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Alternative Therapy of Psychosis: Potential Phytochemicals and Drug Targets in the Management of Schizophrenia


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Found this to be a good review. Not suggesting self-medication using plants as a standalone to replace conventional pharmacotherapy but particularly think it may have some merits as adjunctive treatment, particularly if one sticks with more benign phytochemicals in line with more dietary-type modifications etc

 

Alternative Therapy of Psychosis: Potential Phytochemicals and Drug Targets in the Management of Schizophrenia

https://doi.org/10.3389/fphar.2022.895668

 

Anti-schizophrenic drugs have variable efficacy in different patients, with often poor efficacy and sometimes with debilitating side-effects. There is a great need of more efficacious and safer remedies. Phytochemicals offer potential and diverse alternatives to allopathic anti schizophrenic medicines due to their wide array of biological activities such as anti-inflammatory activity, anti-oxidant potential, affecting neurotransmission, and modulating cell signaling pathways

 

Possible factors?

- genetic and environmental factors, prenatal infections
- neurochemical factors (dopamine, gamma-aminobutyric acid (GABA) and glutamate, serotonin and noradrenaline
- interplay of neuro inflammation, oxidative stress, cell signaling pathways and abnormal immune system activation

 

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Phytochemicals playing a beneficial role?
- Phytochemicals showing efficacy against schizophrenia belong to different phytochemical classes such as alkaloids, tannins, glycosides, phenolic acids, flavonoids, terpenes, terpenoids and essential oils.

 

 

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I have schizophrenia and the medications I need to take to maintain some level of functioning are the worst! The side effects are horrible.

 

Funnily enough I also have found that NMDA antagonists have some sort of therapeutic effect on me.

 

I've tried a lot of things to help but I have also found CBD with a low level of THC was helpful for me. 

 

The most important part of my recovery has been a focus on inner work through meditation type practices.

 

 

 

 

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