobes, including through the autonomic nervous system. It is only a sensitising neurotransmitter along with norepinephrine, serotonin etc. it is quickly replaced by adreno-corticosteroids, enkephalins, etc. themselves replaced with more permanent hard wiring. The brain has an amazing ability to become "normal" after a while - all manor of drug abuses may cause profound changes initially, but soon are actually required just to be normal. We all know folk who take a month's worth of drugs just to get out of bed and feel normal - not high. Rising dopamine levels release enkephalins - much like only rising levels of nicotine produce pleasure. Once you plateau, that's it...and just you wait for equal and opposite reaction in the 'come down'. "High" dopamine is associated with mania, dissociation, out-of-body experience, post traumatic stress and complete psychotic breakdowns - the extreme suggestibility of being frozen on the spot. The police use this stress effect to get information out of people - when they know they shouldn't be saying anything. Remember your right to silence and insist on it. Name, address and date of birth - other than that it's "Dunno!" or the best answer to everything "Forse che si forse che no". Keep easy on the l-dopa - you should know there are better ways to go! Respect! Share this post Link to post Share on other sites
Slybacon Posted December 5, 2012 I find things that block Neurotransmitters on the dopamine receptors give me amazing amounts of motivation, I get pleasure from this so they are connected. mmmm increased dopamine Share this post Link to post Share on other sites
CβL Posted December 5, 2012 <Scene is any conversation, that meanders long enough> Person 1: <something something> dopamine <something something>. Person 2: OH! Dopamine! I, know that one!! That's the pleasure chemical! Person 1: >_<* .......... -_- Share this post Link to post Share on other sites
