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Posts posted by Alchemica
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I'll start to add some items slowly here that are available. PM me if interested.
First up, plain 50g ceremonial cacao hearts (single strong serves) as single or double packs {Edit: only one single heart available]]
Possible small donation to a charity of your choice. Single or double packs
Heart-centred Cacao with Rose, Saffron and Kanna (low dose) ~50g. Please do not combine with pharmaceuticals or MAOI plants etc [Limited quantity available, EDIT: only 2 single hearts available]
Possible small donation to a charity of your choice. Single packs.
Tulsi and Rose tea [EDIT: out of stock]
Possible small donation to a charity of your choice
Functional foods [cognitive and polyphenol blends] still on the way.- 1
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You'd want the products that are intermediates to ethanol formation (pyruvate/acetaldehyde) to condense with the phenethylamine and under acidic conditions, undergo a Pictet-Spengler reaction to form THIQs (below). It wouldn't be a high conversion rate as conditions wouldn't be optimal but you'd likely get some conversion, which given the potency of the compounds, may be enough
1-Me-THIQ has actually found some putative therapeutic actions, "1-Methyl-1,2,3,4-tetrahydroisoquinoline (1MeTIQ) is an endogenous antidepressant and parkinsonism-preventing substance that demonstrates neuroprotective activity."
I've tried to cover some fermentations of plants here The Science of Fermented Fruits, Veggies and Plant Medicines - Pharmacology, Chemistry & Medicine - The Corroboree (shaman-australis.com)
Yeasts are known for reducing some alkene (C=C) and carbonyl (C=O) compounds, which is more applicable to things like mesembrine-type alkaloids in Sceletium
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This is an interesting concept. In theory, you could get a tetrahydroisoquinoline form from pyruvate/followed by decarboxylation = equiv. acetaldehyde and mescaline like such.
This would bring it's pharmacology potentially more in line with the Lophs. The pharmacology of these THIQ's isn't well studied but they seem to be relatively potent serotonin agonists (nM) for a diverse range of serotonin receptors aside from more classical 5-HT2ARs eg pellotine
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Thanks for the wise input @Ishmael Fleishman.
I tend to think people seeking ceremonial cacao are of a different mindset than tastes alone so may tolerate some differences but have to see
I want to keep it away from business models and involving payment for goods for several reasons, being more a project I self-fund but agree, making it sustainable is essentially an impossible challenge if one does that but we'll see. A project to do, that I value, more than a sustainable business venture, is the aim
Thanks again for the other points -
I've been having a bit of an existential crisis - absolutely bored with existence - as disability robs me of significant ability to do things that I find meaningful and valuable on a wider scale, trying to find things that are worthwhile and fulfilling, yet still achievable. I'm curious as to if there is interest in these sorts of things below? Which ones would be of interest?
Please note: All items are not intended to diagnose or treat any medical condition.
This is just a concept at the moment but I've been exploring some prototypes of plant-based options that may meet unmet needs that may have use to the community. I'm writing here to see firstly what sort of interest there may be in the following options, if there is any and where I should potentially put my efforts into development of options?Even if you have other ideas on things that are legit, I'd like to hear.
I'd be looking to base it on a 'Donation to a greater good' based scheme where for example, one could - at their choice - contribute a donation to a relevant charity as exchange for goods - that would be your part to do and I'd simply trust your end of the deal. If you wanted to, covering postage costs after receiving items would be helpful and maybe help me continue to do more in the way of this sort of thing down the track. Not sure how it's going to work longer term and I'm currently finding the research and development pricey but hopefully once that settles, I can minimise costs
They'd be fairly small samples, just to get an idea if these options potentially worked for you, and if they did, you could then feel free to source ingredients to make it yourself, and optimise if you like, which I'd encourage.
Some of the prototypes I've been exploring:
Mind Mend Cognitive Blend
Ingredients: Ashwagandha, Brahmi, Shankhpushpi, Lion's Mane, Saffron, Mucuna, Ginkgo, White Peony, Rhodiola.
Each level teaspoon (2.7g) provides
Ashwagandha (Withania somnifera) root 675mg
Brahmi (Bacopa monnieri) 675mg
Shankhpushpi (Convolvulus pluricaulis) 675mg
'Neuro Shroom Blend' 675mg
Saffron (Crocus sativus) 20mg
Suggested serving size: up to 2 level tsp (2.7g ea tsp) three times daily
Caution: Not intended to treat any medical condition or replace professional medical advice. Food supplement ONLY. There have been case studies of potential interactions (namely Rhodiola with serotonergics) with some ingredients with pharmaceuticals, please consult your pharmacist for advice.
"...current pharmacotherapeutics for [cognitive impairment] neither cure nor halt cognitive decline; they just delay the worsening cognitive impairment"
A narrative review found "nutrients and phytonutrients may be promising for treating some aspects of cognitive impairment" with highlighted findings of reviewed clinical trials displaying a wide range of results on cognitive function, with some showing promising effects eg Bacopa monnieri, curcumin, Rhodiola rosea, Saffron, Withania somnifera, and xanthines [1].
While conventional Western medicine hasn't made much progress in treating cognitive issues, schools of medicine like Ayruvedic ones might have some clues for good strategies to intervene with for early interventions, or more prophylactically.
As a broader shot-gun approach by utilising a polyherbal formula, the diverse etiology of cognitive issues could potentially be addressed better than the more specific molecular approach adopted commonly in Western medicine. This includes reliance on phytochemical synergies to potentially offer a different, broader and diverse response. That said, as a later intervention in serious cognitive decline, many nutraceuticals offer poor evidence of efficacy.
This is a blend of traditional Ayruvedic herbs: Ashwagandha [2], Brahmi [3], Shankhpushpi [4] - all showing promise in addressing cognitive issues - blended with other options with mounting potential benefits for cognitive issues such as Lion's Mane [5], Saffron [6] and Ginkgo [7], Rhodiola and some other herbs
[1] http://www.ncbi.nlm.nih.gov/pmc/articles/pmc8445631/
[2] https://doi.org/10.1080/19390211.2017.1284970
[3] https://doi.org/10.1089/acm.2008.0018
[4] https://doi.org/10.3389/fphar.2020.00171
[5] https://doi.org/10.1002/ptr.2634
[6] http://dx.doi.org/10.2174/1570159X19666210113144703
[7] https://doi.org/10.3233/jad-215423Terpene Dance Spray
This one is currently hindered by postage issues as it likely falls under flammable goods and can't be posted. That said, if there is demand, I could maybe look into an option not using ethanol, rather an essential oil solubiliser in water to make it post friendly. That said, I don't want to put effort into things that don't meet a need.
It's designed to be a transdermal essential oil spray that I've found quite effective at loosening up to get into a therapeutic dance. I find with significant transdermal administration, I can personally get loose enough to get into the groove. It does however make you reek like a walking diffuser.
Essential oil-based dance spray
Loosen up naturally and feel the good vibes with a symphony of plant-based activesOther items I've been exploring:
Ceremonial Cacao barsPolyphenol Blend
Trying to utilise rich sources of polyphenols (purple corn anthocyanins, citrus flavonoids etc) to create a broad-spectrum polyphenol blendA 'Golden Paste' option
Tea Blends
If there's interest in these sorts of things, let me know what sort of things would be useful through the poll above.
Much gratitude for any input you can offer.
Have a lovely day.- 1
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Anyone by chance explored?
Agapanthus campanulatus
QuoteUnspecified parts are used by the Sotho in South Africa to treat people “who have the spirit”, which appears to be a type of mental disturbance (Laydevant, 1932). The Zulu use unidentified species of Agapanthus for inducing visions (imibono) and dreams in South Africa (Nonkazimlo Podile, pers. comm.).
Modified from [1]
- rhizome of A. campanulatus used in the initiation of traditional healers due to the presence of active principles as yuccagenin and agapanthagenin but both of them cause gastrointestinal tract and kidney problems (Ndhlala et al., 2013; Bonokwane et al., 2022).
Triterpenoid saponins are thought to be the main actives of ubulawu such as Agapanthus companulatus. No alkaloids were detected in Agapanthus campanulatus
In vitro assays (ethanol extracts from the leaves) showed good binding affinity to serotonin, dopamine and noradrenaline transporters [2]It is possible that the triterpenoid saponins found in Agapanthus campanulatus and other ubulawu species and their interactions may be responsible for these antidepressant actions, as well as the other reported psychoactive effects [3,4]
References
Ahmed Mohamed Younis, Alshymaa AbdelRahman Gomaa, Alyaa Hatem Ibrahim, Mohamed S.A. Abdelkader, Samar Yehia Desoukey, The genus Agapanthus: A review of traditional uses, pharmacological and phytochemical attributes, South African Journal of Botany, Volume 150, 2022, Pages 1168-1183, ISSN 0254-6299, https://doi.org/10.1016/j.sajb.2022.09.029
Mikael E. Pedersen, Bernadeta Szewczyk, Katarzyna Stachowicz, Joanna Wieronska, Jacob Andersen, Gary I. Stafford, Johannes van Staden, Andrzej Pilc, Anna K. Jäger, Effects of South African traditional medicine in animal models for depression, Journal of Ethnopharmacology, Volume 119, Issue 3, 2008, Pages 542-548, ISSN 0378-8741, https://doi.org/10.1016/j.jep.2008.08.030
Jean-Francois Sobiecki, Psychoactive Ubulawu Spiritual Medicines and Healing Dynamics in the Initiation Process of Southern Bantu Diviners Journal of Psychoactive Drugs, 44 (3), 216–223, 2012 https://doi.org/10.1080/02791072.2012.703101
Bonokwane Melia Bokaeng, Lekhooa Makhotso, Struwig Madeleen, Aremu Adeyemi Oladapo Antidepressant Effects of South African Plants: An Appraisal of Ethnobotanical Surveys, Ethnopharmacological and Phytochemical Studies Frontiers in Pharmacology, 13, 2022 https://doi.org/10.3389/fphar.2022.895286 -
5 hours ago, Ishmael Fleishman said:
Alchemica - the cuttings are doing well green and lush with some going into bloom and all - however the Sceletium emarcidum cuttings are not looking so good - their is obvious browning and drying out have you got any advice? Will it come right or do I need to do something different?
These I find tend to get quite battered before they look slightly better as cuttings but they seem quite hardy. I think the lot of emarcidum I sent maybe wasn't in the best of health for cutting as it was flowering etc. I can maybe send more if you need it, or try to root some up for you
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Quote
Can you recommend a supplier of ceremonial grade cacao?
I've used two, one that was sold as 'ceremonial grade cacao' was nothing particularly noteworthy. The other, more expensive, was a bit richer and nicer and available at the local market in whatever quantity one wants https://houseofhealthcollective.com.au/lines/ceremonial-cacao-chunks but it comes with the price-tag
QuoteCacao does not seem to get much traction as a psychoactive drug. Our cultural consumption of hyper processed diluted and sachrine chocolate maybe blinding us to the possible potential of cacao.
I agree, particularly initially I had some quite profound experiences using high dose cacao powder/paste
5 hours ago, Ishmael Fleishman said:@Alchemica what are your thoughts of mixing cacao with harmala?
Haven't tried it but would guess it could be rather potent
More on the β-carbolines in Cacao [1]
QuoteWe have previously reported that several foods and fermented alcoholic beverages contain appreciable amounts of two of those THβCs found in chocolates, THCA and MTCA, reaching up to several mg/kg (Herraiz et al., 1993, Herraiz, 1996-2000). Interestingly, the concentration of THCA and MTCA in chocolate and cocoa is comparable to that of alcoholic beverages such as wine, beer, and liquor, which contain a relatively high amount of those compounds.The origin of these tetrahydro-β-carbolines is a reaction involving L-tryptophan and aldehydes that are present or otherwise released during the processing of foods and beverages. Its chemical formation depends on the amount of precursors, storage time, pH, temperature, and processing conditions (Herraiz and Ough, 1993; Herraiz, 1996).The same reaction is likely to occur in chocolates that suffer a fermentation from cacao beans and heating processes. Then, it is expected that serotonin, L-tryptophan, and tryptamine afford the corresponding THβCs (6OHMTHβC, MTCA, and MTHβC) through a Pictet-Spengler condensation with acetaldehyde
The biological significance of tetrahydro-β-carbolines and β-carbolines is related to their potential pharmacological actions on the nervous system, playing a role as neuromodulators via effects on monoamine oxidase (MAO), biogenic amine (serotonin) uptake/release, and benzodiazepine receptor binding. Then, these compounds exogenously supplied, or hypothetically produced in vivo, might become bioactive, exhibiting behavioral and/or toxicological implications. In this regard, it is very likely that part of the β-carbolines found in the human tissues and fluids have a dietary origin.
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On 22/10/2023 at 7:20 AM, Ishmael Fleishman said:
The ceremonial grade stuff is not easy to get were I am and I have just not been able to justify the cost at this time - however I am keen to try if their is any difference.
If I get the chance, I'll grab you some. I think it's easy enough to get decent effects with the cheap powder but it's not as 'in' as having Peruvian ceremonial grade cacao
I did a lot of experimenting with Cacao. It seems quite a useful medicine particularly for cognitive stuff, and in the shorter term as a mood lift. I was playing around with lots of fermenting and other things trying to boost effects but in the long run, simple seems best. Some popular blends were Sceletium, Saffron and Cacao and a few others
QuoteThe broader cognition-enhancing effects seem dose-dependent, sustained, cumulative and in part, due to cacao flavonols and other constituents that act in a more long-lasting way.Cacao is an interesting nutraceutical tool to protect human cognition and counteract different types of cognitive decline - research investigating the relations between cacao and cognition shows dose-dependent improvements in general cognition, attention, processing speed, and working memory [1]. The CNS effects of cacao have been divided into several components by various authors [2].There is a large amount of scientific evidence that the flavonoids, more in particular cacao flavonols, are involved in the cognition-enhancing effects. Epicatechin, the most abundant flavanol in cacao, displays various beneficial effects on the CNS by stimulating perfusion (via a nitric oxide mediated pathway), angiogenesis, and neurogenesis (BDNF-TrkB). It induces changes in neuron morphology, especially in regions involved in memory and learning. These effects should be cumulative. The metabolites of the larger polyphenols also likely stimulate BDNF mediated processes.At the second level, the methylxanthines caffeine and theobromine have additive and maybe synergistic effects on cognition and alertness, although the role of theobromine remains unclear. That said, it seems the theobromine improves working memory [3] via upregulation of BDNF, also an effect that likely builds over time, rather than being acute.At the third and gradually more specific level, the tetrahydroisoquinoline alkaloids, more in particular salsolinol, may exert additive or synergistic activities.The β-carbolines are so common in foods as they form in condensation reactions between tryptophan and carbonyl compounds/breakdown products of sugars, which condense in a Pictet-Spengler reaction (often undergoing decarboxylation on roasting). Practically fermenting and roasting many foods will form some (and this seems to be their origin in Cacao), the main ones that seem to be often seen are (nor)harman, which results in measurable MAO-A inhibition from repeated coffee drinking, and tobacco use, which likewise results in significant MAO-A inhibition over long-term use "coffee is the most important exogenous source of these alkaloids in addition to cigarette smoking." [1].
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It's pretty hard to get efficacy matching benzodiazepines IMO, even if the plant-based options retain some efficacy in treating symptoms. Also, if there's GABAergic tolerance through use of pharmaceutical GABAergics or drinking etc in prior history, most of these can seem comparatively mild/insufficient. Also, I wouldn't even consider relying on them for serious medical conditions eg seizure control
I've in the past tried to rank subjective potency (which considering all my brain has been through shouldn't be taken as representative of normal) of some here as anxiolytics (note: not all GABAergic MoA):
Lemon balm < Lower dose Passiflora < Lower dose skullcap < Zizyphus seed < Hops = Valerian < Oral lavender oil 80-160mg = lower dose kava = low dose CBD < Erythrina mulungu < Higher dose 25g+ Passiflora < CBD 600mg + < Higher dose skullcap < High dose kava.
In general the flavonoid GABAergic plants can seemingly have some decent GABAA mediated therapeutic effects but often without the abuse potential seen with BZDs eg baicalinThat said, sometimes maintaining efficacy can be challenging with such and I can't say that the flavonoid GABAergics tend to have the "enjoyable" nature of BZDs
There seems to be distinction between seeking actual symptom reduction eg. anxiolysis vs. desiring inebriation that can make people who enjoy GABAergics dismiss some plant options IMO
Then there's things like tetrahydropalmatine which through non-GABAergic mechanisms seems to have potent muscle relaxing activity
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3 minutes ago, Yeti101 said:
Man, you’ve been keeping busy!
No rest for fiends like me
I've tried to compile lots of my research into a website for anyone who's bored out of their brains/curious.
Alchemica's Research Lair - Phytopharmacology (site123.me)- 3
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This area has been of interest to me in the past, even though I'm not into bioassaying these days. Here's a literature review and some research
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Tried to briefly explore Tabernaemontana undulata to see if it has potential merit for anti-addictive properties.
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2 hours ago, fyzygy said:
Is Sceletium emarcidum comparable to tortuosum? Haven't come across that one before.
It's said by some including herbalistics to be "valued as highly as S. tortuosum in Southern Africa by different tribes and makes a very good Kougoed product". and I vaguely remember Torsten (but don't quote me) making mention of it not really mattering if you grow emarcidum vs tortuosum. Personally, there's something nicer about tortuosum but my brain isn't a good test subject. Phytochemically, it seems the emarcidum is 4'-O-demethylated mesembrine-type alkaloids (phenolic alkaloids) over the parent mesembrine-type alkaloids. It seems to root up a lot easier from cuttings, grows quickly and grows a lot easier in many climates. That said, some people have fermented up emarcidum and not noted much effect but even tortuosum can be hit and miss with some people.
QuoteI had no luck rooting the lampranthus you sent a while back. But D. bosseranum seed has yielded a cluster of tiny seedlings.
Yeah I have varied success with different cuttings at the best of times but good to hear what's worked for you.
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26 minutes ago, fyzygy said:
What does "true form" mean?
My botanical nomenclature probably sucks but that's just to distinguish it from the common hybrids that often get sold as Aptenia cordifolia (eg red flowered varieties). This is the one (sets seed too)
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I've devoted quite a bit of time to researching succulents so would like to share the love.
Can spare a couple (2) packs [Edit: one left] of free mixed succulents to the first couple of people interested (reply here and I'll get back to you)
1. Sceletium tortuosum cuttings2. Sceletium emarcidum cuttings
3. Delosperma bosseranum mature plants
4. Delosperma echinatum cuttings5. Trichodiadema stellatum cuttings
6. Lampranthus spectabilis (red) cuttings
7. Mesembryanthemum (Aptenia) cordifolium (purple) true form seedlings/cuttings. Can also include others including Aptenia haeckeliana if interested
8. maybe some Lampranthus aureus cutting
No WA/TAS
Something like this:
Some of them can be a challenge to root up but see how you go. Only express interest if you're dedicated and keen please.
I'll include postage.- 4
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Don't think I have any M. crystallinum seed left from when I grew it and I found it hard to propagate from cuttings as it's so fleshy but it's pretty easy to grow from seed so I'd personally just grab some cheap seeds eg Ice plant seeds | The Seed Collection
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Nice summary, well done.
As another area that's been researched (and patented):
We also see immunological benefits, ultra-potent blockade of proinflammatory markers like TNF-α at pM levels (sub-psychoactive doses) with some 5-HT2AR agonists like ®-DOI which is promising on many levels, it plays a key role in inflammation, its production and signaling contribute to many inflammation related diseases.
TNF-α and TNF-α receptor-mediated inflammatory pathways have been strongly implicated in a number of diseases including atherosclerosis, rheumatoid arthritis, psoriasis, type II diabetes, irritable bowel syndrome, Crohn's disease, and septicemia (e.g., Reimold, 2002; Popa et al., 2007; Williams et al., 2007). Significantly, TNF-α and other cytokine induced inflammatory pathways also have been linked to psychiatric conditions such as depression and bipolar disorder (Dunn et al., 2005; Kim et al., 2007), as well as schizophrenia (Saetre et al., 2007), and neurodegenerative diseases like Alzheimer's and Parkinson's disease and stroke (Tweedie et al., 2007).US9642819B2 - Low dosage serotonin 5-HT2A receptor agonist to suppress inflammation - Google Patents
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35 minutes ago, Ishmael Fleishman said:
So are you saying that having to many 5-HT2A receptors can actually make you more depressed/suicidal? Is the quantity of 5-HT2A receptors determined by genetics or environment or both? I come from a family of depressed people however we all lived in a very bad environment - inter-generational political violence and racial suppression - aka apartheid.
I think I would easily have a Bmax value. Can you get easily tested for Bmax value?
Either overexpression of 5-HT2Rs with increased binding density or an altered regional expression of 5-HT2s seems to be common. There are polymorphisms of the 5-HT2A gene that can lead to changes in the density of those receptors but it more likely seems to be a complex interplay of genetics, environment and life-experiences that shape such an outcome [1]. There's likely epigenetic effects where adverse trauma could be transmitted transgenerationally, leading to an impact on, in part, the serotonin system.
QuoteI think I would easily have a Bmax value. Can you get easily tested for Bmax value?
Not easily, it would likely only be if you're part of a special research study such would be possible
QuoteHowever with such a short half-life Sandomigran. Should it not have any attenuation after a few days of Sandomigran abstinence?
Depending how potent an antagonist it is of the 5-HT2A receptor. Often as a "washout" a period of greater than 5 half-lives is used to estimate the practically total elimination of a drug and the cessation of it's pharmacological effects
"Starting from a steady state, 5 half-lives will remove 97% or a drug; whereas 10 half-lives will remove 99.9% of a drug"
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2 hours ago, Ishmael Fleishman said:
In the last year I have started getting migraines.
I was given rizatriptan (Maxalt, Maxalt-MLT) this helps with the acute symptoms. However I have just hesitantly started Sandomigran as a preventative. Since rizatriptan by itself effective I have to use four tabs a day everyday to keep the migraines away.
Now looking at the wiki page Sandomigran got me asking a few questions.
I am not a neuropharmacologist so forgive my silly questions.
Sandomigran is an antiserotonin medication which has been effective in in the treatment of serotonin syndrome or MDMA overdose.
From my limited understanding Mescaline is very similar to MDMA. Does this means that Sandomigran would inhibit the binding of Mescaline to the 5-HT2A receptor? Sandomigran half life is 23 hours.
Secondly could it be used to end a challenging mescaline experience being a antiserotonergic medication? Or to help come down from mescaline experience to help with sleep like some people use benzos.
Thirdly question is Sandomigran acts as an antidepressant, or for the treatment of anxiety or social phobia. The classical model says that depression is caused by a lack of serotonin - we know this to be largely incorrect. How can a Serotonin receptor antagonist in the classical model of depression treat depression if it reduces the binding of serotonin?
Things like ketanserin have been used as 5-HT2AR antagonists to block/attenuate the 'psychotomimetic' effects of psychedelics but interestingly, the combined effects of a 5-HT2AR antagonist and classical hallucinogens seems to retain some of the therapeutically beneficial effects ie antidepressant and some neural effects [1] so it's likely there would be attenuation of the hallucinogenic effects by sandomigran, particularly with a less potent agonist like mescaline (cyproheptadine which is related is OTC and probably would do the same). Similarly, olanzapine with decent affinity to 5-HT2ARs (along with D2Rs) seems to be used by some as an antipsychotic 'trip kill' [2] and is often conventional medicine's go to, to attenuate a bad trip/psychotic reactions. That said other schools of thought suggest the trip should not be aborted with such and instead benzodiazepines used as an anxiolytic to support a less anxiety-provoking reaction and social support be used more.
Mescaline is quite a 'shotgun' pharmacologically, with diverse binding profiles aside from 5-HT2 agonism ie adrenergic affinity etc. The stimulant effects from adrenergic etc activity might be somewhat attenuated by the antihistaminergic activity of sandomigran.
ie Mescaline has strong affinity [3] to 4.00 Alpha2C, 3.97 5ht2b, 3.61 5ht1a, 3.44 Imidazoline1, 3.16 5ht1e, 2.92 Alpha2A receptors much more so than 5-HT2ARs.'
Serotonin antagonists particularly 5-HT2 antagonists seem to be used in depression (think things like mirtazapine, which has that as a partial mechanism of action) as antagonism of the 5-HT2 receptor can have some pro-dopaminergic effects. Similarly, there are some PET studies linking depression and suicidality to overly high densities of 5-HT2 receptors, and it is thought one of the therapeutic effects of 5-HT2A agonists on depression (so too SSRIs) is to downregulate the excessively dense level of 5-HT2Rs, a similar outcome can be achieved through 5-HT2 antagonism.
The density (Bmax) of 5-HT2A receptors was significantly higher (by 39%) in depressed patients than in controls. Suicidal patients had significantly higher Bmax values than controls or non-suicidal patients. [4]
QuoteLastly does anyone have any experience with herbal based Treatments for Migraines?
Not personal experience but I've heard of people using feverfew which has some evidence base for use. You might want to consider such.
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Been trying to find answers to whether Bobinsana bark should be treated as a potential MAOI due to possible β-carbolines or if the modern guides are correct in stating:
Quote"There are some rumors about Bobinsana containing psychoactive alkaloids however these are completely unproven by any lab test and the effects of Bobinsana do not coincide at all with the effects of the rumored alkaloids."
Quote"...it is generally believed species of Calliandra do not produce alkaloids, they are characterised instead by the synthesis of non-protein amino acids which are pipecolic acid and their derivatives"
Here's some very preliminary TLC results and a write-up
Note: The initial UV fluorescent band was only visible with one wavelength light and a more typical UV light failed to show it, contrary to more common β-carbolines which were strongly visible
If anyone has input that would be appreciated.- 1
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Thanks for the interest. All done for now.
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A preliminary TLC study of Tabernaemontana undulata, it's phytochemistry and possible psychopharmacology
in Pharmacology, Chemistry & Medicine
Posted
Following up with a TLC comparison to Tabernaemontana pandacaqui (Banana Bush) seeds
T. pandacaqui | PDF Host