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theobromos

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Posts posted by theobromos

  1. Posted

    I often do right hand turns here for no apparent reason, no need to ask to be excused.

    I think the UN decided it was a baddie and lots of governments followed suit. Why do they need reasons if it affects the mind? It was definitely being smoked by the time of Woodstock. The UN Convention on Psychotropic Substances mentioned it in 1971.

    http://www.incb.org/e/conv/1971/index.htm

    Argentina, Austria and Britain followed rapidly in 1971. Egypt 1976.

  3. Posted

    DANGER WILL ROBINSON DANGER

    I got access to a university library computer today and found the startling facts from the paper I mention above, Yamamoto, L.T. Gen. Pharmacol. 1999.

    Mitragynine pseudoindoxyl is a potent agonist of mu and delta opioid receptors but of negligible kappa effect. Compared to other opioids it is a hundred times more powerful than mitragynine, 20 times more powerful than morphine and 4 times more powerful than the endogenous opioid DAMGO enkephalin. We are talking sub-milligramme doses here.

    Obviously this has huge implications for mitragynine users. Looking at the structure I would say that mitragynine probably converts easily by air oxidation (and possibly rearrangement with time), certainly more easily than the ibogoids. This means that if you leave powdered mitragyna around it might become 100 times more powerful. As in potentially deadly at your normal dose.

    The safest way to avoid this might be to convert all the mitragynine in your herb before you establish a safe dose :) Or store under a nitrogen atmosphere, very easy to do with a home-made glove box, I expect.

    The authors quote Zarembo JE et al J Pharm Sci (1974) 63: 1407-1414 for the biotransformation of mitragynine to the pseudoindoxyl derivative by a Helminthosporum sp. mould.

  5. Posted

    Yeah, and why didn't Albert Hofmann keep his mouth shut about LSD and psilocybin? Why did Osmond report his results? Then the hoi polloi wouldn't know about them and they wouldn't be illegal. Only a cabal of elite pharmacognosists would have the Philosopher's Stone.

    Everybody has the potential to use these substances wisely if they are given the information.

    ¡Power to the People!

  9. Posted

    Good, bluemeanie, you are managing to work with your doctor. They can find it very difficult to treat people with educations of their own, be patient with them. It is very difficult being a good doctor. I have had problems myself with stupid doctors, yes, I do know.

    Good luck!

  12. Posted

    This might be one of those cases where the leaves at the top of an old tree don't bother with some of the defences they needed when the leaf was within reach of ground-dwelling herbivores. Like the holly which at the top of the tree doesn't have spines on the leaves.

  13. Posted

    We now appear to have the full range of opioid agonists available from non-opium sources:

    Life Sci. 2004 Mar 12;74(17):2143-55.

    Antinociceptive effect of 7-hydroxymitragynine in mice: Discovery of an orally active opioid analgesic from the Thai medicinal herb Mitragyna speciosa.

    Matsumoto K, Horie S, Ishikawa H, Takayama H, Aimi N, Ponglux D, Watanabe K.

    Laboratory of Chemical Pharmacology, Graduate School of Pharmaceutical Sciences, Chiba University, 1-33 Yayoi-cho, Inage, Chiba 263-8522, Japan.

    Mitragynine is an indole alkaloid isolated from the Thai medicinal plant Mitragyna speciosa. We previously reported the morphine-like action of mitragynine and its related compounds in the in vitro assays. In the present study, we investigated the opioid effects of 7-hydroxymitragynine, which is isolated as its novel constituent, on contraction of isolated ileum, binding of the specific ligands to opioid receptors and nociceptive stimuli in mice. In guinea-pig ileum, 7-hydroxymitragynine inhibited electrically induced contraction through the opioid receptors. Receptor-binding assays revealed that 7-hydroxymitragynine has a higher affinity for mu-opioid receptors relative to the other opioid receptors. Administration of 7-hydroxymitragynine (2.5-10 mg/kg, s.c.) induced dose-dependent antinociceptive effects in tail-flick and hot-plate tests in mice. Its effect was more potent than that of morphine in both tests. When orally administered, 7-hydroxymitragynine (5-10 mg/kg) showed potent antinociceptive activities in tail-flick and hot-plate tests. In contrast, only weak antinociception was observed in the case of oral administration of morphine at a dose of 20 mg/kg. It was found that 7-hydroxymitragynine is a novel opioid agonist that is structurally different from the other opioid agonists, and has potent analgesic activity when orally administered.

  15. Posted

    electro, I have been reading up on pseudoindoxyls. I have not come to a conclusion yet but peroxide will only only take it to the first stage of three, and can result in two different pathways of reactions.

    Of course the other intermediates may be active but test at your own risk. Remember to make your notes waterproof and stainproof for the coroner :)

    The best bet looks like recipes for iboga alkaloids: freebase air oxidation in a solvent like chloroform giving the hydroxyindolenine. This is followed by rearrangement to the pseudoindoxyl in hot methanol saturated with hydrogen chloride for one hour. However some are more resistant and need platinum catalysts.

    I have yet to look at yohimbine pseudoindoxyl.

  16. Posted

    The only thing I ever brewed was saki. It blew the top off the demijohn (duhhhh - 10 day fermentations need a bucket not a demijohn don't they?) and I had all the organic brown rice vinegar I could use for quite a while.

    I have read that the yeast is more tolerant if you use pure glucose as the sugar.

  18. Posted

    THC acetate effects, strength and other relevant facts. The "controversy" about strength would be from people who don't understand how to make quality product, grump, grumble. In my first post in the thread.

  19. Posted

    Well, this is in English and available to anyone with academic journal access, the journal being General Pharmacology:

    Yamamoto, L.T., S. Horie, H. Takayama, N. Aimi, S. Sakai, S. Yano, J.J. Shan, P.K.T. Pang, D. Ponglux and K. Watanabe. Opioid receptor agonistic characteristics of mitragynine pseudoindoxyl in comparison with mitragynine derived from Thai medicinal plant Mitragyna speciosa. Gen. Pharmacol. 1999 Jul;33(1): 73--81.

  22. Posted

    Refluxing THC with traces of sulphuric acid in toluene will drive the THC to its least vulnerable isomer (if not to something else cannabinoid) and will probably reduce its psychoactivity appreciably. Certainly some things will form an ester with the acid, like yohimbine does, did the bee describe the resulting product at all?

    THC will acetylate easily I believe but room temperature and mild detergents are preferable for delicate textiles.

    Read this:

    http://www.shaman-australis.com/cgi-bin/ub...t=001257#000020

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