Jump to content
The Corroboree
Sign in to follow this  
Alchemica

Free Lobelia cardinalis seed

Recommended Posts

Posted (edited)

I've been interested in this Lobelia as a potentially superior (?) alternative plant to L. inflata.

 

DSC_0000252.thumb.jpg.205af70585282d861d90b9af84c49f07.jpglobinaline.thumb.jpg.9899c10c5b5b3e2ef17fefe97c3b4f88.jpg

 

'The Penobscot people smoked the dried leaves as a substitute for tobacco. It may also have been chewed'.
 
Lobinaline caused a significant, dose-dependent increase in dopamine release and preclinical and clinical data exist that support nAChR-based ligands as promising therapeutic agents for the treatment of depression, alcohol and drug dependence. The alkaloid has been proposed as a treatment for Parkinson's and psychostimulant abuse [1].
 
Lobinaline appears to be distinct from nicotine and lobeline in terms of its selectivity and functional effects at nAchRs and is a DAT inhibitor. Compared to other plant metabolites, such as nicotine and lobeline, lobinaline is relatively non-selective with respect to α4β2- and α7-nAchRs
 
Lobinaline displays appropriate pharmacokinetics and low mammalian toxicity in mice relative to lobeline, the most widely studied Lobelia alkaloid.
 
Haven't bioassayed myself but if anyone wants to grow it (say first 3 replies in this thread and PMs) let me know. Seed was collected from the plant pictured.

No TAS/WA sorry. 
 
Edited by Alchemica
  • Like 1

Share this post


Link to post
Share on other sites

Hi Alchemia, 

I'd love to give growing this a try! 

Will PM

Thanks, P

Share this post


Link to post
Share on other sites

I'd love to try growing this, would be much appreciated

Share this post


Link to post
Share on other sites

Thanks for the interest, have three people!

Share this post


Link to post
Share on other sites

No seed to W.A ?    I can understand your stance on sending live plant material to W.A or TAS, but no seed is a bit extreme ? Is it a weed in these states ?

Share this post


Link to post
Share on other sites

-just trying my best to be legit without even knowing what I have to technically be legit about... if it's not an issue I still have a few seed pods on their way and can plonk them to where permissible. From what I've heard TAS is pretty strict on even seed

  • Like 1

Share this post


Link to post
Share on other sites
Posted (edited)

Yeh fair call. Nothing wrong with being too careful .Seeds are usually ok though. Unless banned or listed as a weed :wink:

 

edit:  and upon further research it turns out that you are doing the right thing as these plants are in fact listed as potential invasive species in W.A B)

Edited by mr b.caapi

Share this post


Link to post
Share on other sites
Posted (edited)

I've got quite a few of these going from seed, small seedlings now, but if anyone missed out (note: state restrictions still apply) and has a SERIOUS actual interest in the plant let me know and I'll try and gift you a small plant once they're a bit bigger, otherwise they get donated to the dark-side of aesthetic flower appreciating grandmas

 

Traditional use: Root infusion for worms, rheumatism; leaf infusion for colds, fever; root poultice for sores

 

Constituents [1]:

 

Aerial parts: alkaloid lobinaline
Hairy root culture: diacetylene triol lobetyol + glucosides lobetyolin and lobetyolinin
Leaves: anthocyanin cyanidin-3-O-[6-O-(4-O-E-p-coumaroyl-O-α-rhamnopyranosyl)-βglucopyrano]-5-O-β-glucopyranoside

 

 

See more: https://www.cargocultcafe.com/tag/plant-identification-lobelia-cardinalis/

 

Some initial bioassays [2]:

 

Positive

"when it comes to stimulation, cardinalis is more like nicotine.  Seems to give stimulant effects similar to mild nicotine. Seems to have mild aphrodisiac properties.  Slight mood lift present it also seems to have anti depressant properties.

 

...the anti-depressant effects cannot be compared to anything - because you just feel better, it's not anything like pharmaceutical anti-depressants. 

 

...it's painkilling potential is huge. powerful muscle relaxant and really potent painkiller..."

 

Less positive:

"L. inflata is far more effective than L. cardinalis and L. siphilitica in my opinion."

 

[1] http://dx.doi.org/10.3390/medicines5040121
[2] https://drugs-forum.com/threads/lobelia-cardinalis.213716/

Edited by Alchemica

Share this post


Link to post
Share on other sites

Create an account or sign in to comment

You need to be a member in order to leave a comment

Create an account

Sign up for a new account in our community. It's easy!

Register a new account

Sign in

Already have an account? Sign in here.

Sign In Now
Sign in to follow this  

×