Lagochilus inebrians (intoxicating mint):
The diterpene-alcohol Lagochiline was found to be an antagonist at metabotropic glutamate receptors:
http://stimuluswatch...hoactive-plants
this action was also observed at Lithium and nootropics
the mGlu-5- receptor was shown to play a role in cocaine addiction.
mGlu-Rs also play a role in the sedative action of alcohol and some ligands have analgesic action.
Lactuca virosa (letuce):
Inhibits NEP enkephalinase and therefore enhances the endorphine- levels which leads to analgesic and anti-opiate-withdrawal effects. (FUNKE et al 2002):
http://www.wildlettucehq.com/ (halfway through on the site you can see the study on the NEP- inhibition)
Additional it works as a Adenosine receptor agonist and acetylcholinesterase inhibitor (nootropic).