Jump to content
The Corroboree

Leaderboard


Popular Content

Showing content with the highest reputation on 26/05/23 in all areas

  1. 1 point
  2. 1 point
    Both harmine and harmaline are reversible inhibitors of monoamine oxidase A (RIMAs). The mechanism of action is different to irreversible MAOIs like: Isocarboxazid, Phenelzine or Tranylcypromine. The bonds for reversible inhibitors are more easily broken as they are bonded through non-covalent mechanisms. Irreversible MAIOs permanently inhibited and altering the receptor site they target. Which is why pharmaceutical MAOIs have more dangerous interactions, whereas many who have extensive use with harmala will tell you the fears are offstated. Ofcourse mixing harmala with stimulants, certain pharmaceuticals, amphetamines etc isn't a good idea and there are ofcourse other factors such as half lives etc, but generally interactions with harmala are overstated. Now THH found in caapi is a bit different. It is thought to be a SRI with minimal reversible MAO-A activity. But i believe this is still controversial.
×