Alchemica Posted May 3, 2019 Comprehensive review on the interaction between natural compounds and brain receptors: Benefits and toxicity [sci-hub] In case anyone wanted things to add to their bucket list... or needed a natural product for that receptor... Includes: Natural products interacting with nicotinic nAChR and with mAChR. Natural products interacting with ionotropic and metabotropic glutamate receptors. Natural products interacting with γ-Aminobutyric acid type A receptors (GABAAR). Natural products interacting with cannabinoid (CBR) type 1 (CB1R) and type 2 (CB2R) receptors Natural products interacting with dopamine receptors (DAR). Natural products that act on insulin receptors and insulin-like growth factor receptors (IGFRs). Natural products acting on receptors for advanced glycation end-product receptors (RAGE). Natural products interacting with receptors associated with neurotrophic factors (NTF). Natural products that interact with immune system receptors. Natural products that interact with the scavenger receptors associated with oxidative stress. Natural products that interact with peroxisome proliferator-activated receptors (PPAR) Natural products that interact with ApoE or LDL receptors. 1 Share this post Link to post Share on other sites
Alchemica Posted May 3, 2019 Having a proper read through the tables, a little disappointed. One that stood out to me was 3',4',5',5,6,7-hexamethoxyflavone (Eremophila debilis) Flavonoid Binding activity to M1 mAChRs "The aerial parts of the endemic Australian plant Eremophila debilis (Myoporaceae) contain 3% dry weight of the biologically active 5,6,7,3',4',5'-hexamethoxyflavone" [1] I'd in the past experimented with some different Eremophilas (longifolia etc) thinking it might be phenylpropanoid EOs making it such a respected bush medicine. This adds an interesting aspect - a flavonoid muscarinic. 1 Share this post Link to post Share on other sites
