clayzorr

Abilify generally has less anti-dopamine effects than other anti-psychotics; it acts as a "partial agonist" at the D2-like receptors... therefore technically having some dopaminergic effects..however, it's 'life-sucking' and anxiogenic effects come from histamine antagonism and adrenergic actions, respectively. It blocks both alpha and beta-adrenaline receptors - the alpha-2-blockade leads to increased noradrenaline - however, the combined blockade of the other receptors lead to the generally negative 'feelings' because the brain/body is distorted..trying to figure out where to put the adrenaline that is no longer binding properly..it would be one thing if you blocked JUST the alpha-receptors; that wouldn't be so bad..but because it blocks beta's as well...this is part of why one would feel lifeless on it. Also, Abilify has 'partial agonist' effects at some serotonin receptors - this makes it less linear than other anti-psychs which generally block serotonin's effects...the partial agonist activities at receptors like 2C and 7A can lead to anxiety....I would try to switch to Clozapine or something like that... You can also add an H3R antagonist...that would help minimize the sedative effects of ANY psych drugs - and it would improve cognition and psychotic symptoms in the process...so something like "Pitolisant" which can be bought @ tht.co