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The Corroboree

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About Change

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    amateur plant surgeon

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    Hunter Valley

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    The Pond

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  1. Change

    covid 19 vaccination

    I feel for ya Halycon, this must be a really difficult time for families especially with members in vulnerable age groups or with pre-existing medical complications. I hope you can see im not attacking you personally, im attacking the media, and the polarity of this left versus right debate, because it’s distracting us all from making progress in their constant quest of political point scoring. We need to reject the system dictating the norms and replace it with an updated model designed to serve us. It blows my mind reading some people commentary of the various state government responses. As if it demonstrates their political team are doing a superior job compared to the others. Its both confusing and sad to see people celebrating the miss management of the pandemic because it was done by their political opposition, and they would prefer to point the finger rather than have the problem solved. This is all the left versus right debate is, pointing the finger rather the offering realistic viable solutions. Politicians are not problems solvers, therefore expecting them to solve problems is redundant Clearly both political teams are robbing us blind, and F***ing up the response, we are 2.5 years into this pandemic, and we still don’t have a clear solution in sight. All we have got, is some business leaders talking about what they are going to do to minimise the effect upon the economy. Meanwhile the inequality continues to rise…. https://www.abc.net.au/news/2021-01-25/covid-19-pandemic-exacerbating-wealth-inequality/13089128 Then long covid only complicating this issue further https://www.nature.com/articles/s41587-021-00984-7?fbclid=IwAR0aevXfZ5yfIFrlQl7jWveR7XaVUym6Prr4W57BXfd1xoVNKQY04-drC94 I’ve been worrying about this for a while, now take it with a grain of salt because this pre-print is yet to complete the peer review process, however it is suggesting corona virus can insert itself into your genome, which explains how “long covid” may function. If this is true, it really should have been taken into consideration well before we started designing vaccines and medications to control this novel viral infection and would be important to consider as it will most certainly affect results generated by PCR testing. https://www.sciencemag.org/news/2020/12/coronavirus-may-sometimes-slip-its-genetic-material-human-chromosomes-what-does-mean https://www.biorxiv.org/content/10.1101/2020.12.12.422516v1.full.pdf
  2. Change

    covid 19 vaccination

    Morning Halcyon Daze, Im sorry if you felt attacked by my comments, that was not my intention. I just wanted to point out these opinion pieces are bias towards their team. For example, this last opinion piece video you have posted featuring “Dr Gottlieb” from the board of directors of Pfizer is dripping with bias. Sure, Dr Gottlieb is a doctor, but all he does in that video is chat about his opinions and states a few unreferenced facts to support his claims. Real scientist present data (Results), discuss the methods used to collect the data (Materials and Methods) and discuss the interpretation of the data and the possible implications of the results being generated (Discussion). Then they publish it in journal, scientist don’t need the media to report their finding, media coverage doesn’t do anything for a scientist career, its all about publications and their impact factor. On the other hand, if your on the board of directors for a pharmaceutical company, you need the media to put out the messages that you want the public to hear, which is why Dr Gottlieb has time for media interviews, rather then being busy in the laboratory working on ground breaking medical research. So, in regard to Buttstacks comments, yes scientist can be purchased just like politicians. But it simple to pick which scientist are working with an agenda rather then working towards generating independent data for interpretation, all you need to do is look at where their funding is coming from. Are they on a salary from a multinational pharmaceutical company or are they receiving grants from the “Australian Research Council” or similar independent research organisations. Earlier in this thread I shared some opinions about how id like to see small RNA technologies being researched as treatments for covid infection, if your interested here is a summary of transcription and translation inhibitors being developed as cancer treatments, because RNA based viruses rely upon translation mechanisms to express their proteins, we could be using similar mechanisms to prevent serious covid infections from occurring. https://www.frontiersin.org/articles/10.3389/fchem.2020.00276/full And here is summary of Clinical Research thats’ been investigating microRNA technology as potential therapeutic agents https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6532434/ “Reject the system dictating the norms” “Time for Change”
  3. Change

    covid 19 vaccination

    With all due respect, opinion pieces like “Anti-vaxxer nurse dies of covid” hold relatively equal value to opinion pieces titled “Women dies from blood clot shortly after being vaccinated”. Its cherry-picking specific data points that support your team. The Left and the Right have wasted enough of our time, its time to bring forth a new political paradigm, the scientific revolution. When we decided to elect officials with science backgrounds rather than commerce backgrounds things will change. Until then we are stuck in a cycle of repetition where the wealthy elites continue to reap the benefits of having commerce leaders controlling policy development in their favour. Time for Change
  4. Change

    covid 19 vaccination

    Morning Cubisum, Thanks for responding, I appreciate you taking the time to share your thoughts, you’re a clever human and ive always enjoyed reading your posts I look forward to continuing the chat another morning when ive had more than 3 hours sleep and ill be sure to check out Nick Brown. But for now its time to pump some tunes and keep the good vibes rolling Love to all PS, did anyone notice the size of the Diamond earings that "Gladys Berejiklian" wore during the press conference yesterday? holy moly, those were some big rocks
  5. Change

    covid 19 vaccination

    Morning Cubisum Thanks for your link, I had a look over it, and it appears to be referencing a different study from Benha University in Egypt. The link I provided is a meta-analysis, looking at “Twenty-four randomized controlled trials involving 3406 participants” and to my currently knowledge it has not been discredited like the single paper that’s references in the “Guardian media” article you provided. So once again, the media and politicians are cheery picking studies to discredit each other’s studies in this stupid political football game that’s the mass media keeps brain washing the public with. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8248252/ This is precisely the point im trying to make, media outlets have become so tied up in this ridiculous political battle, that it becomes difficult for the regular citizen to look at the evidence from an independent perspective. While we keep debating this from the perspective of left versus right, we are just letting political morons control the response. We are 2.5 years into the pandemic at some point people will wake up and start blaming politicians miss management and lack of scientific integrity, rather then blaming the left or the right. Imagine if scientist received funding = to political salaries and donations, progress might actually be made.
  6. Change

    covid 19 vaccination

    This is a perfect example, of why politicising issues brings us further away from the truth. So many left wingers and right wingers who have zero scientific understanding, drew conclusions on this issue, based upon what political team they were on. Then because they spent their time researching politics rather than science, they would discredit each other’s opinions arguing for their own bias, whether it be the lab leak hypothesis, or Zoonotic transfer from Bat to Pangolin to Human. https://www.abc.net.au/news/2021-07-16/who-urges-china-to-share-more-information-about-covid-source/100297904 The political debate around this issue got so noisy, that it drowned out the conversations being had by evolutionary biologist that were presenting sequence data to confirm or deny these hypothesis’s. Therefore, the public was distracted by the left versus right debate, while the opinions of people who have dedicating there lives to increasing scientific understanding went unnoticed.
  7. ^^ Your a hindu goddess its eazy to get attached to your beautiful eyes Toby
  8. Change

    covid 19 vaccination

    Morning Sayn and RC Lets keep politics out of this, there isn’t any point discussing agendas of the right and left wings of politics. That’s all a distraction designed to divide us into teams that will forever be in conflict. We should be debating science, presenting data and discussing the interpretations of the data. We may all be pawns and we may all know nothing, but it only took one Jesus to change the world, and we hold the same potential inside our souls.
  9. Change

    covid 19 vaccination

    Morning Cubisum, Im confused about what the point of things are too…Is the point of the vaccines to prevent transmission via herd immunity or is the point of the vaccine to prevent serious illness requiring hospitalization. My confusion about these vaccines is mostly sparked via the WHO recommendations don’t seem to be lining up with Australian health authorities. I agree that we want to be reducing the burden upon the health care system, and from what I’m reading about Ivermectin, it seems to be effective as both a preventative and a treatment, therefore dosing people in high risk areas would reduce the strain on the healthcare system by preventing infections from occurring at rates similar to what is required to achieve herd immunity. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8248252/ And i totally agree with the investing in hospitials comment, its extremely disapointing that rather then investing in Australian healthcare and medical research we just keep outsourcing the funding to multinational pharmaceutical companies. This is likely due our leadships being more concerned about funding big bussiness than about supporting Australian scientist and their research. idunno why they cant seem to get their head around funding Australia science would allow for a science Boom in australia, sorta like the mining Boom. I probably boils down having dinasaurs controling most of societies investment, if you got wealthy with a concept as simple as digging coal out of the ground, its unlikely your going to see the value of science research.
  10. Change

    covid 19 vaccination

    How efficacious is the vaccine? The AZD1222 vaccine against COVID-19 has an efficacy of 63.09% against symptomatic SARS-CoV-2 infection. https://www.who.int/news-room/feature-stories/detail/the-oxford-astrazeneca-covid-19-vaccine-what-you-need-to-know Are there better options avaliable? Research says yes, The WHO says no... Conclusions: Moderate-certainty evidence finds that large reductions in COVID-19 deaths are possible using ivermectin. Using ivermectin early in the clinical course may reduce numbers progressing to severe disease. The apparent safety and low cost suggest that ivermectin is likely to have a significant impact on the SARS-CoV-2 pandemic globally. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8248252/ However, The WHO has a different perspective The current evidence on the use of ivermectin to treat COVID-19 patients is inconclusive. Until more data is available, WHO recommends that the drug only be used within clinical trials. https://www.who.int/news-room/feature-stories/detail/who-advises-that-ivermectin-only-be-used-to-treat-covid-19-within-clinical-trials Why clinical trials are essential to produce safe and effective medicines, a lesson from the past. https://helix.northwestern.edu/article/thalidomide-tragedy-lessons-drug-safety-and-regulation
  11. Change

    Is herd immunity possible?

    Yeah its rather bizzar that our political leadership are setting these 80% vaccination targets which will allow for life to return to normal, before the worlds leading scientific publication can confirm herd immunity is a viable goal. I guess its reflects the fact that our elected leaders are qualified in the feilds of law and commerce rather then science.
  12. Change

    covid 19 vaccination

    Morning SaYn, Glad to see someones interested in Small RNA technologies Here are some diagrams explaining the mechanisum of action of miRNA (micro RNA) and siRNA (small interfering RNA). Its interesting to note, small RNAs were first discovered in plants, and then later found in animals. Small RNAs play critical roles in regulating gene expression via their ability to modulate gene expression at various levels of transciption (DNA > RNA) and translation (RNA > Protein). Interesting Small RNA research has taken off in the feild of cancer treatments, this is because Small RNAs regulate gene expression via their ability to shut down expression in various ways, allowing for celluar division to occur in a highly controlled manner. Therefore mutations to areas of the genome encoding small RNAs can lead to unregulated cellular division, which ultimately progresses into cancerous tumors. The future for Cancer treatments is personalized genomic medicine, take an extract from the tumor, sequence it, find out what small RNAs are required to shut down the expression of the tumor, design them just like you would primers for a PCR reaction, then inject them directly into the tumor in order to shut down the unrelated gene expression of the tumor and bring back regulated cellular division. These same principles could be used to shut down the expression of sars-cov-2 which would prevent the virus from being able to transcribe and translate its genome into fuctional proteins. Origins and Mechanisms of miRNAs and siRNAs - https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2675692/ Plant and animal microRNAs: similarities and differences - https://sci-hub.se/10.1007/s10142-005-0145-2 MicroRNA: a small molecule with a big biological impact - https://sci-hub.se/10.2174/2211536611201010001
  13. Change

    Is herd immunity possible?

    Is herd immunity possible? seems like an important question to answer.... Five reasons why COVID herd immunity is probably impossible https://www.nature.com/articles/d41586-021-00728-2
  14. Change

    covid 19 vaccination

    Glad to see someone else mention treatment options. Hopefully it wont be to much longer before RNA silencing technology becomes mainstream discussion. No disrespect to Louis Pasteur, but i think its time we used advanced technology that was developed more recently than the 1880s.... https://www.frontiersin.org/articles/10.3389/fphar.2021.616993/full FIGURE 5. RNA interference (miRNAs and siRNAs) biogenesis and function. The miRNAs first transcribed from the nucleus genome as pri-miRNA. Then pri-miRNA cleavage with Drosha and DGCR and converted to pre-miRNA. Then, RanGTP and exportin 5 cause the pre miRNA to be transported from the nucleus to the cytoplasm and cleavage by Dicer and TRBP. Ultimately, after entering the RISC complex, mature miRNA can be attached to the target mRNA and perform their function by destroying mRNA or inhibiting the translation. When inserting into the cell, synthetic siRNAs are cleaved by Dicer in the cytoplasm. This dsRNA enters RISC, and if cold finds the target mRNA, the mRNA is cleaved by the RISC and Ago2.
  15. Change

    covid 19 vaccination

    Personally, I’m really disappointed by how many people are getting their information from the opinions of self-proclaimed scientific experts that are just repeating things they have read without holding relevant qualifications within the field required to understanding this sort of information. It truly baffles me that the general public’s debate, is focused around scientific believers versus anti-vaxers, as if all scientist have drawn the same conclusions and are in complete agreement with each other. It is incredibly disheartening that rather than supporting Australia researchers with novel ideas to develop covid treatments, we have signed up to international pharmaceutical corporations promises of a safe and effective vaccine well before research has demonstrated it to be just that. Meanwhile effective treatment methods aren’t even on the general public’s radar. At this point in time most people seem confused about what mRNA is, so how can they be expected to understand what miRNA’s and siRNA’s is and why using them as a treatment is potentially vastly superior to the development of an effective vaccine. https://www.abc.net.au/news/2021-05-17/queensland-coronavirus-antiviral-treatment-covid-19/100144370 https://www.frontiersin.org/articles/10.3389/fgene.2019.00478/full https://link.springer.com/article/10.1007/s40265-021-01474-5 It would be interesting to investigate the role influenza vaccines have played upon the evolutionary pathways of the influenza virus, and it seems pertinent to have a full understanding of this before we jump into large scale deployment of covid vaccines which may very well end up having similar consequences, if it is demonstrated that vaccinations programs have influenced influenzas evolutionary drift.
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