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Everything posted by Trip
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Syriab Rue/Ayahuasca & MAOI: Are the Dangers Real
Trip replied to Ishmael Fleishman's topic in Pharmacology, Chemistry & Medicine
Nexus might be worth checking out. -
Syriab Rue/Ayahuasca & MAOI: Are the Dangers Real
Trip replied to Ishmael Fleishman's topic in Pharmacology, Chemistry & Medicine
Both harmine and harmaline are reversible inhibitors of monoamine oxidase A (RIMAs). The mechanism of action is different to irreversible MAOIs like: Isocarboxazid, Phenelzine or Tranylcypromine. The bonds for reversible inhibitors are more easily broken as they are bonded through non-covalent mechanisms. Irreversible MAIOs permanently inhibited and altering the receptor site they target. Which is why pharmaceutical MAOIs have more dangerous interactions, whereas many who have extensive use with harmala will tell you the fears are offstated. Ofcourse mixing harmala with stimulants, certain pharmaceuticals, amphetamines etc isn't a good idea and there are ofcourse other factors such as half lives etc, but generally interactions with harmala are overstated. Now THH found in caapi is a bit different. It is thought to be a SRI with minimal reversible MAO-A activity. But i believe this is still controversial. -
Syriab Rue/Ayahuasca & MAOI: Are the Dangers Real
Trip replied to Ishmael Fleishman's topic in Pharmacology, Chemistry & Medicine
You should read up on the difference between pharmaceutical MAOIs and harmala which is a RIMA. The dangers are not the same. Having said that harmala will still have potential dangers when mixing stimulants/ amphetamine etc. -
Chasing Pyschotria Nexus if anyone has a spare plant/ cutting. Pm me. Thanks.
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Hi withdrawal clinic, I am aware of the site and yes it does appear that way. I am not after the back-cross-breeds, hence chasing nexus but its been out of stock for a long time.
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Bridgesii
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The IDLH ( immediately dangerous to life or health) for Xylene is 900 ppm. The IDLH for toluene is 500 ppm, and 1100 n-hexane naphtha isn't much better. So yeah i agree inhaling solvents is bad. However xylene and toulene are aromatic hydrocarbon consisting of a methyl group and a benzene ring, basically they are metabolized from a benzyl alcohol to benzoic acid in the body and then hippuric acid for urine excretion. n-Hexane is eventually metabolised in 2,5-hexanedione, which is neurotoxic causing polyneuropathy. Of course large amounts of just about any solvent in the system will cause health issues from organ damage to CNS issues etc but theses are different compounds that are metabolized differently and therefore have different/ more severe health effects than one another. Which is why n-hexane should be treated with extra caution, especially it's vapours as it is metabolized directly into a neurotoxin. I think from a safety POV the amount of n-hexane in shellite and the potential neurotoxic effects should be more widespread and known.
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Be-careful shellite is now (and maybe always has been) 30% n-hexane. Beware of the vapours, n-hexane is quite neurotoxic, ensure you have good ventilation (a mask would be a good idea too) and ensure you get a totally clean evap. Not to be confused with hexane.
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Hi all, Just reaching out and chasing Anadenanthera Colubrina cebil seeds (preferable cebil over yopo). Feel free to PM me so we can work something out.
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Very Interested, sent PM.
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Hi, chasing Acacia Courtii, if anyone is able to help or point me in the right direction. Happy to buy or trade.
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Chasing catha edulis if anyone can help, appreciate it.
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Still chasing catha edulis if anyone can help? Cheers.
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Mcgrath111 thanks for the reply, green preferably, but happy with either.
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Appreciate the offer and reply have sent a PM.