Alchemica
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Posts posted by Alchemica
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5 hours ago, saguaro said:
What is meant by interact with native double helical DNA in this instance? As far as I'm aware MTXs aren't mutagens, MTX actions should be accounted for by acute signalling mechanisms and effects on transcription.
They "... interact with all the base pairs of DNA (A-T; G-C) and phosphate group through hydrogen bond (H-bond) interaction." Probably similar to things like beta-carbolines that interact in the way below. Other ones like coralyne and berberine also form a complex with DNA, probably by intercalation, giving rise to therapeutic effects in things like cancer.
Johnson, I.M., Prakash, H., Prathiba, J., Raghunathan, R., Malathi, R. Spectral analysis of naturally occurring methylxanthines (theophylline, theobromine and caffeine) binding with DNA. PLoS One 2012, 7, e50019. https://doi.org/10.1371/journal.pone.0050019
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Anyone used theobromine for a sustained period and found it useful for attention deficits? The cacao flavonols would likely be synergistic over theobromine alone
It's only an animal model study so far but potentially an option
Theobromine improves hyperactivity, inattention, and working memory via modulation of dopaminergic neural function in the frontal cortex of spontaneously hypertensive rats
https://doi.org/10.1039/D4FO00683F
While it has a nonselective PDE inhibition effect greater than caffeine, oral theobromine inhibits mTOR signalling in vivo which is of relevance to multiple conditions [1] and elevates cerebral brain-derived neurotrophic factor and facilitates learning in animal models [2] and orally supplemented, it upregulates the pathways in the mPFC, which may then improve working memory in animal models [3].
MTXs act through a variety of different molecular mechanisms: mobilization of intracellular calcium, inhibition of phosphodiesterases (PDEs), modulation of gamma-amino butyric acid (GABAA) receptors, inhibition of high affinity ATP-dependent cyclic nucleotide transporters and antagonism of adenosine receptors. The plasma levels that could be reached under dietary regimes and the fact that MTXs readily cross the blood-brain barrier indicate that these drugs inhibit adenosine receptors in the CNS; higher doses may be required to mobilize intracellular calcium, inhibit PDEs or modulate GABAA receptors, or to unselectively inhibit ABCC5 and ABCC4 transporters. Moreover, despite the physiological relevance, also under scrutiny is how caffeine, theobromine and theophylline are able to interact with native double helical DNA
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On 02/05/2024 at 4:58 PM, fyzygy said:
What is an easy source of pinene terpenes?
Theres Aus shops like this Home - My Terpenes Australia
For pinenes, I tend to use frankincence essential oil unless you can get the pure terpene - ~30-60% α-pinene. There seems to be different enantiomers in different oils which needs to be taken into account. Even between B. carterii and B. sacra there seems to be different pinene enantiomers.
α-pinene: anti-inflammatory via PGE1, acetylcholinesterase inhibitor - aiding memory, positive modulator of GABAA receptors at BZD sites. α-pinene was observed to initiate soothing physiological and behavioural responses with a significant impact on physiological and psychological relaxation.
(1R)-(+)-α-pinene was more prevalent than (1S)-(−)-α-pinene in pine oils
(+)-α-Pinene was the predominant enantiomer in most rosemary, this is intriguing as (-)-α-pinene displays partial modulation of GABAA-BZD receptors and direct binding to the BZD binding site of GABAA receptor while the (+)- enantiomer is less characterised.
α-Pinene shows anti-metastatic and anti-tumor activities. Moreover, it seems to be anti-inflammatory, anti-oxidant and an anti-allergic bronchodilator and can produce anxiolytic and hypnotic effects via the GABAergic system (α-PN shows anxiolytic and hypnotic effects upon inhaled administration. α-PN evokes its hypnotic action through direct binding to GABAA as a partial modulator at the benzodiazepine binding site
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I've played around a bit with terpenes/Citrus oils, even making a transdermal spray. I find they get more interesting as synergistic blends.
Komiya and colleagues (2006) observed that lemon oil vapor inhalation causes an anti-stress effect by modulating serotonergic and dopaminergic in addition to GABAergic systems in mice. Limonene enhances neurotransmitter release and could inhibit HPA activity under physical stress, It may act via regulating dopamine levels and 5-HT receptor function, along with GABAA activity.
Citrus essential oils have been utilised widely in traditional medicine"Improvements in neuroendocrine, neurotrophic, and monoaminergic systems are related to the antidepressant effects of limonene". It produces antidepressant-like effects that seems to be mediated by 5-HT and dopamine neurotransmission and is an agonist for adenosine A(2A) receptors.Lemon essential oils showed strong ability to improve memory in animal modelsIt is suggested "metabolites of these monoterpene compounds contained in citrus essential oils have a stronger effect on monoamine release from brain tissue than the monoterpene compounds themselves"
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3 minutes ago, fyzygy said:
I've been propagating this for a while now, but have no experience with consumption. How does it taste? Grows well from cutting, but not from seed, in my (limited) experience.
No experience with consumption myself either but maybe I need to expel some bad spirits....-
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Doing lots of cuttings of this at the moment, if someone wants to grow it get in touch here. No WA/TAS.
QuoteThe traditional healers use Iresine herbstii with the ritual aim to expel bad spirits from the body. Furthermore, Iresine herbstii was used in association with other plants, such as Trichocereus pachanoi, for divination, to diagnose diseases, and to take possession of another identity.
Tea has been prepared from the leaves, rich in antioxidants.
Iresine herbstii (Amaranthaceae), traditionally called “cimora se˜ norita”, is used in black magic (De Feo, 2003) and in association with San Pedro for magic rituals (Friedberg, 1959; Dobkin De Rios, 1977; De Feo, 2003), to diagnose illness, and to take possession of another identity (Cruz-Sanchez, 1948). Its leaves are claimed, for external use, a skin depurative, whereas the aerial part decoction is known to be an antipyretic (De Feo, 2003).
- anti-inflammatory, cytotoxic and apoptotic activities and antioxidant activity
- affinity for the 5-HT1AR
- affinity for 5-HT2C receptor and for D1 receptor (MeOH extract)
- lower affinity for D1 and higher affinity for D2 receptors (Aq. extract)
- presumable antagonist action on D1 and D2 receptors by Iresine (both extracts)Leaves: 2,5-Dimethoxy-6,7-(methylenedioxy)-isoflavone; acylated betacyanins
Roots: oleanolic acid and its saponins. An alcoholic extract of the root showed the presence of amino acids, steroids, triterpenoids, alkaloids and coumarins.
https://doi.org/10.1016/j.jep.2005.11.022
https://doi.org/10.1076/phbi.34.3.184.13212
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On 29/03/2024 at 8:00 PM, Alchemist said:
Galantamine is the real deal for lucid dreams. It worked again last night.
Unfortunately the more easily available huperizine A is useless for me. Took up to 400 mcg and simply felt weird the next day.
DMAE , 50mg eq. freebase for a week did nothing for dreams either.
Calea has done nothing in the past, but I never took it after sleeping for 4 hours first , like needs to be done for galantamine. So I will be giving that a go in a few days, after the G has cleared from the system.
Galantamine is interesting as it functions as both an AChE inhibitor and positive allosteric modulator of a7-nAChRs, I found it quite cognitively interesting but wasn't looking for lucid dreams. On the contrary, huperzine A seems more to be AChE/NMDARs.
Your DMAE dose seems personally quite low but I can see there being challenges using it with sleep as some people find it activating. As the bitartrate 250mg-500mg may be more typical, eq, dimethylaminoethanol freebase ~186mg at the upper dose.
Out of interest, have you explored something like CDP-choline as a cholinergic? It seems to have procognitive effects mediated by predominately a7-nAChR activation. More recently there's been interest in coupling AChE inhibition with CDP-choline or alpha-GPC for dementias and that seems to be an effective augmentation, so perhaps that could be possible to cautiously augment huperzine A with such, in theory.
I have some Silene undulata 98% triterpenoid saponins extract from the SAB store, if you want a bit in an envelope no cost send me a PM. It didn't get as frothy as expected (presumptive test for saponins) but did form a lasting sort of foam to some extent.
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There's been a bit of research into fermentation of different plants with either lactic acid bacteria or yeasts. I've tried to summarise a bit of it here
The Science of Fermented Fruits, Veggies and Plant Medicines - Pharmacology, Chemistry & Medicine - The Corroboree (shaman-australis.com)The bacteria and yeasts are in a way potentially mildly psychoactive, hence their often-termed action as "psychobiotics". I've only tried milk kefir, which is interesting in it's own way, as the kefir peptides are too mildly psychoactive but you're right, fermenting a plant into the mix is an interesting concept and worth exploring more.
There's the classic example of Sceletium which I've tried to explore here with yeasts
yeasts to encourage bioconversion.pdf
QuoteAlongside the nutritional and psychobiotic effect, a diversity of peptides from casein are released by kefir including at least 5 opioid peptides. Opioid effects have been also reported following oral administration of casein hydrolysates. The peptides may exhibit anxiolytic-like and cognition enhancing activities. Kefir peptides may also act as anti-oxidants, immunomodulators and anti-obesity agents
Let us know if you do any experimenting
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Stuck with this for awhile and there's been the slow but gradual return of some seemingly simple cognitive functions when used catalytically with effort and attempting to retrain my mind.
For example, I was unable to sit and watch something as simple as a short youtube clip and follow the video. I've lately got back into watching inspirational short videos that I'm enjoying and can now watch something like a 30min clip which was previously totally unfeasible. I've started to embrace the need to do a lot more simple cognitive remediation in my day, for example getting back into colouring in an adult colouring books etc as an activityIt hasn't all been linear for recovering some levels of very basic functionality, the cognitive fatigue associated with essentially retraining and forging some new connections of some basic cognitive functions has been extreme and literally left me floored and sometimes come at the expense of maintaining functionality in other domains.
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There seems to be several factors that limit berberine's bioavailability to the <1% mark:
- poor absorption
- extensive metabolism
- efflux back to the intestinal lumen by the action of permeability glycoprotein (P-glycoprotein, P-gp)
As piperine from black pepper works on the cytochrome metabolism and P-gp level, it may very well be worth considering but haven't seen it done
Things that have been studied are detailed here
the phospholipid-berberine complexes including things like encapsulating it in lecithin seem to have some significant effects on bioavailability in studies but wasn't able to personally tell how effective it was, lets just say I had lots of experiments happening.
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12 hours ago, Ishmael Fleishman said:
Has anyone used Berberine and to what effect?
Thanks for the writeup.
I explored a long time ago, also made up a mix of berberine hydrochloride with lecithin trying to improve it's bioavailability and was interested in it's CNS effects and beneficial metabolic effects, the CNS effects particularly related to it's sigma-1 agonism, prolyl oligopeptidase activity and monoaminergic effects
Berberine may offer benefit in the control of psychotic and depressive symptoms, along with metabolic side effects. It has a broad range of CNS relevant pharmacological actions, including sigma-1 agonism, acetylcholinesterase inhibition and a range of neuroprotective effects including neurotrophin-mediated neuroprotection (NGF). There are some limitations to its use, including bioavailability and difficulties in reaching active levels in the CNS. “The potential use in schizophrenia was suggested when berberine was found to act as a D2-receptor antagonist, although it was also noted that dopamine level was increased in the brain as partly responsible for its antidepressant mechanism. It is unclear if these influences on dopamine level and action may counter each other, diminishing the proposed antipsychotic effect. Future studies may also elucidate whether berberine will exacerbate extrapyramidal motor symptoms due to the blockade of D2 receptors. On the other hand, it was proposed that the anxiolytic effect of berberine resulted from its antagonism at 5-HT2 receptor. This finding may indicate less severe motor side effects, if there are any, when berberine is used as an antipsychotic since atypical antipsychotics also act via 5-HT2 receptor blockade. A possible advantage of berberine over other antipsychotics is its ability to inhibit prolyl oligopeptidases, the activity of which is elevated in psychosis and not targeted by antipsychotics at present.”
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1 hour ago, fyzygy said:
Sounds promising. I hope the positive effects increase over time.Which Acorus species (and plant parts) have you been concentrating your efforts on?
I'm just using a likely high asarone Acorus calamus essential oil. I don't want to make it a long-term addition but something to get out of a rut. Early days but small subjectively useful shifts, combined with little lifestyle shifts when I can seem to help slightly. I get very rigid in my routines and behaviours, so if this is a way to potentially plasticise my mind and behavioural repertoire a bit that could be good
QuoteWould sub-lingual also work while avoiding toxic effects?
That could be useful and possibly minimise toxicity? I know some people simply chew the calamus rhizome, that seems to be the suggested way to use the Japanese Sweet Flag SAB sells for stimulant effects. This intranasal spray is a bit more full on with quite significant levels of asarone which I think would be hard to reach via plain herb
QuoteVariegated sweet flag, I think you mentioned that it had been traditionally used among Japanese to treat stuttering?
Yeah that one's Acorus gramineus, it's got a diverse range of constituents that have interesting pharmacology aside from asarones. Still, whilst it seems to have quite prominent TCM use etc, I'd probably stick with chewing it etc as you mention
My notes on A. gramineus
QuoteAcorus gramineus is a traditional medicine used to treat various disorders including cognitive disorders where of all the traditional Chinese medicines used in treating cognitive disorders, the rhizome appears with the highest frequency. In TCM it has an action of "calming heart and inducing tranquilisation"It contains β-asarone, α-asarone and other phenylpropenes as well as lignans, along with aporphine-type alkaloids with the essential oil having NMDA receptor antagonist-like action and possibly increases NE, DA and 5-HT, also decreasing the activity of acetylcholinesterase. A water extract demonstrated specific binding to striatal dopamine D1 and D2 receptors and competed with [3H]muscimol for specific binding to the GABA binding site of cortex GABAA receptor-
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A few days in and perhaps the most robust change has been with potential anti-addictive activity, for me being able to say no to smoking which resurged recently and I wasn't able to get on top of (EDIT less sustained anti-addictive potential than I'd hoped). The regulation of neurotrophins, particularly GDNF [1], seems to have quite profound effects on addictive processes, the GDNF pathway implicated in the anti-addictive action of things like ibogaine. Some stability in mood developed over the extreme negative mood states and even some uplift, whilst still having profound motivational deficits and ability to initiate and maintain goal-directed activity. Been trying to have glimmers of sustained attention to focus on tasks like watching short bursts of movies or TV shows which is still incredibly challenging
As the administration via intranasal pathways directly into the olfactory bulb is likely to target the neurotrophic activity directly into the OFC and frontal lobes, it interests me how it could impact severe hypofrontality [2] particularly with regard to OFC functioning where damage can cause neurobehavioural issues
For a long time I've been walking around like a headless chook with aberrant motor functions, this seems to reduce the 'headless chook' wandering a bit
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Thanks for your input and kind words DL. Hope you get some improvement of your residual symptoms.
Initially there's not much robust acute improvement but symptoms were severe at baseline so not expecting quick results. If anything perhaps some destabilisation of mood etc but I sometimes feel that can be a part of the 'solve et coagula' of life. I particularly wonder if, as a significant portion of my symptoms was through an inhalation suicide attempt, this might be a very direct way to target the damaged pathways, particularly into the OFC, quite directly.They did some research using aromatherapy for inhalant abuse, this is like the next level up, intranasal aromatherapy.
A novel approach of substitution therapy with inhalation of essential oil for the reduction of inhalant craving: A double-blinded randomized controlled trial -
Very limited availability of these two
Mind Mend Cognitive Blend
https://pdfhost.io/v/wIuDteWuV_mind_mend
Polyphenol blend
https://pdfhost.io/v/2XXhGA8me_polyphenol_blend-
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I have a small quantity of research material left over from my brief TLC study on it, if anyone is curious to do any complimentary research on it let me know. There are no studies I can find on possible alkaloid constituents yet.
Heteropterys angustifolia - A preliminary TLC study
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Nose-to-brain delivery of asarones for CNS conditions?
Ayurvedic medicine and traditional Chinese medicine (TCM) use Acorus preferably to treat central nervous system (CNS) related diseases such as epilepsy, insanity, mental weakness, or insomnia, Calamus has been widely used internally in both Chinese and Ayurvedic medicine for degenerative central nervous system disorders associated with communication, focus, memory and learning but there are concerns regarding the safety of such orally.The ability of asarones to induce such a broad range of neurotrophic factors (NGF, BDNF, GDNF, CNTF in a dose-dependent manner), alongside other neuroprotective and neurorestorative pharmacological actions, intrigues me.
Pharmacologically, α- and β-asarone at lower doses (<50 mg/kg) exhibits a wide range of therapeutic activities such as antidepressant, antianxiety, anti-Alzheimer, and anti-Parkinson effects [1].Asarones as a therapeutic are limited by poor absolute bioavailability when administered orally, less than 10%, because it is highly lipophilic and has poor solubility in water, coupled with extensive gastrointestinal and/or hepatic first-pass metabolism.
There are concerns potentially harmful effects, such as genotoxicity particularly through accumulation in the liver where "both α- and β-asarone can cause hepatomas and might possess mutagenic, genotoxic, carcinogenic, and teratogenic effects". Because the amounts of asarone accumulated in liver may reflect its hepatotoxicity, there is special significance to reducing the amount of asarone in liver.
Quote"The development of more efficient systems to deliver α- and β-asarone to their biological targets, particularly the brain, might allow for effective localized biological action while minimizing toxicity."
Efforts have been centred on exploring nose-to-brain delivery of asarones, particularly as nanoemulsions [1,2] In humans, 20mg asarone has been added to memantine for AD [3]
Quote"Drugs can travel from the olfactory epithelium in the nasal cavity straight into brain tissue via the olfactory bulb which gives intranasal administration special significance for brain diseases"
"...intranasal administration of asarone showed significant nose-to-brain transport, especially in the olfactory bulb, and such treatment yields equivalent or higher concentrations in other brain tissues compared to intravenous or oral administration"
I'm personally curious as to whether a simple spray of asarones emulsified in water with a polysorbate emulsifier, delivered via a nasal spray bottle may be simple enough to make a readily available nose-to-brain delivery system "polysorbates [are] a promising excipient to increase drug concentration in both plasma and brain via intranasal route".The main beneficial actions of asarones, as described by [1], are summarised as:
" (1) antioxidant properties; (2) the regulation of various neuroprotective signaling pathways; (3) the reduction of aggregate formation and promotion of the clearance of pathogenic protein aggregates; (4) anti-inflammatory properties; (5) the inhibition of microglial activation; (6) the activation of NTFs-mediated neuroprotection; and (7) the modulation of neurotransmitter levels associated with behavioural functions and neuronal cell survival."
Actions of asarones on the CNS, taken from [1]
Normal vs diseased brain aspects
Asarone functions as a neuroprotective effect in both in vivo and in vitro models of neurodegeneration- Enhance BDNF via TrkB and activate the ERK pathway, triggering antidepressant-like effects
- Significantly promoted the expression and secretion of neurotrophins, such as nerve growth factor (NGF), BDNF, and GDNF, in a dose-dependent manner. Also effects on CNTF
- Maintain equilibrium between glutamate and GABA in the hippocampus, enhancing learning and memory abilities. β-asarone induced the high potentiation of GABAARs
-Anxiolytic effects of asarone were partially due to maintaining the balance between excitatory/inhibitory transmissions and attenuating neuronal hyper-excitability of excitatory neurons in the basolateral amygdala.
- modulates microglial morphological dynamics, may functionally relate to its influence on neurogenesis
- Other monoaminergic effects, particularly antidepressant effects mediated by noradrenergic (α1 and α2 adrenoceptors) and serotonergic (particularly, 5-HT1A receptors) systems.
- Enhances tyrosine hydroxylase activity with relevance to Parkinson'sMy current line of thinking is to make an emulsion of a polysorbate emulsifier with calamus oil 1:1 in water and explore that. Any input appreciated.
1:1:2 Calamus EO:polysorbate solubiliser:saline administered by nasal spray has got quite a strong bit of burn to it but not totally intolerable.
Nasal sprays are normally less than 140uL/spray meaing at 25% EO concentration {assume 80% asarones), about 28mg asarone per spray may be possible. Even at that dose, each spray is quite painful but it may be feasible to - via multiple doses scattered through the day - reach a therapeutic dose of asarones intranasally with such.
References:
Balakrishnan, R.; Cho, D.-Y.; Kim, I.-S.; Seol, S.-H.; Choi, D.-K. Molecular Mechanisms and Therapeutic Potential of α- and β-Asarone in the Treatment of Neurological Disorders. Antioxidants 2022, 11, 281. https://doi.org/10.3390/antiox11020281
Lu, J., Fu, T., Qian, Y., Zhang, Q., Zhu, H., Pan, L., Zhang, M. (2014). Distribution of α-asarone in brain following three different routes of administration in rats. European Journal of Pharmaceutical Sciences, 63, 63–70. . https://doi.org/10.3390/10.1016/j.ejps.2014.06.006Pan L, Zhou J, Ju F, Zhu H. Intranasal delivery of α-asarone to the brain with lactoferrin-modified mPEG-PLA nanoparticles prepared by premix membrane emulsification. Drug Deliv Transl Res. 2018 Feb;8(1):83-96. doi: https://doi.org/10.1007/s13346-017-0438-8.
Dong, Haiying; Wu, Shuqin; Hu, Nan; Xing, Guihua (2018) Efficacy of tenuigenin and β-asarone as augmentations for memantine in the treatment of Alzheimer’s disease https://doi.org/10.1097/WNR.0000000000000952
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Following up with a TLC comparison to Tabernaemontana pandacaqui (Banana Bush) seeds
T. pandacaqui | PDF Host -
I'll start to add some items slowly here that are available. PM me if interested.
First up, plain 50g ceremonial cacao hearts (single strong serves) as single or double packs {Edit: only one single heart available]]
Possible small donation to a charity of your choice. Single or double packs
Heart-centred Cacao with Rose, Saffron and Kanna (low dose) ~50g. Please do not combine with pharmaceuticals or MAOI plants etc [Limited quantity available, EDIT: only 2 single hearts available]
Possible small donation to a charity of your choice. Single packs.
Tulsi and Rose tea [EDIT: out of stock]
Possible small donation to a charity of your choice
Functional foods [cognitive and polyphenol blends] still on the way.-
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You'd want the products that are intermediates to ethanol formation (pyruvate/acetaldehyde) to condense with the phenethylamine and under acidic conditions, undergo a Pictet-Spengler reaction to form THIQs (below). It wouldn't be a high conversion rate as conditions wouldn't be optimal but you'd likely get some conversion, which given the potency of the compounds, may be enough
1-Me-THIQ has actually found some putative therapeutic actions, "1-Methyl-1,2,3,4-tetrahydroisoquinoline (1MeTIQ) is an endogenous antidepressant and parkinsonism-preventing substance that demonstrates neuroprotective activity."
I've tried to cover some fermentations of plants here The Science of Fermented Fruits, Veggies and Plant Medicines - Pharmacology, Chemistry & Medicine - The Corroboree (shaman-australis.com)
Yeasts are known for reducing some alkene (C=C) and carbonyl (C=O) compounds, which is more applicable to things like mesembrine-type alkaloids in Sceletium
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This is an interesting concept. In theory, you could get a tetrahydroisoquinoline form from pyruvate/followed by decarboxylation = equiv. acetaldehyde and mescaline like such.
This would bring it's pharmacology potentially more in line with the Lophs. The pharmacology of these THIQ's isn't well studied but they seem to be relatively potent serotonin agonists (nM) for a diverse range of serotonin receptors aside from more classical 5-HT2ARs eg pellotine
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Thanks for the wise input @Ishmael Fleishman.
I tend to think people seeking ceremonial cacao are of a different mindset than tastes alone so may tolerate some differences but have to see
I want to keep it away from business models and involving payment for goods for several reasons, being more a project I self-fund but agree, making it sustainable is essentially an impossible challenge if one does that but we'll see. A project to do, that I value, more than a sustainable business venture, is the aim
Thanks again for the other points -
I've been having a bit of an existential crisis - absolutely bored with existence - as disability robs me of significant ability to do things that I find meaningful and valuable on a wider scale, trying to find things that are worthwhile and fulfilling, yet still achievable. I'm curious as to if there is interest in these sorts of things below? Which ones would be of interest?
Please note: All items are not intended to diagnose or treat any medical condition.
This is just a concept at the moment but I've been exploring some prototypes of plant-based options that may meet unmet needs that may have use to the community. I'm writing here to see firstly what sort of interest there may be in the following options, if there is any and where I should potentially put my efforts into development of options?Even if you have other ideas on things that are legit, I'd like to hear.
I'd be looking to base it on a 'Donation to a greater good' based scheme where for example, one could - at their choice - contribute a donation to a relevant charity as exchange for goods - that would be your part to do and I'd simply trust your end of the deal. If you wanted to, covering postage costs after receiving items would be helpful and maybe help me continue to do more in the way of this sort of thing down the track. Not sure how it's going to work longer term and I'm currently finding the research and development pricey but hopefully once that settles, I can minimise costs
They'd be fairly small samples, just to get an idea if these options potentially worked for you, and if they did, you could then feel free to source ingredients to make it yourself, and optimise if you like, which I'd encourage.
Some of the prototypes I've been exploring:
Mind Mend Cognitive Blend
Ingredients: Ashwagandha, Brahmi, Shankhpushpi, Lion's Mane, Saffron, Mucuna, Ginkgo, White Peony, Rhodiola.
Each level teaspoon (2.7g) provides
Ashwagandha (Withania somnifera) root 675mg
Brahmi (Bacopa monnieri) 675mg
Shankhpushpi (Convolvulus pluricaulis) 675mg
'Neuro Shroom Blend' 675mg
Saffron (Crocus sativus) 20mg
Suggested serving size: up to 2 level tsp (2.7g ea tsp) three times daily
Caution: Not intended to treat any medical condition or replace professional medical advice. Food supplement ONLY. There have been case studies of potential interactions (namely Rhodiola with serotonergics) with some ingredients with pharmaceuticals, please consult your pharmacist for advice.
"...current pharmacotherapeutics for [cognitive impairment] neither cure nor halt cognitive decline; they just delay the worsening cognitive impairment"
A narrative review found "nutrients and phytonutrients may be promising for treating some aspects of cognitive impairment" with highlighted findings of reviewed clinical trials displaying a wide range of results on cognitive function, with some showing promising effects eg Bacopa monnieri, curcumin, Rhodiola rosea, Saffron, Withania somnifera, and xanthines [1].
While conventional Western medicine hasn't made much progress in treating cognitive issues, schools of medicine like Ayruvedic ones might have some clues for good strategies to intervene with for early interventions, or more prophylactically.
As a broader shot-gun approach by utilising a polyherbal formula, the diverse etiology of cognitive issues could potentially be addressed better than the more specific molecular approach adopted commonly in Western medicine. This includes reliance on phytochemical synergies to potentially offer a different, broader and diverse response. That said, as a later intervention in serious cognitive decline, many nutraceuticals offer poor evidence of efficacy.
This is a blend of traditional Ayruvedic herbs: Ashwagandha [2], Brahmi [3], Shankhpushpi [4] - all showing promise in addressing cognitive issues - blended with other options with mounting potential benefits for cognitive issues such as Lion's Mane [5], Saffron [6] and Ginkgo [7], Rhodiola and some other herbs
[1] http://www.ncbi.nlm.nih.gov/pmc/articles/pmc8445631/
[2] https://doi.org/10.1080/19390211.2017.1284970
[3] https://doi.org/10.1089/acm.2008.0018
[4] https://doi.org/10.3389/fphar.2020.00171
[5] https://doi.org/10.1002/ptr.2634
[6] http://dx.doi.org/10.2174/1570159X19666210113144703
[7] https://doi.org/10.3233/jad-215423Terpene Dance Spray
This one is currently hindered by postage issues as it likely falls under flammable goods and can't be posted. That said, if there is demand, I could maybe look into an option not using ethanol, rather an essential oil solubiliser in water to make it post friendly. That said, I don't want to put effort into things that don't meet a need.
It's designed to be a transdermal essential oil spray that I've found quite effective at loosening up to get into a therapeutic dance. I find with significant transdermal administration, I can personally get loose enough to get into the groove. It does however make you reek like a walking diffuser.
Essential oil-based dance spray
Loosen up naturally and feel the good vibes with a symphony of plant-based activesOther items I've been exploring:
Ceremonial Cacao bars
Polyphenol Blend
Trying to utilise rich sources of polyphenols (purple corn anthocyanins, citrus flavonoids etc) to create a broad-spectrum polyphenol blendA 'Golden Paste' option
Tea Blends
If there's interest in these sorts of things, let me know what sort of things would be useful through the poll above.
Much gratitude for any input you can offer.
Have a lovely day.-
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Anyone by chance explored?
Agapanthus campanulatus
QuoteUnspecified parts are used by the Sotho in South Africa to treat people “who have the spirit”, which appears to be a type of mental disturbance (Laydevant, 1932). The Zulu use unidentified species of Agapanthus for inducing visions (imibono) and dreams in South Africa (Nonkazimlo Podile, pers. comm.).
Modified from [1]
- rhizome of A. campanulatus used in the initiation of traditional healers due to the presence of active principles as yuccagenin and agapanthagenin but both of them cause gastrointestinal tract and kidney problems (Ndhlala et al., 2013; Bonokwane et al., 2022).
Triterpenoid saponins are thought to be the main actives of ubulawu such as Agapanthus companulatus. No alkaloids were detected in Agapanthus campanulatus
In vitro assays (ethanol extracts from the leaves) showed good binding affinity to serotonin, dopamine and noradrenaline transporters [2]It is possible that the triterpenoid saponins found in Agapanthus campanulatus and other ubulawu species and their interactions may be responsible for these antidepressant actions, as well as the other reported psychoactive effects [3,4]
References
Ahmed Mohamed Younis, Alshymaa AbdelRahman Gomaa, Alyaa Hatem Ibrahim, Mohamed S.A. Abdelkader, Samar Yehia Desoukey, The genus Agapanthus: A review of traditional uses, pharmacological and phytochemical attributes, South African Journal of Botany, Volume 150, 2022, Pages 1168-1183, ISSN 0254-6299, https://doi.org/10.1016/j.sajb.2022.09.029
Mikael E. Pedersen, Bernadeta Szewczyk, Katarzyna Stachowicz, Joanna Wieronska, Jacob Andersen, Gary I. Stafford, Johannes van Staden, Andrzej Pilc, Anna K. Jäger, Effects of South African traditional medicine in animal models for depression, Journal of Ethnopharmacology, Volume 119, Issue 3, 2008, Pages 542-548, ISSN 0378-8741, https://doi.org/10.1016/j.jep.2008.08.030
Jean-Francois Sobiecki, Psychoactive Ubulawu Spiritual Medicines and Healing Dynamics in the Initiation Process of Southern Bantu Diviners Journal of Psychoactive Drugs, 44 (3), 216–223, 2012 https://doi.org/10.1080/02791072.2012.703101
Bonokwane Melia Bokaeng, Lekhooa Makhotso, Struwig Madeleen, Aremu Adeyemi Oladapo Antidepressant Effects of South African Plants: An Appraisal of Ethnobotanical Surveys, Ethnopharmacological and Phytochemical Studies Frontiers in Pharmacology, 13, 2022 https://doi.org/10.3389/fphar.2022.895286
Options For Mood Stabilzer
in Pharmacology, Chemistry & Medicine
Posted · Edited by Alchemica
Best talking with your Dr but as an adjunct, not to be considered medical advice:
Omega-3's seem pretty mood stabilising in most studies "sources state that omega-3s may have a mood stabilising effect and help with short-term symptoms of bipolar disorder"
Dietary ketosis seems very stabilising, maybe could add some MCTs to your diet if you can't go full keto
Lithium is natural, while high doses are only good suggested under medical supervision, some people find low dose lithium orotate can have some benefits
N-acetyl-cysteine seems to have some 'leveling effects' and evidence for it's use in diverse mental health conditions
5-HTP or tryptophan might level out some emotional volatility
If it's anxious distress, maybe something like oral lavender oil capsules you can get at the chemist which has similar levels of effect size on such as SSRIs and BZDs
I found L-tetrahydropalmatine leveling
Something like theanine? Taurine, Glutamine etc. Calming herbs. Whole range of more calming things out there that might dampen excitatory neurotransmission a bit for you
Considered something like inositol? You need quite high doses and the level of evidence as a mood stabiliser isn't great but it's benign