I have bipolar disorder, or manic depression. I get mania really bad and sometimes it feels as if im od'ing on speed.. when I dont sleep and eat it gets REALLY bad, I can see where they are coming from. Im now on Epilim 500mg a day, Olanzapine 20mg a night, St Johns Wort 1.8gm's 3 times a day. This keeps me stable, also eating and sleeping play BIG roles in my sanity. Good read, thanks for bringing this to my attention Torsten.