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Great friend of mine has inoperable stage 4 colon cancer that has spread to the liver, kidney and lungs ( she didn't even smoke cigarettes). I am looking for advice or ideas to help lessen the anxiety one has when facing a grim diagnosis. I have read great things about psilocybin being used to treat the anxiety of those living with terminal cancer. Does anyone have experience with this and or other psychedelics drugs being used in serious illness. She is on Rick Simpson oil already. Just looking for any ideas Thanks in Advance John
I am no puritan, and have drunk a shitload in my life. People often think I am anti-alcohol because of my website, but I'm not. I believe any adult should be able to use any drug they like. Do what you want as long as nobody else gets hurt. I am a teacher and therefore I think people need to be educated about alcohol, particularly in Australia, because my observations and experience has shown that we have no fucking idea what it does to you, in terms of harm, and we have been seduced into not even caring that we don't. Dr Alex Wodak is no puritan either. In fact he's got to be one of the most sensible, pro harm-reduction docs out there. Here's what he reckons about grog: What we now know is that alcohol consumption can never be justified on health grounds. Our understanding of its harms is all too clear — it is not a question of 'if' but a question of 'how much'. "The relationship between how much alcohol and how much harm differs for different kinds of harm," Dr Wodak said. "In some cases it seems to be linear, that is 'x' amount of drinking equals 'y' amount of harm, '2x' amount of drinking equals '2y' amount of harm." But in other cases, particularly heart disease, the risk associated with alcohol increases exponentially, so doubling your alcohol intake does a far greater amount of damage to the heart. Similarly for the liver — which the French are credited with abusing by steady, regular alcohol intake — alcohol-induced cirrhosis, or scarring of the liver, cannot be undone and eventually leads to liver failure. Long-term heavy alcohol consumption is also linked to an increased risk of cancer of the mouth, bowel, liver, prostate and breast. The brain also suffers from heavy regular alcohol consumption, although it can be difficult to separate the harm caused by alcohol from the harm caused by other behaviours and lifestyle factors that often go hand-in-hand with regular excessive drinking. http://www.abc.net.au/news/health/2015-12-01/is-binge-drinking-worse-for-your-health-than-drinking-every-day/6986912?section=health Heading into the festive season maybe stop and have a think about what's so festive about hangovers and liver failure aye? It's not a question of if it will happen, but when you've killed of heaps of brain cells you ostensibly will find it difficult to ask any questions any more. Just because loads of people will want YOU to drink because they are doesn't mean you have to, and just because there is a celebration going on doesn't mean you need to get shit-faced because you're an Aussie and it's "What we do!". Going 'slow' doesn't matter to your organs either, they're still getting smashed.. Enjoy your christmas, and any bevvies, but if you read this, try and remember. You know now, so use your education wisely. Love, your Nanny, RC.
Morris Crowley posted a topic in Pharmacology, Chemistry & MedicineGardner, D., F. Riet-Correa, D. Lemos, K. Welch, J. Pfister, and K. Panter. 2014. Teratogenic effects of Mimosa tenuiflora in a rat model and possible role of N-methyl- and N,N-dimethyltryptamine. Journal of Agricultural and Food Chemistry, Article ASAP. doi:10.1021/jf5005176. http://www.ncbi.nlm.nih.gov/pubmed/24689494 The researchers fed pregnant rats with food pellets containing some M. tenuiflora leaf, seed, alkaloid extract of the leaf or seed, or purified DMT or NMT, then examined them for abnormalities at 21 days gestation. The dosage was not extreme: the greatest concentrations were in the leaf enhanced feed, which contained around 150 μg/g apiece of DMT and NMT, while the feeds enhanced with either pure DMT or NMT contained around 60 μg/g. Cleft palates were observed to varying degrees in all groups except for the control. Skeletal abnormalities were observed in all groups, including the control, but occurred with significantly greater frequency in the experimental feed groups. For the DMT-fed rats, skeletal deformities were observed in approximately 48% of pups, while cleft palate issues were observed in approximately 6%. For the NMT-fed rats, skeletal deformities were observed in approximately 36% of pups, while cleft palate issues were observed in approximately 19%. The group fed a mixture of DMT and NMT (at 116 and 93 μg/g feed, respectively) showed the smallest incidence of skeletal malformations of the experimental feed groups, with approximately 13%; for comparison, the incidence in the control group was approximately 9%. The combined DMT and NMT also resulted in the highest incidence of cleft palate issues, approximately 57%, and was the only feed type where any pups exhibited hard palate damage. There is one very curious feature about this study: the rats were not fed any monoamine oxidase inhibitors (MAOIs) during the course of the study. Under ordinary circumstances, orally-administered DMT is rapidly metabolized by monoamine oxidase (MAO) enzymes before it can enter the bloodstream. Since no MAOIs were administered and the doses do not appear sufficient to saturate the MAO enzyme, it is most likely that any effects occurred not as a direct result of DMT or NMT, but as a result of their metabolites. The primary metabolite of both DMT and NMT is indole-3-acetic acid, and has been noted as `` mutagenic for mammalian somatic cells''. It is also unclear why teratogenic effects would only have been noticed in rats and Brazilian cattle. They are far from the only animals that eat tryptamine-rich forage. Both sheep and cattle sometimes graze on Phalaris grass, and while they occasionally suffer phalaris staggers, no correlation between Phalaris and birth defects has been noted. And giraffes eat large quantities of tryptamine-rich Acacia foliage, apparently without issue. What this means for humans is unclear. While the study didn't use outlandish quantities of DMT, the dosage schedule was still very different than in a DMT-using human. For the rats, DMT was consumed throughout the day as part of every meal. In humans, DMT is not typically used on a daily basis, much less on a perpetual basis. It is difficult to draw any equivalencies between sporadic use in humans and chronic low-level use in rats. Still, it raises some concerns for any women who consume DMT while pregnant.
Jonstn posted a topic in Chill SpacePizza ftw