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The Corroboree

Trip

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Posts posted by Trip


  1. Both harmine and harmaline are reversible inhibitors of monoamine oxidase A (RIMAs).

    The mechanism of action is different to irreversible MAOIs like: Isocarboxazid, Phenelzine or Tranylcypromine. The bonds for reversible inhibitors are more easily broken as they are bonded through  non-covalent mechanisms.  Irreversible MAIOs permanently inhibited and altering the receptor site they target. Which is why pharmaceutical MAOIs have more dangerous interactions, whereas many who have extensive use with harmala will tell you the fears are offstated. Ofcourse mixing harmala with stimulants, certain pharmaceuticals, amphetamines etc isn't a good idea and there are ofcourse other factors such as half lives etc, but generally interactions with harmala are overstated.

     

    Now THH found in caapi is a bit different. It is thought to be a SRI with minimal reversible MAO-A activity. But i believe this is still controversial.

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  2. Hi withdrawal clinic, I am aware of the site and yes it does appear that way.

     

    I am not after the back-cross-breeds, hence chasing nexus but its been out of stock for a long time.


  3. The IDLH ( immediately dangerous to life or health) for Xylene is 900 ppm.
    The  IDLH for toluene is 500 ppm, and
    1100 n-hexane
    naphtha isn't much better.
    So yeah i agree inhaling solvents is bad.
     

    However xylene and toulene are aromatic hydrocarbon consisting of a methyl group and a benzene ring, basically they are metabolized from a benzyl alcohol to benzoic acid in the body and then hippuric acid for urine excretion.

    n-Hexane is eventually metabolised in 2,5-hexanedione, which is neurotoxic causing polyneuropathy. Of course large amounts of just about any solvent in the system will cause health issues from organ damage to CNS issues etc but theses are different compounds that are metabolized differently and therefore have different/ more severe health effects than one another. Which is why n-hexane should be treated with extra caution, especially it's vapours as it is metabolized directly into a neurotoxin.

    I think from  a safety POV the amount of n-hexane in shellite and the potential neurotoxic effects should be more widespread and known.

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  4. Be-careful shellite is now (and maybe always has been) 30% n-hexane. Beware of the vapours, n-hexane is quite neurotoxic, ensure you have good ventilation (a mask would be a good idea too) and ensure you get a totally clean evap.  Not to be confused with hexane.

    • Like 1

  5. Hi all,
              Just reaching out and chasing Anadenanthera Colubrina cebil seeds (preferable cebil over yopo).

    Feel free to PM me so we can work something out.

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