tripsis Posted February 8, 2011 Does anyone have reliable information pertaining to whether Tabernaemontana cerifera (syn. Pagiantha cerifera) contains iboga alkaloids and if so, what part of the plant they are present in? I've found a couple of references stating that it does, but no information beyond that. Apparently Pharmacotheon, by Ott and Hoffman, mentions it, but I don't have the book, nor do I know whether it elaborates on it or not. Share this post Link to post Share on other sites
CβL Posted February 8, 2011 (edited) Sorry for the bad typesetting. Have you seen this before?: The genus Pagiantha has not previously been seriously investigated, althoughthe presence of alkaloids in the leaves of P. cerifera M gf. (Tabernaemontana cerifera Panch. et Seb.) has been noted.' Extraction of these leaves has now yielded (-)-voacangine, (- )-voacangine hydroxy-indolenine, and(- )-ibogaine, while the seeds of P. macrocarpa(Jack) Mgf. (Ervatamia macrocarpaM e r r i l l=T. macrocarpaJack) have been shown to contain(- )-voacangine, coronaridine, and voacangine hydroxy-indolenine. I'm just downloading the file now to check their reference for that study. Edit: This is the study referenced by that quote 132 A. Harmouche, H. Mehri, M. Koch, A. Rabaron, M. Plat, and T. SCvenet, Ann. pharm. franc., 1976, http://www.unboundmedicine.com/medline/ebm/record/970873/full_citation/%5BPlants_of_New_Caledonia__XXXIX__Alkaloids_of_leaves_of_Pagiantha_cerifera_Mrgf__Apocynacae_%5D Edited February 8, 2011 by bluntmuffin Share this post Link to post Share on other sites
tripsis Posted February 8, 2011 I have not. Could I get a copy of that article off you? Share this post Link to post Share on other sites
CβL Posted February 8, 2011 (edited) I'm attempting to get the analytical study of the species in question, but it's in French... and I can't seem to find the full-text. This is the original title: Plantes de Nouvelle-calédonie XXXIX. Alcaloïdes des feuilles de Pagiantha cerifera Mrgf. (Apocynacées) Maybe somebody with more ability to find french articles can help. :S The first quote comes from here: http://www.scribd.com/doc/35982296/The-Alkaloids-Volume-8-1978-A-Review-of-Chemical-Literature-Specialist-Periodical-Reports-IsBN-0-85186-327-2-0851863272-IsSN-0305-9707-03059 Here is a 'literature review' which is VERY helpful as it collates all the information together on Tabernaemontana, and it's more up-to-date (1984): http://www.yourfilehost.com/media.php?cat=other&file=Tabernaemontana.pdf Edit: This is the ethnobotanical notes - T. ceriferaNew Caledonia: The wax covering the buds is readily collected for use by melting it with hot water [ 21,265 1. The macerate of the bark is a drastic purgative [ 2651. So... it might be even more gut-wrenching than T. Iboga. Edited February 8, 2011 by bluntmuffin Share this post Link to post Share on other sites
tripsis Posted February 8, 2011 Drastic purgative. Sounds unpleasant... Still, that only mentions the bark. The info in the Scribd link mentions the leaves containing the alkaloids. I wonder if there are any published reports with percentages of each alkaloid? I should try to get Snu's book out of storage to see if there is anything about it in there. Thanks for your help by the way. Share this post Link to post Share on other sites
CβL Posted February 8, 2011 No problem. I am interested in this topic as well, and decided to have a look when you posted this topic. I really recommend that second literature review for a good read. There's a lot of leads in there. Heaps of compounds that act similarly to ibogaine in rat studies (not that that can tell a whole lot). And there's also a large amount of other T. species worth looking at. Share this post Link to post Share on other sites