elephant mammoth clone for you?

[devance]

http://www.physorg.com/news/2011-12-japan-russia-chance-clone-mammoth.html

[Teams from the Sakha Republic's mammoth museum and Japan's Kinki University will launch fully-fledged joint research next year aiming to recreate the giant mammal, Japan's Kyodo News reported from Yakutsk, Russia.

By replacing the nuclei of egg cells from an elephant with those taken from the mammoth's marrow cells, embryos with mammoth DNA can be produced, Kyodo said, citing the researchers.

The scientists will then plant the embryos into elephant wombs for delivery, as the two species are close relatives, the report said.

Securing nuclei with an undamaged gene is essential for the nucleus transplantation technique, it said.

For scientists involved in the research since the late 1990s, finding nuclei with undamaged mammoth genes has been a challenge. Mammoths became extinct about 10,000 years ago.

But the discovery in August of the well-preserved thigh bone in Siberia has increased the chances of a successful cloning.

Global warming has thawed ground in eastern Russia that is usually almost permanently frozen, leading to the discoveries of a number of frozen mammoths, the report said.

http://www.aapsj.org/view.asp?art=aapsj060322\\

[Recently, a mechanism proposed by Timasheff et al3 has been widely accepted by other researchers. In Timasheff’s mechanism, Timasheff explains protein stabilization phenomena in aqueous solutions by small molecular weight stabilizers, such as sodium lactate.3 A stabilizer favors the folded state of the protein when the folded and unfolded forms of the protein coexist in an equilibrium solution. In the presence of a stabilizer, less free energy for the folded native protein increases because there are less exposed surface areas than for the unfolded denatured protein; thus, the unfolded protein exists in the more thermodynamically unfavorable state.

During freezing, the water surrounding a protein would probably be drawn off into an ice crystal matrix and the presumed hydration shell would be disrupted, hence, the same hydration environment as in solution would no longer exist. However, many3 have argued that freezing does not necessarily invalidate the Timasheff mechanism, since a significant fraction of water remains unfrozen in protein formulations.

Our hypothesis was that PEGs could interact with proteins in multiple ways during cryoprotection. Higher molecular weight PEGs protected LDH better than lower molecular weight PEGs in solution and during freeze-thawing.1 A likely explanation for this finding is increased affinity for binding in the higher molecular weight molecules. LDH in its native form is an oligomeric protein.4 An essential requirement for LDH cryoprotection by PEGs is that the stabilizers should favor the association of the tetramer.]

Called PEGS solution.

[Sheather]

Let's bring back extinct species so we can not mind that we're not doing much for the currently endangered ones!

I don't see the point of this. We have enough animals on this planet dying out. We don't need to bring dead ones back just so they can die out again.

[SunChaser]

If we could bring back a species that became extinct over 4 thousand years ago, then maybe we can learn more about what caused that species to become extinct in the first place. If we can learn more about why the animal became extinct, then it might lead to a better understanding of how we can prevent currently endangered species from becoming extinct.

Peace

[mauve]

I find this beautiful.

[cactuscarl]

That's unreal i can't wait to see a mammoth