tryptamine Posted November 27, 2011 (edited) Five new indolizidine alkaloids, grandisines C, D, E, F, and G (4−8), and one known indolizidine alkaloid, (−)-isoelaeocarpiline (3), were isolated from the leaves of Elaeocarpus grandis and their structures determined by 1D and 2D NMR spectroscopy. Grandisine C (4) is isomeric with the known compound rudrakine (1). The absolute configuration of grandisine D (5) was deduced by its conversion to (−)-isoelaeocarpiline. Grandisine E (6) contains a novel tetracyclic ring system. Grandisine F (7) is the 14-amino analogue of grandisine C. Grandisine G (8) contains the novel combination of a piperidine attached to an indolizidine. Grandisines C, D, F, and G and (−)-isoelaeocarpiline showed receptor binding affinity for the human δ-opioid receptor with IC50 values of 14.6, 1.65, 1.55, 75.4, and 9.9 μM, respectively. Attached image is grandisine B. I believe this is grown in Australia for its edible fruit? Anyone tried? Anyone have access to material? Edit: Some more info here: http://www.shaman-australis.com/forum/index.php?showtopic=19498 Edited November 27, 2011 by tryptamine Share this post Link to post Share on other sites
tarenna Posted November 27, 2011 Thanks for the info. The Blue Quandong is a really fast grower and there is no shortage of material available from it. No fruit around for a few months, but plenty of foliage anytime. Share this post Link to post Share on other sites
