Alchemica Posted August 3, 2014 Selective MAO-B inhibitors: a lesson from natural products Monoamine oxidases (MAOs) are mitochondrial bound enzymes,which catalyze the oxidative deamination of monoamine neurotransmitters. Inside the brain, MAOs are present in two isoforms:MAO-A and MAO-B. The activity of MAO-B is generally higher in patients affected by neurodegenerative diseases like Alzheimer’s and Parkinson’s. Therefore, the search for potent and selective MAO-B inhibitors is still a challenge for medicinal chemists. Nature has always been a source of inspiration for the discovery of new lead compounds. Moreover, natural medicine is a major component in all traditional medicine systems. In this review, we present the latest discoveries in the search for selective MAO-B inhibitors from natural sources. For clarity, compounds have been classified on the basis of structural analogy or source: flavonoids, xanthones, tannins, proanthocyanidins, iridoid glucosides, curcumin, alkaloids, cannabinoids, and natural sources extracts. MAO inhibition values reported in the text are not always consistent due to the high variability of MAO sources (bovine, pig, rat brain or liver, and human) and to the heterogeneity of the experimental protocols used. DOI 10.1007/s11030-013-9490-6 review MAO-B natural.pdf See also: Flavonoids and the CNS New insights into the biological properties of Crocus sativus L.: chemical modifications, human monoamine oxidases inhibition and molecular modeling studies.review MAO-B natural.pdf review MAO-B natural.pdf 4 Share this post Link to post Share on other sites
Just Dean Posted September 16, 2014 Isn't australian willow a MOA-B ?? Share this post Link to post Share on other sites
Dreamwalker. Posted September 16, 2014 (edited) & if you prefer unnatural.... https://en.wikipedia.org/wiki/Selegiline "(Anipryl, L-deprenyl, Eldepryl, Emsam, Zelapar) is a drug used for the treatment of early-stage Parkinson's disease, depression and dementia. In normal clinical doses it is a selective irreversible MAO-B inhibitor." Edited September 16, 2014 by Dreamwalker. Share this post Link to post Share on other sites
Alchemica Posted September 22, 2014 Isn't australian willow a MOA-B ?? See https://en.wikipedia.org/wiki/Geiparvarin Share this post Link to post Share on other sites
