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The Corroboree

Black Rainbow

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Posts posted by Black Rainbow

  2. Posted

    Ogunbodede, O., et al., New mescaline concentrations from 14 taxacultivars ofEchinopsisspp. Cactaceae San Pedro and their relevance to shamanic practice. J. Ethnopharmacol. 2010.pdf

    Ogunbodede, O., et al., New mescaline concentrations from 14 taxacultivars ofEchinopsisspp. Cactaceae San Pedro and their relevance to shamanic practice. J. Ethnopharmacol. 2010.pdf

    Ogunbodede, O., et al., New mescaline concentrations from 14 taxacultivars ofEchinopsisspp. Cactaceae San Pedro and their relevance to shamanic practice. J. Ethnopharmacol. 2010.pdf

  6. Posted

    Ok, so drug activity at the 5ht2b receptor has been linked to cardiovascular issues:
    https://www.ahajournals.org/doi/10.1161/01.CIR.102.23.2836

    https://www.nejm.org/doi/full/10.1056/NEJMp068265

     

    People with high blood pressure are often excluded from clinical studies with LSD due to the association with increased cardiovascular activity:

    https://onlinelibrary.wiley.com/doi/full/10.1111/j.1755-5949.2008.00059.x

     

    As I understand it, there is still some lesser affinity of psilocybin/psilocin for 5ht2b. I haven't been able to find any info on mescaline affinity 5ht2b. I'd be interested to compare the affinity of mescaline and psilocybin, as you might be able to infer that the substance with the least affinity would have the least cardiovascular risk.

  7. Posted

    I think the phase 3 clinical trials of MDMA assisted psychotherapy will be a critical piece of evidence in the current consideration of MDMA rescheduling  with the TGA. It is an exciting area and a pity there is not more evidence concerning this therapy for other conditions. If the new schedule is made I suspect access will be for PTSD sufferers alone.

     

    Microdosing psychedelics is a bit of a tricky concept. Pharmacologically, microdosing would imply there is no pharmacological effect. With psychedelic microdosing, there is a pharmacological effect but the psychoactive effects are subperceptual. I have read anecdotal reports of nausea with mescaline microdosing. Perhaps some people are less susceptible to this. I also think this nausea might reduce once a bit of a tolerance has built up. Very little research has been done in this area unfortunately.

  8. Posted

    What a fantastic episode. Some highlights - Nichols burns Strassman on endogenous DMT, suggests some concerns about the 5ht2b receptor and microdosing LSD, and talks about the background of the Heffter institute.

    https://drugscience.org.uk/podcast/27-pharmacology-of-drugs/

    If anyone has more information to share about 5ht2b and microdosing risks, please share them. I'm going to do some more research on this topic and will share anything I find here. LSD seems often to be the substance of choice for microdosing as many people find psilocybin tiring and mescaline nausea inducing, so I think it is important to find the harm reduction message here.

    • Like 1

  10. Posted · Edited by Wile E. Peyote

    I had to chop some funky bits from a pach clone I'm quite confident has a low mescaline content. I don't have access to froehde reagent but I do have mandelin, mecke, marquis, simon's and robadope, so I put some drops of each directly on the white flesh between the cactus skin and the core. There was no reaction for any reagent besides mecke, which went yellow and turned brown slowly (90 seconds + to turn completely brown).

     

    I would expect mescaline to react with mandelin and marquis, but there was no reaction with these reagents in this test. The mecke test was consistent with what I might expect from mescaline. Perhaps mecke is more sensitive? I will repeat this test with different plants in the near future.

  12. Posted

    Hey fyzygy,

    Sorry you've had trouble joining the group. There are no pending member requests so I can only guess that your application was denied because someone thought you might be a troll or fake FB account. Apply to join again and send me a DM with the name on your FB account, I'll make sure you are added.

  13. Posted

    Thanks WC, I can be a bit of a pessimist about people/plant relations so it is nice to hear you reflect on this so positively. I hope you are right, I would be very pleased if my plants desired to live and be cared for in my garden.

  14. Posted

    Grafted CSD often looks like a normal bridge, they get much more interesting on their own roots.

    Have you tried the Aus Trich Auctions FB group? You could do a search for previous sellers and contact them privately. I'm familiar with most people's reputation in that group so if you want a reference for a a buyer you find there, just ask :)

  15. Posted

    I still wonder if plants could speak for themselves what they would say about being removed from the wild.

    Does anyone know any interesting case studies of species being reintroduced? Bonus points for psychoactive species...

  16. Posted

    Specifically I'm interested in using froehde reagent to estimate mescaline concentration in cactus. I thought it would be interesting to dry material from something like PC and compare a spot test with something like Eileen. I'm hoping there will be some reaction and that an estimate of potency might be made based on the time taken for colour change.

    I also wonder if anyone has done something similar with ehrlich reagent and Acacia or another equivalent.

  17. Posted

    Hey Flux, 

    I think you're right, there is a good chance that people won't or can't catalogue their plants, but I still think it is worthwhile. The idea is to start a stand alone website for this catalogue which could then be promoted widely online and within the community.

    I'm not sure about tricks for flowering, I know of only a few growers that have had success so far. Maybe @Glaukus or @communacacian can chime in?

  19. Posted · Edited by Wile E. Peyote
    Included Glaukus' suggestion

    I'm in the process of setting up a website to keep track of ex-situ courtii. I'm hoping to get some feedback on the data the website will collect about these plants. The draft survey for collecting this data is as follows:
     

    Country:
    State:
    City:
    Plant quantity. From seeds: (0-10 000) From cuttings: (0-10 000)
    Where did you get the propagation material for these plants?
    ______________________________________________________________________________________________________________
    How old are these plants? (0-100)
    What are the growing conditions of these plants? (how much sun do they get, how do you fertilise them, what growing medium are they in, etc.)
    ______________________________________________________________________________________________________________
    How many of these plants have flowered? (0- 10 000)
    Are there Acacia growing nearby? (Y/N)
    If yes, can you tell us which Acacia species?
    ______________________________________________________________________________________________________________

    Are these plants experiencing any health issues? (i.e. galls, borers, symptoms with unknown causes etc.)
    ______________________________________________________________________________________________________________
    Have you registered these plants at courtii counter before? (Y/N)
    Is there anything else relevant to courtii conservation that you would like to share with us?

    ______________________________________________________________________________________________________________
     

    • Like 1

  22. Posted · Edited by Wile E. Peyote

    Cheers Micromegas, no I don’t think there is something you’re unaware of, my guess is that the toad campaign has some vegan vibes. Pretty small project without a lot of community involvement, I think. I’ve been able to find very little information about the campaign online.
     

    Conservation is such an overwhelming issue. The information required is so vast, and then you need to organise people, institutions and all their contradictory interests. Sheesh!

    • Like 1

  23. Posted · Edited by Wile E. Peyote

    I agree that wealthy people are the most likely to benefit and least likely to be negatively impacted by covid, but I don’t think government and other institutional responses are as strategic or organised as you suggest.

    Reduced individual freedoms seems like a fair price for increased collective safety, but I can understand that this might trigger memories of political trauma.

     

  24. Posted · Edited by Wile E. Peyote

    From what I was able to find, Myerhoff only seems to have two more Loph publications besides Peyote Hunt. La Barre has a few more. I found his paper Twenty Years of Peyote Research and used this to mine additional relevant papers also. I have now added all these papers to the list.

  25. Posted

    Earlier in this thread I mentioned the relationship between indigenous people and plant conservation. I've often pondered if indigenous people are entitled to maintain wild harvest practices that impact on vulnerable species. I mentioned a podcast with an interview with KT in a different thread the other day (https://www.indefenseofplants.com/podcast/tag/3?fbclid=IwAR1Flce33poULl8cCqeWD6tW6drdg2ALcNSmLuToJLc2j2jI6cX1iP1nCzM) and in this podcast KT gives a great anecdote in which he expresses his support for Amazonian people to maintain their B. caapi harvest traditions, discussing a preference for vine over leaves even though leaves can be more potent and potentially more sustainable to harvest than vine. KT claims two people maintaining traditions with these plants stated the leaves tasted wrong (or something to this effect) and went on to suggest that this might relate to different alkaloid profiles, and that this particular profile was central to the maintenance of tradition.

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