Not positive what the rules are regarding discussing effects or the specific use of plants but.. When you find an active cutting there is no doubt of its efficacy. I've gotten a couple other people to bio-assay my clone (1 leaf quidded) before heading to sleep. Without being prompted their responses the next day were along the lines of, "you have got to be kidding me." Yes one leaf not grams of dried material. No doubt there are plenty of bitter, astringent almost menthol tasting alkaloids in this clone. Might as well mention that Calea zacatechichi is a synonym for Calea ternifolia. C. ternifolia is used prior in literature. If you have the the ubiquitous branching triangular shaped leaf clone no its probably not going to do anything as it is shown to most likely not even be the correct species.