Happy Cadaver Posted January 18, 2006 I just received Ed Dunkel's alkaloid bearing plants book (thanks ed ) and it list Alstonia constricta as containing both reserpine and alpha-yohimbine. I knew about the reserpine but not the alpha-yohimbine, although it does not state in which plant part they isolated it from. Searching for this compound i came up with the following: 5) Yohimbe alkaloid is a MAOI An alkaloid found in both yohimbe and East Indian Snakeroot (Rauwolfia serpentina) named rauwolscine or alpha-yohimbine (an isomer of yohimbine) was found to inhibit the enzyme monoamine oxidase. The mild MAOI type effects of yohimbe bark have been anecdotally reported for years but now a specific alkaloid has shown measurable activity in the rat liver. It was found that the MAOI activity of alpha-yohimbine works by its association with a specific type of receptor called an imidazoline I-2 site. This appears to be distinct from the more typically recognized type of MAO inhibition such as that caused by harmaline or pargyline. Just made me think of Folias talking about unknown native MAOIs... Share this post Link to post Share on other sites
Ed Dunkel Posted January 18, 2006 I just received Ed Dunkel's alkaloid bearing plants book (thanks ed ) Good to see you are enjoying the book Share this post Link to post Share on other sites
Happy Cadaver Posted January 18, 2006 Good to see you are enjoying the book I love to sit down and read a good reference book ^_^. Share this post Link to post Share on other sites
Happy Cadaver Posted January 18, 2006 I think i'll just go for my 1000 post now.... Share this post Link to post Share on other sites
Happy Cadaver Posted January 18, 2006 almost there. with that book Ed, how accurate do you think it still is? It seems to be pretty good, a lot of good work was done from the 50's - 70's in reagrds to alkaloids Share this post Link to post Share on other sites
Happy Cadaver Posted January 18, 2006 :saufen2: btw we've got heaps of A. constricta growing on our property and the local area if there is some interest in the bark. I tried it recently and it is unbelievably bitter, leaves a lingering bitterness. Was good for fevers and influenza evidently. Share this post Link to post Share on other sites
black Posted January 18, 2006 can i please get a copy ed Share this post Link to post Share on other sites
Ed Dunkel Posted January 19, 2006 (edited) name='black' date='Jan 18 2006, 12:33 PM' post='80978']can i please get a copy ed Nope, none left (only my own copy), sorry Maybe Torsten can set up a library through his research station ;) Books could be shared. with that book Ed, how accurate do you think it still is? I would think it is generally quite ok but I have noticed some inconsistencies in regards to recent work. But then that is to be expected from older research. It's always best to check several sources. But I like the way it lists the plants out and the nummerous entries. Edited January 19, 2006 by Ed Dunkel Share this post Link to post Share on other sites
apothecary Posted January 22, 2006 Experimenting with this stuff may be a bit dodgy, reserpine has permanent effects on brain receptors. Share this post Link to post Share on other sites
Happy Cadaver Posted January 22, 2006 Reserpine is in the roots not stem bark. Share this post Link to post Share on other sites
