Alchemica

With any bridgesii I've encountered so far, de-spining, skinning (that is peeling it off, keep the green margin), slicing and oven drying the cactus seems to be the best way to go (...powder it and gulp down with water later). Assume up to 3% dry weight mescaline for Eileen... ~10g dry should get you to a visual space. More if you want to go furthur.

If you get desperate: http://www.pharmacyonline.com.au/empty-gel...ize-p-8690.html I'd suggest that your FOAF buy some vitamin c and make a delicious tea instead...

http://www.ncbi.nlm.nih.gov/pubmed/8721213 I'd also expect it to have some 5-HT2 affinity like THH. 2-Me-THBC might be a product formed during analysis of any DMT containing plant if DCM was used as an extraction solvent: http://cat.inist.fr/?aModele=afficheN&cpsidt=20419602 Agreed. Also agreed! For some, the combination seems to be much like shrooms.

Hey all, Firstly I'd like to thank everyone for their support over the last year - things have been very strange to say the least and I appreciate the help and support from you all. I think I can say that my mind-space has finally started to stabilise but I constantly feel guilty for whatever unhonoured trades or giveaways were made when things were bad. I was in a very strange place for some time and feel very uncomfortable about not having delivered things I promised... so... I'd like to redeem myself. I know I promised a CD while I was extremely out of it and fortunately that concept died with the mania... let me know holymountain and we'll sort out something else if you like (for real this time). ...and Sassy, I know I didn't come through with my promise but if you are chasing a cacti cut or something just ask and I'll make sure it happens. Did I forget anyone? Once again, sorry and thank you for all your support.

Interesting. Would be good to see some solid research into the hallucinogenic constituents (even though none of the experiences seem to be very pleasant)... caulerpin and its derivatives look like good leads for future research: http://bigmknows.posterous.com/hallucinoge...n-investigation

Mutant : 21. Hunab's got a few more years on that. That's an admirable way to approach such things. Rationalising the irrational world we live in is hard, if not impossible... it really is up to the individual to find what they believe in. Wise points, thanks for bringing them up. I do think that there is a strong potential for psychedelics to be of benefit, even after unpleasant experiences. It's up to the informed user to make their own sensible decisions. Easy to make mistakes... but there is no better way to learn.

Very generous offer Sethomopod! Will PM you and sort out a trade. Thanks

This patent might give you some clues on how to use the stuff. http://www.freepatentsonline.com/7410656.html Plus a few reports from users: http://plantmed.blogspot.com/2004_01_01_pl...d_archive.html#

The square root of three times the radius. So, height = 2r + sqrt(3r) = 1 + sqrt(1.5) ~ 2.2247 cm

Thanks again for your help planthelper - I appreciate it. I'll have to check out some botanic garden plant listings in SA and see if there are any suitable plants around locally. Cheers. See new post on hederagenin, a potentially potent triple reuptake inhibitor: The extracts of Fructus Akebiae, a preparation containing 90% of the active ingredient hederagenin: serotonin, norepinephrine and dopamine reuptake inhibitor. Fructus Akebiae is a traditional Chinese herbal extract that has been used for the treatment of depressive disorders in China. Previous studies demonstrated that Fructus Akebiae extracts (FAE) displayed a potent antidepressant-like activity in animal behavior tests and found that the specific active ingredient from the extracts of Fructus Akebiae is hederagenin. However, the underlying mechanism is unknown. Here we provide evidences that FAE enhances the signaling of central monoamines via inhibition of the reuptake of the extracellular monoamines including serotonin (5-HT), norepinephrine (NE) and dopamine (DA). In rat brain membrane preparations and HEK293 cells transfected with human serotonin transporter (SERT), NE transporter (NET) and DA transporter (DAT), we found that FAE displayed marked affinity to rat and cloned human monoamine transporters in ex vivo and in vitro experiments, using competitive radio ligand binding assay. In uptake assays using rat synaptosomes and transfected cells, FAE was found to significantly inhibit all three monoamine transporters in a dose- and time-dependent manner, with a comparable or better potency to their corresponding specific inhibitors. In contrast, FAE (10 μM), showed no significant affinity to a variety array of receptors tested from CNS. In support of our uptake data, in vivo microdialysis studies showed that administration of FAE (12.6, 25, 50 mg/kg) significantly increased extracellular concentrations of 5-HT, NE and DA in frontal cortex of freely moving rats. Taken together, our current study showed for the first time that FAE is a novel triple inhibitor of monoamine transporters, which may be one the mechanisms of its antidepressant activity

Thanks for the article, one for the insomniacs.... I think making a case against a "Spirit World Model" is dangerous for some of those who venture into the unknown realms of consciousness (often getting there accidently). I might be a unique case but I feel that using a 'spirit world model' for basing my thoughts and visions on, when I was medically psychotic, was the ONLY way my brain could rationalise what I'd experienced. I'd been a pure evidence based science-only person before then, but when things went bad, science and evidence-based rationale was not suitable for integrating the sensory experiences with "mentally logic" that was understandable. After days of seeing/hearing stuff that wasn't really there and having no control at all, attempting to rationalise what I'd experienced with spirit and mystical dimensions was my only way to hang onto the last fragments of sanity and understanding. No way could I have escaped from my psychotic states by merely rationalising everything as being wonderful brain-candy. I had no choice but to put some reliance in the unknown mystical aspects just to integrate my mind-state enough to escape the realms of psychosis. "Spirits" and other mystical entities will remain as the main tools my brain will use to interpret a altered state if it needs to... and I'd definitely encourage anyone who found themselves in a "reality" they didn't like to expand on mysticism and spirits to guide their trip. I think that it can be hard for some psychonauts to interpret, integrate and expand into the real world their experiences, without some reliance on mythical spirits and the like. Not saying spirits etc. exist, but they seem to be a healthy way to understand what goes on in ones mind... even if the brain did wonderfully construct the illusions out of nothing. I like to think that it's spiritual enlightenment... If ones developed frame of mind helps a person to have a happy and meaningful life without harming others, who should tell them that they are crazy with "chronic recurrent delusional psychosis" and force them to reconsider the meaning of life? Shouldn't we be entitled to freedom of thought?

Thanks for the pics Planthelper - unfortunately I don't think I'll have luck with finding anything like that... Do you have any idea if Aristolochia constricta or other "protopine(s)" yielding plants are easier to obtain?

T st, Not sure about protopine being a dissociative... It does seem like an interesting substance though, especially for pain relief - triple action analgesia with opioid, calcium channel and adrenergic receptor actions sounds good. Are the botanical sources easy to obtain?

Ahh atleast you caught something, even if they were small. I'll be waiting for that birthday cake, make sure it's nice and "spiced up" if you don't mind

Happy Birthday - you have any luck at Gunamatta with the fishing lsdreamz? (and happy birthday to the germinator while I'm at it)

I had my first sub dream last night - very strange for considering I rarely dream (or recall it). This is the first season I've had a shroom related dream, so it possibly takes a bit of experience with the mushrooms before one can tune into the phenomenon. Might have to get out this weekend (and in a weeks time) and have a look... Sweet dreams everyone!

The following Middle-Eastern acacias are reported to contain DMT (probably low concentrations): Acacia albida: DMT in leaf (TiHKAL*) Acacia nilotica: DMT in the leaf (TiHKAL*, Trout's Notes) Acacia senegal: DMT in the leaf (TiHKAL*) Acacia tortilis: DMT, NMT, and other tryptamines (No reference given, http://www.dmt-nexus.com/forum/default.asp...sts&t=1123) *Some websites quote PiHKAL as the source http://www.rollitup.org/spirituality-sexua...-ethnogens.html

Protopine inhibits serotonin transporter and noradrenaline transporter and has the antidepressant-like effect in mice models Neuropharmacology, Volume 50, Issue 8, June 2006, pp. 934-940 Abstract The protopine isolated from a Chinese herb Dactylicapnos scandens Hutch was identified as an inhibitor of both serotonin transporter and noradrenaline transporter in vitro assays. 5-hydroxy-DL-tryptophan(5-HTP)-induced head twitch response (HTR) and tail suspension test were adopted to study whether protopine has anti-depression effect in mice using reference antidepressant fluoxetine and desipramine as positive controls. In HTR test, protopine at doses of 5, 10, 20 mg/kg dose dependently increase the number of 5-HTP-induced HTR. Protopine at doses of 3.75 mg/kg, 7.5 mg/kg and 30 mg/kg also produces a dose-dependent reduction in immobility in the tail suspension test. The present results open up new possibilities for the use of protopine in the treatment of mood disorders, such as mild and moderate states of depression. http://linkinghub.elsevier.com/retrieve/pi...028390806000116 (Protopine also has actions as a Ca2+ channel blocker and antiplatelet agent)

Thanks for sharing - good article. Nothing like a few months on too much paroxetine to bring out some serious delusional ideations and psychosis... Much worse than any delusional state I've been in with a psychedelic. ...anyway, off to start another religion.

"Indole alkaloid" could just be used as a term for serotonin in this case. Would be nice if there was something more active in bananas but I doubt it. The psychedelic properties of banana peel: an appraisal http://www.springerlink.com/content/02060r...58/fulltext.pdf 6-hydroxy-1-methyl-1,2,3,4-tetrahydro-β-carboline found in bananas: http://pubs.acs.org/doi/abs/10.1021/jf030324h I tried smoking banana peel as a kid - tasted good... don't think I got any effect from it.

Only have access to the first one at the moment: The_Kava_Anxiety_Depression_Spectrum_Study.pdf (Assume it's similar to the Complementary Therapies in Medicine paper just with more details...)

I've found this ebay shop to be good: http://stores.ebay.com.au/Accolent-Dried-H...3QQftidZ2QQtZkm

Legal in Aus. Seems to be fairly common (try local botanic gardens and nurseries) or you can buy at SAB: http://shaman-australis.com.au/shop/index....6d274bf15563f90

Until the professionals answer, here are the relevant pages from Some Simple Tryptamines, 2nd ed. (Keeper of the Trout and Friends, pp. 29-30, 2007). Reported occurrences of DMT: I hope sharing this is not a copyright infringement - I am only posting this online after seeing the comment "Trout's Notes strongly encourages the dissemination of any and all factual information contained within these pages so long as proper acknowledgement of the authorships and original sources of data origin are maintained." Mods, please let me know if there are any issues.

I wouldn't combine them (or would use greatly reduced doses): That said, benzodiazepines are sometimes recommended for the emergency treatment of muscimol-induced seizures/myoclonus and in animal studies, attenuate the hypnotic effects of the drug. It's safer to assume there will be potentiation - even if there are preliminary animal studies to the contrary.