Alchemica Posted April 5, 2016 (edited) Battling another round of unrequited love so a mood stabiliser would be nice I sort of like valproate acutely but haven't tried other voltage-gated sodium channel blockers. Aside from the anxiolytic, anticonvulsant and antimanic effects, are they 'interesting'? Lacosamide is Schedule V...Antimanic-like effects of ®-(-)-carvone and (S)-(+)-carvone in mice.Carvone is a monoterpene that is present in spearmint (Mentha spicata) and caraway (Carum carvi) essential oils and has been shown to have anticonvulsant effects, likely through the blockade of voltage-gated sodium channels, and anxiolytic-like effects. Considering that some anticonvulsants that blocked voltage-gated sodium channels (e.g., sodium valproate and carbamazepine) exert clinical antimanic effects, the aim of the present study was to evaluate ®-(-)-carvone and (S)-(+)-carvone in animal models of mania (i.e., hyperlocomotion induced by methylphenidate and sleep deprivation). Mice that were treated with methylphenidate (5mg/kg) or sleep-deprived for 24h using a multiple-platform protocol exhibited an increase in locomotor activity in an automated activity box. This effect was blocked by pretreatment with acute ®-(-)-carvone (50-100mg/kg), (S)-(+)-carvone (50-100mg/kg), and lithium (100mg/kg, positive control). These doses did not alter spontaneous locomotor activity in the methylphenidate-induced experiments while (S)-(+)-carvone decreased spontaneous locomotor activity in sleep deprivation experiment, indicating a sedative effect. Chronic 21-day treatment with ®-(-)-carvone (100mg/kg), (S)-(+)-carvone (100mg/kg), and lithium also prevented methylphenidate-induced hyperactivity. The present results suggest that carvone may have an antimanic-like effect. Edited April 5, 2016 by Alchemica 3 Share this post Link to post Share on other sites
waterboy 2.0 Posted April 5, 2016 40 to 50% of the oil content of Dill seeds is carvone (also has d-Limonene and Phellandrene) Total volatile oil content of Dill seeds is 2 to 5% "...the name dill comes from an Old Norse word, dilla , meaning "lull", since they used it to quiet crying babies". Spices and Seasonings: A food technology Handbook (2nd Ed) (2002). Tainter, D and Grenis, A. 3 Share this post Link to post Share on other sites
