Tabernaemontana cerifera

[tripsis]

Does anyone have reliable information pertaining to whether Tabernaemontana cerifera (syn. Pagiantha cerifera) contains iboga alkaloids and if so, what part of the plant they are present in? I've found a couple of references stating that it does, but no information beyond that. Apparently Pharmacotheon, by Ott and Hoffman, mentions it, but I don't have the book, nor do I know whether it elaborates on it or not.

[CβL]

Sorry for the bad typesetting. Have you seen this before?:

The genus Pagiantha has not previously been seriously investigated, although

the presence of alkaloids in the leaves of P. cerifera M gf. (Tabernaemontana

cerifera Panch. et Seb.) has been noted.' Extraction of these leaves has now

yielded (-)-voacangine, (- )-voacangine hydroxy-indolenine, and(- )-ibogaine,

while the seeds of P. macrocarpa(Jack) Mgf. (Ervatamia macrocarpaM e r r i l l=T.

macrocarpaJack) have been shown

to contain(- )-voacangine, coronaridine,

and voacangine hydroxy-indolenine.

I'm just downloading the file now to check their reference for that study.

Edit: This is the study referenced by that quote

132 A. Harmouche, H. Mehri, M. Koch, A. Rabaron, M. Plat, and T. SCvenet, Ann. pharm. franc., 1976,

http://www.unboundmedicine.com/medline/ebm/record/970873/full_citation/%5BPlants_of_New_Caledonia__XXXIX__Alkaloids_of_leaves_of_Pagiantha_cerifera_Mrgf__Apocynacae_%5D

Edited February 8, 2011 by bluntmuffin

[tripsis]

I have not. Could I get a copy of that article off you?

[CβL]

I'm attempting to get the analytical study of the species in question, but it's in French... and I can't seem to find the full-text.

This is the original title:

Plantes de Nouvelle-calédonie XXXIX. Alcaloïdes des feuilles de Pagiantha cerifera Mrgf. (Apocynacées)

Maybe somebody with more ability to find french articles can help. :S

The first quote comes from here:

http://www.scribd.com/doc/35982296/The-Alkaloids-Volume-8-1978-A-Review-of-Chemical-Literature-Specialist-Periodical-Reports-IsBN-0-85186-327-2-0851863272-IsSN-0305-9707-03059

Here is a 'literature review' which is VERY helpful as it collates all the information together on Tabernaemontana, and it's more up-to-date (1984):

http://www.yourfilehost.com/media.php?cat=other&file=Tabernaemontana.pdf

Edit:

This is the ethnobotanical notes -

T. cerifera

New Caledonia: The wax covering the buds is readily collected for use by

melting it with hot water [ 21,265 1. The macerate of the bark is a drastic

purgative [ 2651.

So... it might be even more gut-wrenching than T. Iboga.

Edited February 8, 2011 by bluntmuffin

[tripsis]

Drastic purgative. Sounds unpleasant... Still, that only mentions the bark. The info in the Scribd link mentions the leaves containing the alkaloids. I wonder if there are any published reports with percentages of each alkaloid? I should try to get Snu's book out of storage to see if there is anything about it in there.

Thanks for your help by the way.

[CβL]

No problem.

I am interested in this topic as well, and decided to have a look when you posted this topic. I really recommend that second literature review for a good read. There's a lot of leads in there. Heaps of compounds that act similarly to ibogaine in rat studies (not that that can tell a whole lot). And there's also a large amount of other T. species worth looking at.