Alchemica Posted September 27 Share Posted September 27 I've been interested in this plant as a potential pro-cognitive but wonder if it could also have merits in augmenting plant medicines. Convolvulus plauricalis (Shankpushpi) has nootropic, neuroprotective, anti-depressant, anti-stress, anti-inflammatory, anti-oxidant, anti-convulsant, anxiolytic, analgesic, spasmolytic, aphrodisiac, sedative, anti-Alzheimer's, and anti-Parkinson’s activity. The most notable constituents are tropane alkaloids. Only convolamine has been identified, but other alkaloids (convoline, convolidine, convolvine, confoline, convosine, etc) found in other species from this family are probably present. Convolamine is a potent positive modulator of the sigma-1 receptor [1] Scopoletin, kampferol and β-sitosterol were also found in significant amounts While I'm interested in the neuroprotective, pro-cognitive effects, the action of sigma-1 positive modulation makes me ponder if it may be an effective novel admixture - σ1R modulation seems to have a useful therapeutic augmentation effect of serotonergics etc and it's often used as a polyherbal remedy. [1] Crouzier L, Meunier J, Carles A, Morilleau A, Vrigneau C, Schmitt M, Bourguignon JJ, Delprat B, Maurice T. Convolamine, a tropane alkaloid extracted from Convolvulus plauricalis, is a potent sigma-1 receptor-positive modulator with cognitive and neuroprotective properties. Phytother Res. 2024 Feb;38(2):694-712. https://doi.org/10.1002/ptr.8068. [2] Balkrishna A, Thakur P, Varshney A. Phytochemical Profile, Pharmacological Attributes and Medicinal Properties of Convolvulus prostratus - A Cognitive Enhancer Herb for the Management of Neurodegenerative Etiologies. Front Pharmacol. 2020 Mar 3;11:171. https://doi.org/10.3389%2Ffphar.2020.00171 Quote Link to comment Share on other sites More sharing options...
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