theobromos

Oh fuck, that Peter Houghton I have just been in too much of a hurry lately. Must slow down a little.

UK Home Office considering the possibility of prohibiting use of khat. Plans are not immediate. http://news.bbc.co.uk/2/hi/health/3461995.stm

I gave up smoking after a bout of ear infection that became mild meningitis before the doctor would believe me. Nobody mentions much that a smoker suffers ten times as many infections due to the suppression of their immune system.

Vinegar is almost unable to be a free base solvent. Are you sure glacial acetic is more polar? A lot of leaves are full of phytates and tannates.

I assume they like it as an ornamental, in which case suggesting that you take out those four unsightly long branches in the centre would go down well. Improve the shape and encourage the side branches.

Thanks for saying waterlily, there are psychoactive true lilies (Lilium) as well and we wouldn't be wanting any confusion right? The apple of Aphrodite and the waterlily of the nymphs? What could be better? Except cherry or strawberry wine perhaps, both Venusian fruits. Most people are using the flowers but surely the leaf contains something. Has anyone tried Nymphaea seeds? The embryos of the seeds are the strongest part of Nelumbo but that is different. Port is illegal in Queensland? Wouldn't surprise me.

Thanks, Fractalhead. Hope I can work out a better method than lead salts and sodding methoxide. Idplugg, the salts are probably much more stable than the free base so it would be difficult to do in a water solution.

I might scan it and use it for my little picture. I am delighted with it and the occurrences of the days previous of which I will be reminded. **************************************************************** I have always relied on the serendipity of strangeness.

I have just had my first tattoo and would like to know if there are better things than flammazine ointment to rub on it. I don't mind for the first few days but is there any other more natural procedure for later? I have a large and healthy aloe vera plant, for example. Also what high sun protection factors are pure vegetable? Carrot in cocoa butter? If he had told me it was prone to fade in sunlight beforehand I wouldn't have had it on my wrist.

A flower of the Lesser Periwinkle, Vinca minor. Thanks for the suggestions, I usually heal fast so I hope it will be over soon. I just threw away a huge bunch of Hypericum that I never got round to making an oil from.

I am sure friendly will have those Chinese herbs for the formula, probably the dried leeches as well. I would expect his three months course would be cheaper and excellent quality. Also available as extracts.

I illegally copy the Daily Telegraph obituary of Dr Osmond, who died on February the sixth, below. But first a few words on what he meant to me though I never met him. I was born in 1963. I grew up in a small town in a rural part of England. The atmosphere was conservative but the media reported such strange things happening in the world. I knew from the age of 9 that I wanted to try out some of these interesting plants that affected the mind. That was when I read an article in an encyclopaedia for children that certain "Arab tribesmen" who disliked alcohol would smoke a plant that made them happy and silly. I had seen adults drunk (and was given some sloe gin by my granny when I was 6) so I knew that though it made them silly it did not seem to make them happy. It seemed to me to be logical that the best study for humans is the human mind and that the effects of chemicals on that mind would help to elucidate much of its functioning. So I started looking for plants that would help me understand or explore these territories. At the age of sixteen I finally, to my surprise, found a local source of this exotic "cannabis". Further enquiries led to the fascinating Psilocybe semilanceata. I was very aware that I was unusual not just among straights but among the druggies as well. I had an obsessive desire to know. Soon I met others with similar interests. But for several years I was alone in my world. My local library had many good books. And some strange ones including a Spanish version of a T. Lobsang Rampa and the Teachings of Don Juan. Neither in the Fiction section, curiously. But for me the book I looked at every time I visited was "Psychedelics" by H. Osmond and B. S. Aaronson, just to remind me that there were researchers out there looking scientifically and philosophically at the psychedelics and that there might well be a place for me in this world. I am not sure it would be too much to say that Dr Osmond saved me from suicide. He appeared to be a happy man as well as enthusiastic. He was a good communicator, my favourite quotes from the obituary are: "I believe," he wrote, "that psychedelics provide a chance, perhaps only a slender one, for homo faber, the cunning, ruthless, foolhardy, pleasure-greedy toolmaker, to merge into that other creature whose presence we have so rashly presumed, homo sapiens, the wise, the understanding, the compassionate, in whose fourfold vision art, politics, science and religion are one." "My experiences with these substances," he added, "have been the most strange, most awesome, and among the most beautiful things in a varied and fortunate life." Who could disagree with "To fathom hell or soar angelic/Just take a pinch of psychedelic.". I am afraid the rebranding of psychedelics as enthogens has always left me cold (or hotly angry). You don't change the public's view of something by changing the name so they don't know what you are talking about. I don't remember ever laughing while reading an obituary before. Though I cried as well. If you are faring still, fare thee well, Dr Osmond. **************************************************************** Dr Humphry Osmond (Filed: 16/02/2004) Dr Humphry Osmond, the psychiatrist who has died aged 86, coined the term "psychedelic" to describe the mind-altering substances LSD and mescalin, and introduced Aldous Huxley to these drugs; in 1953 he administered 400 mg of mescalin to Huxley, an episode described in the novelist's cult book The Doors of Perception (1954). Osmond had become interested in d-lysergic acid diethylamide (LSD) after reading the Swiss chemist Albert Hoffman's description of the psychological and behavioural effects of the drug. Having noticed that LSD seemed to mimic the symptoms of early schizophrenia, Osmond had been investigating its use in the treatment of mental illness and alchoholism. In 1952 he shocked the medical world by drawing attention to the structural similarity between mescalin and adrenaline molecules, implying that schizophrenia might be a form of self-intoxication caused by the body mistakenly producing its own hallucinogenic compounds. He suggested, moreover, that mescalin enabled a normal person to see the world through the eyes of a schizophrenic and should be used as a training tool for members of the medical profession. When Huxley - whose novel Brave New World (1931) described a totalitarian society in which the population is controlled by drugs - read Osmond's report, he decided to offer himself as a guinea pig. At first Osmond was apprehensive; he did not, he later wrote, "relish the possibility, however remote, of finding a small but discreditable niche in literary history as the man who drove Aldous Huxley mad". He was relieved, therefore, when, as the drug took effect, Huxley exclaimed: "How absolutely incredible!" It took Huxley 70 pages to relate, in The Doors of Perception, what happened on that first "trip". An hour and a half into the experience he described staring at a bunch of flowers: "I was seeing what Adam had seen on the morning of his creation - the miracle, moment by moment, of naked existence." In fact, far from undergoing "imitation psychosis", Huxley had a mystical experience, and predicted that a religious revival would come about "as the result of biochemical discoveries that will make it possible for large numbers of men and women to achieve a radical self-transcendence and a deeper understanding of the nature of things". Osmond and Huxley remained close friends after their experiment and corresponded for many years. During their search for a name to describe the hallucinogenic drugs, Huxley proposed the word "phanerothyme", derived from roots relating to "spirit" or "soul". He wrote to Osmond, "To make this trivial world sublime/Take half a gramme of phanerothyme." Osmond replied: "To fathom hell or soar angelic/Just take a pinch of psychedelic." Psychedelic, from the Greek for mind ("psyche") and the verb "delein" (to manifest), means "mind-manifesting". In 1957 Osmond addressed a meeting of the New York Adademy of Sciences using the term. Hallucinogenic drugs, he argued, did much more than mimic psychosis, and thus needed a name that included the "concepts of enriching the mind and enlarging the vision". During the 1950s and 1960s, psychedelics were used, with some success, in the treatment of a variety of psychiatric disorders. But after their use (and abuse) by the hippy generation, they were officially prohibited in 1966, and by 1970 had been classified as illegal. For Osmond - who, far from being a hippy, was a respectable research scientist - the need to protect society had the effect of limiting progress. "I believe," he wrote, "that psychedelics provide a chance, perhaps only a slender one, for homo faber, the cunning, ruthless, foolhardy, pleasure-greedy toolmaker, to merge into that other creature whose presence we have so rashly presumed, homo sapiens, the wise, the understanding, the compassionate, in whose fourfold vision art, politics, science and religion are one." "My experiences with these substances," he added, "have been the most strange, most awesome, and among the most beautiful things in a varied and fortunate life." Humphry Osmond was born on July 1 1917 in Surrey and educated at Haileybury. After leaving school he intended to become a banker, but ended up working for an architect, an experience that was to have a lasting effect. After attending Guy's Hospital Medical School, Osmond served as a surgeon-lieutenant in the Navy, where he trained to become a ship's psychiatrist. Following demobilisation, Osmond did a formal residency in psychiatry at St George's Hospital, Tooting, where he met and married a nurse, Jane Roffey. He began to take an interest in hallucinogenic drugs and their use in the treatment of psychiatric illness. In 1951, after his ideas met with little enthusiasm in the Freudian-dominated British mental health establishments, Osmond and his wife emigrated to Saskatchewan, Canada. There he set about applying his considerable energy and creativity, overhauling the Weyburn Mental Hospital. With his colleague, Abram Hoffer, he investigated treatments for mental illness based on dietary changes and large doses of vitamins, and discovered that niacin could aid the treatment of schizophrenia. Osmond's interest in psychedelics was not confined to the treatment of schizophrenia; under his supervision, architects took LSD and spent time on hospital wards in an attempt to understand what would be the most appropriate environment for a mental patient. Having noted that some alcoholics gave up drink after they suffered from delirium tremens, he gave almost 1,000 alcoholics a high-dose LSD treatment and achieved a 50 per cent recovery rate - far higher than other forms of therapy. He was also involved in a number of LSD experiments with high profile subjects, such as "authors, artists, a junior cabinet minister, scientists, a hero, philosophers and businessmen". Most of them, he said, "find the experience valuable, some find it frightening, and many say that it is uniquely lovely". After leaving Saskatchewan, he became director of the Bureau of Research in Neurology and Psychiatry at Princeton, going on to join the University of Alabama Medical School. His publications include The Chemical Basis of Clinical Psychiatry (with A Hoffer), Psychedelics (with B S Aaronson), and Models of Madness (with M Siegler). Humphry Osmond, who died on February 6, is survived by his wife, two daughters and a son.

Just what Dr Osmond was recommending... Oh, no, the article appears to be about doctors using internet technology. http://www.nature.com/nsu/040216/040216-4.html

"most anti-drug as well as 'non-drug' people would view it as..." These people think euphoria is evil and need more education than an article in the Guardian to help them. For designer drugs, SirLSD, that might have been the original meaning. However, times have changed and governments are a bit more on the ball. Surely now a designer drug is any synthetic analogue of a traditional drug from natural sources. The phrase used here, "Designer Class A Drugs" does not mean that they are primo trips but scheduled as a Class A Drug under the Misuse of Drugs Act.

Yesterday morning I got on a bus, deciding at the last minute to go in the morning and move house that day. A man on the bus had a copy of the Telegraph, obviously having flown in from Britain that day and I asked if anything had happened in the old country that I should know of. He said I should read the paper. Serendipity.

Fascinating, the xanthines are very important in fungal metabolism. Olé su polla, whoever thought of this one. At the very least it is a fast, easily assimilable nitrogen source. I believe the sclerotia called Philosopher's Stones are more relaxed because of their content of adenosine which acts in the opposite sense as caffeine.

If someone goes to the bother of using chloroform or dry alcohol for an extraction of alkaloids of any type they would be silly not to use ammonia first as none of the salts would be very soluble in the former and not VERY soluble in the latter. The question was "kratom prep?". Pedantic, I?

What is all the fuss about? It is the least sexy thing I have seen on earth. I assume leather or rubber fetishists liked it, but I prefer my pagan cults in natural vegetable fibres.

For the acetate experience see: http://www.shaman-australis.com/cgi-bin/ub...t=001257#000020 Wouldn't the glycosylation and phosphorylated THCs be rather horribly detergent-like? As would the alkaloid aminomethylTHC? You like cappucino? You might as well dissolve it in the milk. Or preferably hempseed milk.

Auxin, 5MeODMT is a relatively new drug in its pure state, no? Wouldn't want to confuse whole plants and crude extracts with pure chemicals now, would we?

If you think this is an antidrugs article then I, too, must be antidrugs. Though I would say that I am cautious and informative.

Oh, yes, that would appear to be the case.

OK friendly, I won't do it. Though I have a good idea that I could Just a little amiable prod, Torsten. Always try to be good, but the oxygen density down here is getting to me. Ammonia to get rid of those pesky organic acids, certainly the phytates and tannates won't be soluble in much short of aqua regia. Then chloroform or alcohol is the usual way to get these out, no? And what could be a more common solvent than vinegar (distilled malt vinegar is recommended for many extracts). The cheapest and easiest of the ibogaine extractions for example. Are there any pseudoindoxyls of this type mentioned in the Merck now?

What does a little raw garlic do to you?

Bugsy might have been a cousin of mine but that side of the family ain't blabbin'. [ 18. February 2004, 05:31: Message edited by: theobromos ]