Ipomoea aquatica? Paeonia lactiflora?

[naja naja]

Can any1 give me sum more info on these plants?

cheers

N

[The Deb-One-Amine]

Ipomoea aquatica

Sci Alert:

www.scialert.net/fulltext/?doi=ijb.2008.123.129

Paeonia lactiflora:

FromMediherb

The root of Paeonia lactiflora and the stem of Sinomenium acutum are two herbs widely used in traditional Chinese

medicine (TCM) for the treatment of inflammatory and arthritic diseases (both herbs are on the ARTG register of listable

herbs). In treating arthritis, TCM practitioners usually include both herbs in their formulations which suggests that there

might be synergistic effects between them. Pharmacokinetic studies on the interaction of the purported active

constituents of these herbs (paeoniflorin and the alkaloid sinomenine) were undertaken. Following oral administration

to rats, the pharmacokinetic alterations were compared. The results showed that the pharmacokinetic parameters of

oral administration of paeoniflorin were markedly enhanced when co-administered with sinomenine. The bioavailability

as measured by the maximum plasma concentration for the mixture was between 5–10 times that of the paeoniflorin

alone. In addition, the half-life of the distribution phase was increased significantly and distribution to the main internal

organs was markedly increased. The increase in bioavailability could not be attributed to the alteration of the protein

binding ability (as indicated by the results of a series of in vitro tests), but may be related to inhibition of Pglycoprotein.

However, with respect to the in vivo influence of paeoniflorin on sinomenine, the results showed that coadministration

of paeoniflorin did not affect the pharmacokinetic parameters and tissue distribution of sinomenine.

 

Edited September 24, 2010 by The Deb-One-Amine

[kadakuda]

I. aquatica. It's what's for dinner.