I found L-Tryptophan or 5-HTP helped keep my anxiety under control and mood's manageable and consitent and improved my motivation.Although I was using them during a period of long term heavy cannabis use and it seemed to keep things balanced, I also found that the morning was the optimal time to take them,If i did take either of them in the evening sleep was impossible.Also a few times I felt like i was "cooking out" I think less is more with both substances.*Note I took one or the other at different periods not combined the cooking out only occured from the 5-HTP.