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Phytochemical and biological evaluation of Salvia apiana (White Sage).

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Some extremely intriguing and promising results on the pharmacological evaluation of Salvia apiana.  I am very eager to conduct an ethanolic extract on some white sage leaves as soon as I can acquire enough material in order to bioassay the extract and take note of any potential psychoactivity.  As from what this data postulates, it may very well be an effective analgesic and anxiolytic compound. :lol:

 

Abstract:

"Salvia apiana (white sage, Lamiaceae family) plant is native to southern California and parts of Mexico. Some Native American tribes local to this region consider S. apiana to be sacred and burn the leaves as incense for purification ceremonies. The plant has been used to treat sore throats, coughs, chest colds, upper respiratory infections and poison oak rashes. The aqueous ethanolic extract of S. apiana showed moderate CB1 activity (58.3% displacement). Chromatographic purification of the ethanolic extract on silica gel column led to isolation of nine compounds: rosmadial (I), carnosol (II), 16-hydroxycarnosol (III), sageone (IV), cirsimaritin (V), salvigenin (VI), oleanolic acid (VII), 3β,28-dihydroxy-urs-12-ene (VIII), and ursolic acid (IX). The structures of the isolated compounds were determined by their 1D, 2D NMR and MS spectral data. All the fractions and isolated compounds were tested for cannabinoid and opioid receptor binding."

 

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5505801/

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Interesting stuff. Surprised that this research hasn't already been done based on Sage's long history of use.

 

Off topic but is there a place where one can get updates on these kind of new Ethnobotanical studies?

Online ethnobotany journals or something?

 

 

Edited by squidgygoanna
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Good question. I'm sure there would be a number of online Ethnobotanical/pharmacology journals, so I'll see what I can find and post some links in here if I source any decent ones! :)

 

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Did you ever get far on this @LikeAshesWeFade?

 

While I think you can do a lot medicinally with Salvia officinalis and that should be more widely appreciated medicinally, showing potent modulation of CNS receptors [1], AChE inhibition etc with cognitive and mood-enhancing efficacy [2], I'm interested if the White Sage is even more useful for cognition and mood - as you've highlighted, as far as we know, the biological properties extracts from S. apiana aerial parts were limited to the screen of the cannabinoid or opioid receptors activity (It showed moderate CB1 activity and some constituents opioid activity) [3] S. apiana is particularly rich in phenolic terpenes.

 

[1] https://www.ncbi.nlm.nih.gov/pubmed/31196061
[2] https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5318325/
[3] https://www.ncbi.nlm.nih.gov/pubmed/28025900


Full thesis on the topic including extraction etc : http://thesis.honors.olemiss.edu/622/1/Taylor Hayes Thesis.pdf

 

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Hey dude, nah I've not done much more digging into S. apiana as of yet but will definitely check out that extraction method and possibly do a little bioassay of the crude extract to see what effects are noticed, if any.

 

Given the results of that study in comparison to the control opioid and cannabinoid agonist drugs they used, it definitely sounds very promising and may very well have some level of psychoactivity!  :lol:

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