Alchemica Posted November 3, 2023 (edited) Anyone by chance explored? Agapanthus campanulatus Quote Unspecified parts are used by the Sotho in South Africa to treat people “who have the spirit”, which appears to be a type of mental disturbance (Laydevant, 1932). The Zulu use unidentified species of Agapanthus for inducing visions (imibono) and dreams in South Africa (Nonkazimlo Podile, pers. comm.). Modified from [1] - rhizome of A. campanulatus used in the initiation of traditional healers due to the presence of active principles as yuccagenin and agapanthagenin but both of them cause gastrointestinal tract and kidney problems (Ndhlala et al., 2013; Bonokwane et al., 2022). Triterpenoid saponins are thought to be the main actives of ubulawu such as Agapanthus companulatus. No alkaloids were detected in Agapanthus campanulatus In vitro assays (ethanol extracts from the leaves) showed good binding affinity to serotonin, dopamine and noradrenaline transporters [2] It is possible that the triterpenoid saponins found in Agapanthus campanulatus and other ubulawu species and their interactions may be responsible for these antidepressant actions, as well as the other reported psychoactive effects [3,4] References Ahmed Mohamed Younis, Alshymaa AbdelRahman Gomaa, Alyaa Hatem Ibrahim, Mohamed S.A. Abdelkader, Samar Yehia Desoukey, The genus Agapanthus: A review of traditional uses, pharmacological and phytochemical attributes, South African Journal of Botany, Volume 150, 2022, Pages 1168-1183, ISSN 0254-6299, https://doi.org/10.1016/j.sajb.2022.09.029 Mikael E. Pedersen, Bernadeta Szewczyk, Katarzyna Stachowicz, Joanna Wieronska, Jacob Andersen, Gary I. Stafford, Johannes van Staden, Andrzej Pilc, Anna K. Jäger, Effects of South African traditional medicine in animal models for depression, Journal of Ethnopharmacology, Volume 119, Issue 3, 2008, Pages 542-548, ISSN 0378-8741, https://doi.org/10.1016/j.jep.2008.08.030 Jean-Francois Sobiecki, Psychoactive Ubulawu Spiritual Medicines and Healing Dynamics in the Initiation Process of Southern Bantu Diviners Journal of Psychoactive Drugs, 44 (3), 216–223, 2012 https://doi.org/10.1080/02791072.2012.703101 Bonokwane Melia Bokaeng, Lekhooa Makhotso, Struwig Madeleen, Aremu Adeyemi Oladapo Antidepressant Effects of South African Plants: An Appraisal of Ethnobotanical Surveys, Ethnopharmacological and Phytochemical Studies Frontiers in Pharmacology, 13, 2022 https://doi.org/10.3389/fphar.2022.895286 Edited November 4, 2023 by Alchemica Share this post Link to post Share on other sites
fyzygy Posted November 4, 2023 (edited) https://www.sciencedirect.com/science/article/abs/pii/S0254629922005075 In case DOI link is broken, reference 1. (It was for me). Noxious weed vs. bushfire retardant: https://www.gardenexpress.com.au/is-agapanthus-a-weed-species-in-australia/ A few varieties and traditional uses: https://aussiegreenthumb.com/agapanthus-how-to-grow-guide/ I've heard that agapanthus can be hard to dig up (Geraldine Hickey did a comedy sketch on the topic, a year or two ago). Edited November 4, 2023 by fyzygy 1 Share this post Link to post Share on other sites
