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Alchemica

Ashwagandha free seed etc

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If anyone is interested, I have quite a bit of ripe fruit if you want to grow it etc.  Harvested quite a few plants yesterday

 

ashwagandha2.thumb.jpg.3ba3866816b866a9aaed53250ad711ea.jpgashwagandha.thumb.jpg.f97148222b159b8ad92e1491b1787c39.jpg


Can throw in a few other seeds: Calendula, Pyrethrum, Feverfew, Chamomile, Romanesco broccoli, have plenty of Milly's morning glory mix too

 

While the fruit can cause GI distress consumed in large quantities, the withanamides, the primary active constituents in W. somnifera fruit extract exhibited neuroprotective effects. They may improve antioxidant status and reduce proinflammatory markers.These compounds  may work to prevent Alzheimer's disease at the onset, and it also could prevent its progression [1]. This research was once heralded as a major step forward as there is nothing on the market that slows the progression of Alzheimer's. Can't find anything on how this research has progressed unfortunately. The patent extends to use for mood [2]


[1] https://www.sciencedaily.com/releases/2015/03/150311124643.htm
[2] https://patents.google.com/patent/CA2538905C


Also can help out with leaf for research purposes. While it's less used than the root (and some seem to aim to avoid the withaferin-A), I've found it a nice enough medicinal tea and others use it similarly. The neuroprotective leaf and fruit constituents affect cortical muscarinic acetylcholine (including M1/M2 mAChRs) and neurotrophins, which may partly explain it's cognition-enhancing effect.

 

The leaves possess higher content of active withanolides, Withaferin-A and Withanone, as compared to the roots [1]. Nootropic and CNS therapeutic properties of the leaf have been claimed [2].

 

Withaferin-A is a potent leptin sensitiser with additional antidiabetic actions and resulted in a 20-25% reduction of body weight in overweight mice [3]. It improves insulin sensitivity [4].

 

Anti-neuroinflammatory properties have been ascribed to the leaf [5] along with neuroprotective properties [6]

 

Withaferin-A shows anti-neuroinflammatory [7] anti-Aβ properties [8] and dopamine-restoring [9] properties. Improvement of cognitive dysfunction has been ascribed to Withanone [10] including inhibition of AChE, anti-Aβ, protection against oxidative stress and anti-inflammatory effects.

 

Many toxicological studies have demonstrated that Ashwagandha, in its reasonable dose, is a non-toxic, safe and edible herb - despite that, there is sometimes movement away from the cytotoxic constituents towards root extracts which may be less effective

 

[1] https://www.ncbi.nlm.nih.gov/pubmed/27936030
[2] https://www.ncbi.nlm.nih.gov/pubmed/26361721
[3] https://www.ncbi.nlm.nih.gov/pubmed/27479085
[4] https://www.ncbi.nlm.nih.gov/pubmed/30417321
[5] https://www.ncbi.nlm.nih.gov/pubmed/27550017
[6] https://www.ncbi.nlm.nih.gov/pubmed/25789768
[7] https://www.ncbi.nlm.nih.gov/pubmed/26266054
[8] https://www.ncbi.nlm.nih.gov/pubmed/30356847
[9] https://www.ncbi.nlm.nih.gov/pubmed/30544122
[10] https://www.ncbi.nlm.nih.gov/pubmed/29108796

Edited by Alchemica
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@Alchemica you are such an asset to this community! 

 

I would be stoked to get some growing, thanks for the offer. I’ll swing you a pm...

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Thanks so much! Think you can throw in some Chamomile? I hear its good to grow between veggies :) 

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