Jump to content
The Corroboree


  • Content count

  • Joined

  • Last visited

  • Days Won


Everything posted by Alchemica

  1. I made lavender + chocolate once... the taste was intense! (questionably tolerable, I wouldn't want to make an oral spray with it!) 80gm raw cacao butter, 1 tablespoon virgin coconut oil, 3 tablespoons raw agave nectar, 800mg Lavandula angustifolia EO, 55 g Criollo (organic) cacao powder, 4g L-theanine, 2g L-tryptophan. The last three mixed well together until homogenous prior to addition. Melt the cacao butter, coconut oil over a pot of boiling water, stirring all the time, add agave and stir in to combine, add lavender oil and then add cacao powder + L-theanine + L-tryptophan stirring till lovely and smooth and shiny. Allow to set 20 x serves. each providing 200mg L-theanine. 40mg L. angustifolia EO* and 100mg L-tryptophan. 1-2 should calm a stressed body *80mg is as efficacious as paroxetine and lorazepam for generalised anxiety in some studies. I'd probably just try lavender first and skip the calamus and add some other calming stuff but up to you! I'd just try saffron gummies, the alcohol will evaporate off which is good and I'd guess it could survive 100deg C for a bit. Play around with the mint geranium. I like glycerites as I avoid alcohol, maybe you could mash up some leaves in some glycerine and pour off?
  2. You're correct on anions being negatively charged ions, while cations are positively charged ions. Air Purifiers: Ionic and Ionizers, Are They Bad for You? - Molekule Blog It seems ozone might have some detrimental effects on plant growth see: CO2 Science Do Air Purifiers Help Plants Grow? Can They Be Bad For Plants? (ionizerhub.com)
  3. Alchemica

    Options For Potent Anti-Anxiety Botanical

    Not sure if Adelaide is what you're after location wise. I haven't personally noted it dying down except if it got sunburnt then it stunts. I tend to get plants like this: I keep the leaf as it seems useful (but tastes horrible) - I make a glycerite to cover the taste a bit The leaves possess higher content of active withanolides, Withaferin-A and Withanone, as compared to the roots [1]. Nootropic and CNS therapeutic properties of the leaf have been claimed [2]. Withaferin-A is a potent leptin sensitiser with additional antidiabetic actions and resulted in a 20-25% reduction of body weight in overweight mice [3]. It improves insulin sensitivity [4]. Anti-neuroinflammatory properties have been ascribed to the leaf [5] along with neuroprotective properties [6] Withaferin-A shows anti-neuroinflammatory [7] anti-Aβ properties [8] and dopamine-restoring [9] properties. Improvement of cognitive dysfunction has been ascribed to Withanone [10] including inhibition of AChE, anti-Aβ, protection against oxidative stress and anti-inflammatory effects. Many toxicological studies have demonstrated that Ashwagandha, in its reasonable dose, is a non-toxic, safe and edible herb - despite that, there is sometimes movement away from the cytotoxic constituents towards root extracts which may be less effective [1] https://www.ncbi.nlm.nih.gov/pubmed/27936030 [2] https://www.ncbi.nlm.nih.gov/pubmed/26361721 [3] https://www.ncbi.nlm.nih.gov/pubmed/27479085 [4] https://www.ncbi.nlm.nih.gov/pubmed/30417321 [5] https://www.ncbi.nlm.nih.gov/pubmed/27550017 [6] https://www.ncbi.nlm.nih.gov/pubmed/25789768 [7] https://www.ncbi.nlm.nih.gov/pubmed/26266054 [8] https://www.ncbi.nlm.nih.gov/pubmed/30356847 [9] https://www.ncbi.nlm.nih.gov/pubmed/30544122 [10] https://www.ncbi.nlm.nih.gov/pubmed/29108796
  4. Alchemica

    Options For Potent Anti-Anxiety Botanical

    Either they had it in a sealed vessel under pressure, or were using a different solvent. I'd personally suggest, if you want to explore, just downing a few high α-acid hop pellets and seeing if it's your thing. I used about 3g dried pellets, not sure the best dose to use but you want to skull them down to avoid tasting them at all personally I was just giving you my notes, I was interested in the iso-α-acids for a bit for their different CNS profile but they are SO BITTER at the required doses you'd have to be really masochistic. The brew was horridly hard to drink! Maybe if you isomerised them, dried it out and capped it up it would be ok
  5. Alchemica

    Options For Potent Anti-Anxiety Botanical

    The main actives are normally considered to be withanolides which are steroidal lactones ie more fat soluble so it's likely to primarily be the ethanol that extracts them. For a very crude extraction: Drying and powdering the root first helps. I'd do alcohol first as that's likely to be the best solvent and maybe the only one needed? Sit the dry, powdered root (weigh it first) in sufficient warm ethanol and leave to extract. As for how much, depends how much you have to spare! Pour off the ethanol filtering through something - I use a hop brew straining bag to filter it, if you fold it over itself a few times you get a good filter for bulk herbs -saving the filtrate and repeat again, extracting the root material, if possible with a second lot of alcohol. Wash the material in the filter with some alcohol too. Carefully evaporate it and dry to resin/powder. You could repeat using boiling water to extract (boil it in water, filter, evaporate to leave resin, dehydrate to powder) Filter bag: That said, it seems the best solvent is 50:50 alcohol:water as a single extraction solvent: "The maximum extract yield and the total withanolide and phenolic content were obtained from aqueous alcoholic compositions at 50:50 (v/v), 70:30 (v/v), and 100:0 (v/v), respectively" so maybe a single extraction with 50% ethanol is better than doing two separate extractions! On Ashwagandha, if you're not averse to alcohol, you could also try an ashwagandharishtha-style preparation [1]. It's a really pleasant way to take the medicine, if you don't mind the interesting flavour. "Emerging evidence suggests the ability of fermentation to enhance the bioactivity and therapeutic potential of traditional medicines. Indeed, the fermentation was shown to increase the availability of the active molecules and to eliminate the undesired compounds." Ashwagandharishtha is a liquid polyherbal formulation traditionally prepared by fermentation process using the flowers of Woodfordia fruticosa. It contains roots of Withania somnifera as a major crude drug. Alcohol generated during the fermentation causes the extraction of water insoluble phytoconstituents. Yeasts present on the flowers are responsible for this fermentation. I simply fermented ashwagandha root etc with added yeast and sugar. [1] https://doi.org/10.1016/j.imr.2013.04.002 [2] https://www.ayurmedinfo.com/2011/06/27/ashwagandharishta-uses-ingredients-dose-and-side-effects/
  6. Alchemica

    Options For Potent Anti-Anxiety Botanical

    Just a simple extraction using both alcohol and boiling water as two different solvents (ie doing the extraction once with alcohol, then following up repeating with water). Most of the constituents in things like Passiflora and Skullcap seem to be flavonoids so it seems to suit such. Only do it if you like the effect of the particular herb - try it in unextracted form as a higher dose first - just makes dosing more convenient. Hops I used to just eat the hop brewing pellets, either as is or boil them for awhile to isomerise it Here are some of my notes, sorry for the over-detail. Hops increases GABA levels. The typical use for hops is for sleep disturbances and mood disorders, such as anxiety and restlessness. Data from in vivo studies in rats have shown that a hops extract and its fraction containing alpha-bitter acids (humulones) exert significant sedative and antidepressant effects, whilst hops beta-acids (lupulones) appear to also exhibit antidepressant activity with fewer sedative effects, probably by affecting gamma-aminobutyric acid (GABA) neurotransmission activity. Moreover, in vitro binding experiments have shown that hops interact with certain serotonin (5-HT6) and melatonin (ML1) receptor subtypes, which are involved in various CNS functions related to stress activity, relaxation, circadian rhythms and sleep. Zanoli et al. have investigated the in vivo and in vitro effect of hop beta-acids on central nervous system function and suggested an antidepressant-like activity. Behavioral effects of beta-acids fraction were explained by a modification in the GABAergic activity. That said it contains a highly potent phytoestrogen 8-prenylnaringenin)]. Terpenes likely add to the effect eg myrcenol, which is produced from myrcene during boiling hops Iso-α-acids Iso-α-acids prevented hippocampal inflammation and cognitive impairment and seem particularly effective for the suppression of inflammation-induced depression-like behaviour and appear to do this in part via activation of the vagus nerve, which can in turn improve depression-like behaviour, as a safe and novel approach for treating depression Generally the bitterness induced by effective doses of iso-α-acids precludes their acceptance but they have been shown to a) safely reduce body fat b) improve cognition in metabolically induced cognitive impairment and c) improve working memory I used Galaxy 15.7% α-acids "The rate of conversion of α-acids to iso-α-acids was highly dependent on temperature. For typical 100°C boiling conditions, 77% of alpha acids were isomerized within 120 min. Temperatures of 130 °C isomerized 100% of alpha acids within 30 min of heating. A 90 min boil at 100 °C corresponded to a final iso-alpha acid concentration equal to 60% of the starting alpha acid concentration" The α-acids fraction can be considered as the major responsible constituent for the enhanced GABAergic action and for the antidepressant property The bitter iso-α-acids: - improve health by influencing lipid metabolism, glucose tolerance, and body weight - could be effective for improvement of working memory potentially through enhancement of dopamine release - consumption prevents inflammation in the hippocampus and ameliorates age-related cognitive decline - can suppress hippocampal inflammation and improve hyper neural activity - suppress neuronal damage and depression-like behaviour induced by inflammation Hop β-bitter acids (lupulones) also show antidepressant-like effects. Lupulones are activators of TRPC6, which mediates antidepressant activity The fraction containing β-acids needed a dosage approximately 6 times higher than that of α-acids for sedative effects
  7. Alchemica

    Options For Potent Anti-Anxiety Botanical

    Agreed, there's wild variability. For herbs, I settled on doing very simple alcohol/water extracts on raw herbs as it provided a more reliable effect outcome. Even simple water/alcohol dual extracts reduced to a resin then oven dried/dehydrator at lowish temps often leave generally effective extracts, often found they reduced to around 7X extracts after filtering all solids out and evaporating. It's easy to get imported extracts that are super questionably even what they say they are As far as kava, for the better one I've found at chemists (it's not great but find it better than others) is 'Bioglan' capsules that contain an extract powder that is better than nothing and can add to herbal synergies when better stuff isn't available. Another one I've explored in the past but forgot to mention is Californian Poppy root. "...rather than disorientating the user, it tends to normalise psychological function" Both aerial parts and roots contain alkaloids, the latter being MUCH richer (1.6-2.7%) Traditionally used for several disorders “Reactive, agitated and masked depressions, melancholy, neurasthenia, neuropathy, organ neurosis, vegetative-dystonic disturbances, imbalances, constitutional lability of the nervous system”, as well as a sleep-inducer and sedative tea. Relative safety is evidenced by traditional use of the plant, which can be found in the European market for more than 30 years without any safety concern. Affinity for the benzodiazepine receptors and alkaloids increase the binding of GABA to GABA receptors Binding to 5-HT1A and 5-HT7 receptors
  8. Alchemica

    Options For Potent Anti-Anxiety Botanical

    I tried to rank some subjectively on potency once recently and came up with this list: Lemon balm < Lower dose Passiflora < Lower dose skullcap < Zizyphus seed < Hops = Valerian < Oral lavender oil 80-160mg = lower dose kava = low dose CBD < Erythrina mulungu < Higher dose 25g+ Passiflora < CBD 600mg + < Higher dose skullcap < High dose kava. Some I haven't found overly notable despite evidence base eg Galphimia glauca Things like saffron, lavender, passionflower etc appear to be worthy of consideration for the treatment of depression and anxiety with minimal risk of serious side effects. Even years after abstinence from alcohol etc, still find the Passionflower comparatively mild unless the dose is high. The skullcap seems more notably anxiolytic but I still require higher doses than normal. As my 'chill' blend I used 300mg kavalactones + Skullcap and Passiflora [both dual alcohol/water extract] In a study of herbalist preferences for anxiety reduction, the overall the herb of choice was S. lateriflora It had notable effects in reducing subjective anxiety scores [1] S. lateriflora may be superior to pharmaceutical anxiolytics in its ability to produce mood enhancing effects without side-effects such as a reduction in energy or cognition or causing fatigue [2] [1] https://pubmed.ncbi.nlm.nih.gov/12652886/ [2] https://pubmed.ncbi.nlm.nih.gov/23878109/ If it's OCD-like you might consider saffron: Saffron (Crocus sativus L.) has demonstrated antidepressant effects in clinical studies and extensive anxiolytic effects in experimental animal models. It reputedly has acute effects. Saffron is a potential efficacious and tolerable treatment for major depressive disorder with anxious distress. It increased mood, reduced anxiety and managed stress without side effects, offering a natural alternative to standard treatments and likewise has effects comparable to conventional pharmacotherapy for OCD. It has been used to augment and reduce side effects of SSRIs. .
  9. Alchemica


    Thought I'd share how Eremophila are currently being studied Biodiscoveries within the Australian plant genus Eremophila based on international and interdisciplinary collaboration: the results and perspectives on outstanding ethical dilemmas Personally, the most interesting finding was DAT modulating compounds from E. oppositifolia The latest (unpublished) results comprise the identification of compounds isolated from Eremophila species, capable of both potentiating and inhibiting the transport of dopamine The search for novel ligands from Eremophila species targeting neurotransmitter:sodium symporters Abstract: The family of neurotransmitter:sodium symporters (NSSs) mediate rapid re-uptake of neurotransmitters released to the synaptic cleft making them important determinants of neuronal communication. Accordingly, drugs that modulate their activity are central for the treatment of many neuropsychiatric diseases, such as depression, attention deficit hyperactivity disorder (ADHD), anxiety and narcolepsy. However, many patients do not respond adequately to the current drugs. Others stop the treatment due to severe side effects. In addition, high-affinity inhibitors for many NSS proteins are still to be found. Here, we present results from purified compounds and extracts from Eremorphila species for their activity towards the dopamine transporter (DAT). We find that the addition of the branched chain fatty acid KU030-14 potentiated DAT transport of dopamine. We also found several extracts that inhibited DAT activity. Taken together, we find it possible that Eremorphila species contain one or more active compounds towards DAT and possibly also other NSS proteins. https://synbio.ku.dk/calendar/2019/1st-cross-continent-eremophila-conference/speaker-information/
  10. Alchemica

    Interactive Metabolic Pathways Map

    New Discoveries in Magic Mushroom Enzymes - Psychedelic Science Review (psychedelicreview.com) Fungi seem to have different enzymes that hydroxylate the indoleamines at the 4 position (tryptamine-4-monooxygenase), whereas other metabolic pathways lead to 5-OH (eg enzymes like tryptophan-5-hydroxylase) If you consider the numbering on the indole nucleus that might help you get an idea of the way it's numbered Consider changing the hydroxyl position from 4-OH to 5-OH changes a major part of the molecular structure that allows different binding characteristics to different receptors Take for example serotonin (5-OH-tryptamine) binds something like this to 5-HT2ARs Psilocybin binds more like this Consider how it changes the location of the hydroxyl group to allow different strength intermolecular forces with receptor proteins causing different binding profiles An important determinant of the neurobehavioral responses induced by a drug is its relative receptor selectivity. These different molecular structures allow different receptor binding profiles eg Psilocin: 4.00 5ht2b, 3.40 5ht1d, 3.37 D1, 3.03 5ht1e, 2.88 5ht1a, 2.83 5ht5a, 2.82 5ht7, 2.82 5ht6, 2.67 D3, 2.52 5ht2c, 2.19 5ht1b, 2.14 5ht2a, 1.77 Imidazoline1, 1.74 SERT, 1.57 Alpha2B, 1.36 Alpha2A, 1.03 Alpha2C where higher numbers mean higher binding. A 5-OH vs a 4-OH will change the profile of receptor binding
  11. Can chuck some blue corn and Glass Gem Rayaa in an envelope no cost just PM me. Also Oaxacan Green Can't guarantee viability but chuck it in the ground and see I'll have more purple corn soon hopefully as a late crop is almost nearly done. Also have maybe 10 Glass Gem Rayaa corns I picked slightly too early, you're welcome to them if you can use them experimentally for your bourbon
  12. Alchemica

    Brahmi, gotu kola

    I can give you Centella asiatica [1] (what I was sold as C. asiatica) and what I think is Centella cordifolia (Swamp pennywort) [2] Let me know if they're suitable 1. 2.
  13. I'd suggest Sacred and herbal healing beers: the secrets of ancient fermentation as a starting point. I've PM'd the link If you wanted to get technical, I tried to brew with things early in the mix if I wanted to encourage potential bioconversion of actives, or add them later if the actives were likely to be degraded to less active metabolites. You could consider if the actives are likely to be destroyed, or bioconverted to more potent ones with a bit of research "...fermentation could be considered as a potential technology for releasing phenolic compounds from natural resources, as well as for producing new bioactive compounds. The ability of fermentation to improve the yield and to change the profile of phenolic compounds is mainly due to the release of bound phenolic compounds, as a consequence of the degradation of the cell wall structure by enzymes produced during fermentation." [1] The simple recipes simply use things like: Lemon BaIm AIe 4 pounds dark brown sugar 3 gallons water 1/2 pound dried lemon balm herb yeast Boil 3 gallons water with 8 ounces dried lemon balm herb and 4 pounds sugar for one hour; skim off scum. Let cool and strain into fermenter. Add yeast. Ferment until complete; 7 to 10 days. Prime bottles, fill with beer, and cap. Ready to drink in one to two weeks.
  14. Back to playing with essential oils... There's some new papers Exploring Pharmacological Mechanisms of Essential Oils on the Central Nervous System A Review of the Potential Use of Pinene and Linalool as Terpene-Based Medicines for Brain Health The main oil I've been diffusing is Eucalyptus because it's not only cheap but it seems to have some neat benefits on paper. Also fond of lavender still. 1,8-cineole can elevate synaptic 5-HT levels by increasing the releasable synaptic pools of 5-HT, exocytosis and levels in the synapse and is a novel therapy for treating depression [1] It has anti-inflammatory and antioxidant effects. It is proposed to be a NMDA antagonist and AChE inhibitor [2] with plasma 1,8-cineole concentrations correlated with cognitive performance [3] Increases in dopamine release with exposure to 1,8-cineole and eucalyptus oil were 241 ± 29% and 182 ± 16%, respectively [4]
  15. Alchemica


    There's initial human studies on some of the probiotic strains used in commercial kombucha's eg Bacillus coagulans GBI-30, 6086 Clinical studies showed that consuming BC30 helped alter the gut microbiome by increasing the numbers of beneficial bacteria, and ex vivo testing of blood from elderly humans who had consumed BC30 for 28 days showed increased anti-inflammatory cytokine responses. Results from a recent clinical trial suggest that the consumption of BC30 supports exercise performance and helps reduce exercise-induced muscle damage. Cell walls from the live B. coagulans GBI-30, 6086 strain have demonstrated immune modulating and anti-inflammatory effects in vitro. The immune-modulating effects of the BC30 strain were associated both with the cell wall fraction and with the metabolites produced by the live bacteria in vitro. It has shown benefit in IBS and rheumatoid arthritis
  16. Alchemica

    Ion-exchange resin capsules

    You fiend, sounds like something I would have done. Can't suggest it's good practice to bypass such a safety measure. Normally amine drugs are absorbed onto cationic ion exchange resins with sulfonic acid groups to form : "cation exchange resins contain acidic functional group capable of removing cations from basic solutions. The use of ion exchange resin to prolong the effect of drug release is based on the principle that positively or negatively charged pharmaceuticals, combined with appropriate resins yield insoluble polysaltresinates. Ion exchange resonates when administered orally, they are retained in stomach for two hours in contact with an acidic fluid of pH 1.2 and then move into the intestine at a slightly alkaline pH. Towards the large intestine, desorption from resins and absorption into the body may be slowed due to low fluid content and poor absorption in colon" Here is acidic release in the stomach: Ref I would have thought you could likely do a strong acid eg HCl wash of the resin to liberate the amine.HCl salt into solution but maybe strongly basic conditions to liberate the free amine is the way to go.
  17. Cocaine self-administration disrupted by the N-methyl-D-aspartate receptor antagonist ketamine: a randomized, crossover trial. Repeated drug consumption may progress to problematic use by triggering neuroplastic adaptations that attenuate sensitivity to natural rewards while increasing reactivity to craving and drug cues. Converging evidence suggests a single sub-anesthetic dose of the N-methyl-D-aspartate receptor antagonist ketamine may work to correct these neuroadaptations and restore motivation for non-drug rewards. Using an established laboratory model aimed at evaluating behavioral shifts in the salience of cocaine now vs money later, we found that ketamine, as compared to the control, significantly decreased cocaine self-administration by 67% relative to baseline at greater than 24 h post-infusion, the most robust reduction observed to date in human cocaine users and the first to involve mechanisms other than stimulant or dopamine agonist effects. These findings signal new directions in medication development for substance use disorders.
  18. Alchemica

    Free Purple Corn

    I had a hard time finding a viable seed for purple corn. Tried Morado Pitch Black etc and no luck. I eventually settled on Thai Hybrid F1 Purple Corn. Enjoyed growing those. If anyone wants me to put some free seeds in an envelope just let me know. Not sure what it will revert back to as it's a hybrid but hopefully something purple Once again, sorry, No WA/Tas
  19. Wondering if anyone has ever stumbled across literature on the phytochemistry, toxicology or any use of the Corydalis that seem to be widely available and widespread in Australia? The ones I mainly see are hybrids like C. flexuosa x elata I'm growing it simply as it's attractive with it's blue flowers and as a shade-loving plant but curious if it is otherwise useful? Despite not finding any analysis for flexulosa or elata (other than the anthocyanins in the flower) there is one mention "Those species which grow in China, including C. flexuosa, have been included in the Chinese herbal pharmacological choices for pain relief." [1] One thread here states the types commonly used in Chinese Medicine are: Corydalis yanhusuo, C. turtschaninovii, C. ambigua, C. repens. The most extensive alkaloid breakdown of Corydalis species I can find is unfortunately in a different language and doesn't seem to list any details for flexuosa etc Tetrahydropalmatine for example has been isolated from: C. cava C. decumbens C. intermediata C. ochroleuca C. saxicola C. sempervirens C. solida C. yanhusuo C. ambigua C. caseana C. tashiroi C. lutea C. pallida C. solida C. tashiroi It seems to list some therapeutic Corydalis as: Corydalis ambigua Cham. & Schlatdl Corydalis bulbosa Pers. Corydalis decumbens (Thumb.) Pers. Corydalis chaerophylla DC. Corydalis incisa Pers. Corydalis koidzumiana Ohwi Corydalis longipes DC. Corydalis meifolia Wall. Corydalis pseudoadunca Popov Corydalis ramos Wall. Corydalis saxicola Bunting Corydalis speciosa Maxim. Corydalis turtschaninovii Besser
  20. Has anyone added medicinal Amaryllidaceae to their garden? It's been briefly discussed here over the years here but has anyone found a practical Amaryllidaceae with favourable toxicological properties to grow? I've been interested in them for a bit as garden additions. The first one that got my interest was Boophone disticha whose crude ethanolic extracts and some alkaloidal phytoconstituents possess potent SERT/5-HT1A mediated [One article states triple reuptake inhibition of 5-HT/NE/DA] antidepressant and anxiolytic effects [1] That said, it seems to have some scary toxicity too (unless you like deliriums) and is not broadly available (and $$$) Then there's things like Narcissus pallidulus and Narcissus cv. Hawera. Having to deal with the toxicity of lycorine being present in cv. Hawera sounds unpleasant so Narcissus pallidulus sounds most interesting personally Narcissus cv. Hawera biosynthesizes Sceletium-type and Amaryllidaceae alkaloids [mesembrenone, galanthamine and lycorine as major alkaloids], while The Narcissus species from section Ganymedes (N. triandrus L., N. pallidulus Graells, Narcissus lusitanicus Dorda & Fern. Casas, and N.iohannis Fern. Casas) have been found to biosynthesize mainly mesembrenone (over 70% of all alkaloids). Narcissus pallidulus accumulates only Sceletium-type compounds [mesembrenone and 6-epi-mesembranol]. [2] Mesembrenone represented 64.1 % of the total alkaloid fraction extracted from leaf of Narcissus cv. "Hawera" [3] The highest galanthamine content was identified in Narcissus cv. Sundisc (69% of TIC) and Narcissus cv. Waterperry (67% of TIC)
  21. Alchemica

    Free Purple Corn

    Sorry @bob-bob just missed out, thanks to all who requested seeds. All sent and out of seed.
  22. Alchemica

    Free Lobelia cardinalis seed

    I've got quite a few of these going from seed, small seedlings now, but if anyone missed out (note: state restrictions still apply) and has a SERIOUS actual interest in the plant let me know and I'll try and gift you a small plant once they're a bit bigger, otherwise they get donated to the dark-side of aesthetic flower appreciating grandmas Traditional use: Root infusion for worms, rheumatism; leaf infusion for colds, fever; root poultice for sores Constituents [1]: Aerial parts: alkaloid lobinaline Hairy root culture: diacetylene triol lobetyol + glucosides lobetyolin and lobetyolinin Leaves: anthocyanin cyanidin-3-O-[6-O-(4-O-E-p-coumaroyl-O-α-rhamnopyranosyl)-βglucopyrano]-5-O-β-glucopyranoside See more: https://www.cargocultcafe.com/tag/plant-identification-lobelia-cardinalis/ Some initial bioassays [2]: Positive "when it comes to stimulation, cardinalis is more like nicotine. Seems to give stimulant effects similar to mild nicotine. Seems to have mild aphrodisiac properties. Slight mood lift present it also seems to have anti depressant properties. ...the anti-depressant effects cannot be compared to anything - because you just feel better, it's not anything like pharmaceutical anti-depressants. ...it's painkilling potential is huge. powerful muscle relaxant and really potent painkiller..." Less positive: "L. inflata is far more effective than L. cardinalis and L. siphilitica in my opinion." [1] http://dx.doi.org/10.3390/medicines5040121 [2] https://drugs-forum.com/threads/lobelia-cardinalis.213716/
  23. Alchemica

    Free Purple Corn

    Let them ripen on the plant. split them up then dehydrated at low temp. Worked for my other corns, hopefully these too. Hope you've been enjoying yours!
  24. Alchemica

    Free Lobelia cardinalis seed

    -just trying my best to be legit without even knowing what I have to technically be legit about... if it's not an issue I still have a few seed pods on their way and can plonk them to where permissible. From what I've heard TAS is pretty strict on even seed
  25. Alchemica

    Free Lobelia cardinalis seed

    Thanks for the interest, have three people!