The link between weed and schizophrenia is way more complicated than we thought

[CLICKHEREx]

http://www.bluelight.org/vb/threads/727085-The-link-between-weed-and-schizophrenia-is-way-more-complicated-than-we-thought

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Drugs in the Media

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Location "Darkness cannot be dissipated with more darkness. More darkness will make darkness thicker. Only light can dissipate darkness. Violence and hatred cannot be removed with violence and hatred." - Thich Nhat Hanh

Posts 6,279 Yesterday 19:13 Study finds genetic overlap between cannabis use and schizophrenia

The association between marijuana and schizophrenia is historically fraught. In the 1960's and 1970's, scientists thought that smoking weed could trigger psychosis in just about anyone. Today, these findings are more nuanced, but researchers still think that cannabis can trigger schizophrenia in people who are predisposed to the disease meaning those with family histories of the disorder. Yet, in the last decade, some scientists have actually started to look at the effect in reverse. The resulting studies suggest that the neurobiology underlying schizophrenia might also put people affected by the disorder at increased risk for smoking pot. But these results haven't garnered nearly as much attention as studies suggesting the opposite.

Now, a new study, published today in Molecular Psychiatry, lends further support to the idea that schizophrenia plays a role in an individual's likelihood of smoking weed, by showing that the genetic variants predicting schizophrenia can also be used to predict a person's tendency to smoke pot, regardless of their mental health history. This, researchers say, demonstrates that the causal relationship between cannabis use and schizophrenia might not be clear cut, and that at least a small part of the association might be caused by genetic overlap, where the same genes that predispose certain people to enjoying weed might also predispose others to developing schizophrenia or both.

To tease apart this relationship, researchers took genetic data from recently published studies of schizophrenia, and identified genetic variants associated with the disease. Then, they applied that information to a random sample of about 2,000 healthy Australians to see if those variants could also predict cannabis use.

cont at

http://www.theverge.com/2014/6/24/58...mplicated-than DiTM Guidelines DiTM Videos Thread BLUA

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#2 pmoseman View Profile View Forum Posts Private Message View Blog Entries View Articles Add as Contact

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Posts 1,221 Today 03:04 "Furthermore, some studies have found that smoking pot accelerates the development of schizophrenia in those who are genetically predisposed, but that association took a hit in 2010, when researchers found that accounting for things like gender, lifetime mental health history, and socioeconomic status erased the effect." <- excerpt from article

http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2900481/ <- This study being refered to

((scathe scathe scathe))

I looked into the "erasure" claim made in this portion of the article and found out a few things in the research that make me wonder. There were 4 variables to predict a lifetime history of cannabis use disorders in first-episode subjects (one more than the 3 mentioned in the article): male gender, lower subject socio-economics status, better premorbid childhood social adjustment, and more severe positive symptoms at study entry. I see no need to leave that last one out, other than to give the article some sense of balance.

So, these variables predict whether or not a young adult schizophrenic patient had a lifetime history of cannabis use disorder NOT whether or not they had used cannabis. They used multivariate logarithmic recursion, which I have some untrusting familiarity with. The claim in question is that of the article. The study has some clever things to say about smoking dope... and I have some equally ingenious questions, however, this claim really boils down to the strength of the mathematical recursion model. This plot describes 32% of the variation. This model would certainly give you erroneous results. I would not use it for anything. Last edited by pmoseman; Today at 03:11.

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#3 CLICKHEREx View Profile View Forum Posts Private Message View Blog Entries View Articles

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Posts95Today 14:30 Anyone who has a family history of schizophrenia would be well advised to avoid cannabis use, but if they continue to use, they may well benefit from the following:

"A study from the Orygen Research Centre in Melbourne suggests that omega-3 fatty acids could also help delay or prevent the onset of schizophrenia. The researchers enlisted 81 'high risk' young people aged 13 to 24 who had previously suffered brief hallucinations or delusions and gave half of them capsules of fish oil while the other half received fish-tasting dummy subtitute. One year on, only three percent of those on fish oil had developed schizophrenia compared to 28 percent from those on the substitute, but the result has not yet been published in a peer reviewed journal.[13]"

View: http://en.wikipedia.org/wiki/Fish_oil & http://www.oilofpisces.com/depression.html#depression Check out: http://www.google.com/search?q=niaci...=0&aqi=g1&aql=

A post on natural treatments for psychosis (visual / auditory hallucinations, and / or delusional beliefs) may be found at https://au.answers.yahoo.com/questio...5052114AAO7Lf0

[-RC-]

Yeah, I agree, it is complicated.

http://www.responsiblechoice.com.au/cannabis/cannabis-does-not-cause-psychosis/

[upside]

Great link RC,, paranoia due to prohibition and the implications with being mistreated under an unjust law,, absolutely, I've felt that!.