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mindperformer

Anxiolytics and BZD-active plants

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By the way: Scutellaria baicalensis contains not only the anxiolytic flavonoids but also a high amount of the famous endogen sleep hormone Melatonin:

http://www.herbs.org.../melatonin.html

 

i only experimented and grew the american scullcap, scutellaria lateriflora, but realy liked it as a tea, and it grows into a compact plant giving you lot's of herb for little space wasted. so far i could not buy scullcap tea in oz.

the scullcap tea in england, once seemed to have potentiated coca tea, i can't remeber the brandname though dr. something, i wonder if this, experience has it's merits?

mp,

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Dysmenine contained Scutellarin from Scutellaria laterifolia, Cannabis and Cypripedin from the lady's slipper orchid:

http://herbmuseum.ca/node/1666

I didn't know that it was also combined with coca...

For me the american scullcap worked good for sleep, but weak, the S. baicalensis had additional anxiolytic effects and was only sedative in high doses.

Scutellaria baicalensis:

5ouxdg.jpg

in flower:

14y3990.jpg

fresh twigs in spring:

nxl82f.jpg

Scutellaria barbata (used in TCM):

ndv4gx.jpg

Scutellaria laterifolia:

2b2tdl.jpg

in flower:

2s6lxg6.jpg

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More on Uzara (Xysmalobium undulatum):

It occurs in Kenya, Tanzania, Malawi, Zambia, Angola, Namibia, Botswana, Zimbabwe, Mozambique, Lesotho, Swaziland and South Africa.

The pulverized root is used as snuff to treat headache and hysteria, as a sedative and hypnotic, it is also snuffed by the Zulu for a sedative effect. The plant enters into religious rituals to divert storms, prevent poisoning and to make dogs keen hunters. Ethanolic leaf and root extracts exhibited CNS depressant activity in the GABA-A-BZD-receptor assay and showed significant antidepressant activity by exhibiting high affinity to the serotonin transport protein (SERT). It is also regarded as good aphrodisiac (in Zimbabwe and South Africa).

The Xhosa in South Africa, and generally throughout southern Africa the root of this plant is used for indigestion, migraine, common cold and other indications. Uzarin and Xysmalorin inhibit motility in the small intestine and are structurally related to cardiac glycosides, but poorly absorbed, only high doses have a cardiotonic effect.

The most unique substance found in Uzara-roots was Allopregnanolone (as a glycoside) along with the precursor Progesterone. Allopregnanolone is an endogene neuro-steroid with narcotic activity and action on the barbiturate-subunit of GABA-receptors (described in the first post of this thread). The studies:

http://www.jstor.org/discover/10.2307/76155?uid=3737528&uid=2129&uid=2&uid=70&uid=4&sid=21101324374627

Allopregnanolone (and enhancing the endogene neurosteroids like Allopreg., Epipreg. and THDOC) is also regarded as new pathway of antidepressant action and against social phobia:

http://www.sciencedaily.com/releases/1999/11/991110061714.htm

http://www.ncbi.nlm.nih.gov/pubmed/12171387

The synthetic Allopregnanolone- derivative Ganaxolone is used as an anesthetic and has sedative, anxiolytic and anticonvulsant effects.

Gelsemium sempervirens can be used in very careful dosages for enhancement of endogene Allopregnanolone.

Uzara root is available as tincture in pharmacies. It is regarded as one of the best remedies against diarrhea in small doses and in higher doses as a good antidepressant socializing sedative.

The seeds:

j5v2nr.jpg

downside 24-fold:

th_384507263_Xysmalobiumundulatum_Samen9x5_122_475lo.JPG

upside, 24-fold:

th_384565323_Xysmalobiumundulatum_Samen9x9_122_342lo.JPG

The plant:

http://www.ispot.org.za/node/146245

Edited by mindperformer

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LOL @ Teotz reference

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all these plant references to BZD action, when Torsten himself knows that he has in his hands probably the most potent BZD agonist, pure, natural and derived. And yet will not share his discoveries with anyone!

Allopregnanololone sounds like it would be pretty to investigate. I'm intrigued!

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whhhhhhhhhhheyyy! so we should look at actions of allopregnanolone. I Like he sound the anecdotal reports.

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I have also experienced with progesterone oral sprays, the main precursor of Allopregnanolone

and even an extremely low dose of Gelsemia s.- root tincture potentiated it

Edited by mindperformer

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