Why Do Mind-Altering Drugs Make People Feel Better? Scientists want to redesign psychedelics so that they don’t induce a trip—but they still improve mental health.

[Alchemica]

Why Do Mind-Altering Drugs Make People Feel Better?
Scientists want to redesign psychedelics so that they don’t induce a trip—but they still improve mental health.

Why Do Mind-Altering Drugs Make People Feel Better? | The New Yorker

 

I've done a pdf for those who want to read but don't want to sign up

Why Do Mind-Altering Drugs Make People Feel Better.pdf

[saguaro]

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Edited March 15 by saguaro

[saguaro]

Just now, saguaro said:

My guess is that there will never be anything which has a comparable effect on mental health and neuroplasticity that something like psilocybin does. I suspect the novelty and perspective altering of the psychoactive effect is partly responsibility for these effects.

 

Certainly nothing down this path will have a comparable safety and side effect profile.

 

 

[ehteam]

Not sure if breaking rules, but guess  I`ll find out and maybe it`s just happened to me. About 20 years ago I had a severe stroke, upon returning home I found a 750g jar of honey with about 50 gold tops in it, they use to grow in a backyard of where I was living at the time and had been in the cupboard for about 3 years. Over a day I ate all the honey, not the mushrooms, expecting to trip. The trip never happened and was a bit disappointed, but realized later that the depression I had, left me, this is not a recipe, but how things worked for me. Upon reading the subject, mind altering drugs, without a trip, I thought I`d throw this in as a reply.

[wachumacallit]

I think they're also working on a surgical modification to enable sex without pleasure ... oh wait ... yeah, that's a very old (Stone Age) technique.

 

Among TESCREAList fantasies, I've observed a strategic need for the invention of Soma -- something to keep those who will be left behind satisfied with their miserable lot in life. A "psychedelic" stripped of mind-manifesting potential (doublespeak if ever I heard such) would fit the bill admirably--and presumably reserve "true" psychedelic experience for the star-bound elite.

 

I was attracted to San Pedro, initially, because of its visionary potential -- but learned along the way that sub-threshold doses have enormous psycho-therapeutic potential.  

 

Presumably micro-dosing would fall into a similar class of sub-visionary psychedelic therapy? But in that case, where's the lucrative payoff for researchers, in terms of novel molecules and patentable drugs? 

[Breizh]

21 hours ago, wachumacallit said:

I was attracted to San Pedro, initially, because of its visionary potential -- but learned along the way that sub-threshold doses have enormous psycho-therapeutic potential.  

 

The broad array of alkaloids is fascinating. Especially the tetrahydroisoquinolines. Mescaline is also quite unique. It appears to act as a mildly active prodrug. The active metabolites are uncharacterised (unknown) due to insufficient academic investigation. Considering that most of the dose is excreted unchanged (or as the N-acetyl) then the potency of the active metabolites must be substantially greater than mescaline. I estimate similar to the 2C-× class.

 

This prodrug dynamic can be catalysed (made more efficient) using appropriate potentiation methods (ALDHI) and dietary conditions. Theoretically, in ideal conditions, this would make a dose of 25-100mg active and strong. In contrast, there are some people who require 1g to only get regular effects.

[-RC-]

 It's because they prove you wrong in an incontrovertible way.