Not often I've read any animal angled material here or elsewhere.
I will slowly add to this thread, link some references and my approach, and how things are panning out.
The only "issues" I have come across is the claim in one study of ataxia in male wistar rats with extract, with antidepressant activity. The second is using unfermented raw material with wistar rats which displayed a reduced physiological stress response but produced inflammatory responses.
Cats and dogs have been examined at dosage ranges of 100mg/kg and 10mg/kg twice daily of milled material respectively with no adverse effects.
Wistar rats in another oral toxicity study at 14 and 90 day durations have been observed to have no adverse effects with extract at levels up to 5000mg/kg daily(14 dys) and 600mg/kg daily (90 dys).
Why am I looking at this?
Many dogs can suffer from anxiety, separation anxiety is one common facet with some breeds being more prone.
After the death of our older dog, the "pup" has really amplified her separation anxiety... Lol... Particularly with me... Yeah I be numba one.
Examples include making sure I'm breathing when I've gone down with fatigue on the couch(are you dead?) and getting up in my face. If asleep I'll get a light paw tap on my face to get a response.
Manically barking at me on returns home.... Even short periods. ("berating" bark). The others in the family get this to a lesser degree.
Highly territorial, strong guarding instinct .. Lol... I'll pity the fool that may poke around unannounced come nightfall. Very keen hunting instinct.
Constant "sooking" when I'm outside the house yard doing something and have left her inside it. Previously she would break out and find me in the scrub, but now has established that that is not OK.
Occasionally digging, not often buy when it does occur its a decent excavation.
Gets a heap of exercise, lots of room, heaps of things to chew on ect... Loads of stimulation. Less socialized than desirable though, obedient but strong willed.
Would happily be a lap dog... Lol
She's a crossbreed and currently entire, German short-haired pointer x border collie....
(some are laughing... Yeah WB that might do it) .
So I have a dog capable of running down and taking down a deer, with the intelligence to do it in the most efficient manner.
But if I'm not about.. Lol... She stresses out. When the family is home and I'm out, she is pining and constantly alert for my return . It's quite manic at times.
Interesting enough the smell of fermented skelly is extremely attractive to her. I'll presume it's the "salty" smell it has.
If I have any in my pocket /backpack she is at it. So a few days back I pulled out a tin to chew on a bit and the dog is up on it.... Hmm.... So I dabbed my thumb in an held it out, and the stuff was gone... Lol... Just a dusting on my thumbprint.
Few hours later the already energetic dog has established a new personal best for laps around the house... Lol.. Later in the evening much more settled, rather than the constant vigilance to guarding.
Following day... Less needy, less noise, anxiety appears to be reduced.
Rinse and repeat for three more days, and there appears to be some difference to the severity of the separation anxiety.
So.... Ima gunna drug her... Lol
I'll start establishing a weighted dose and do 30 days and assess again.
Fermented material, ground, sprinkled onto the morning feed. Initially I was thinking morning dosed as the initial increase in activity is quite noticeable.. Lol....
I am reading that 10mg/Kg milled dry kanna twice daily in food is well tolerated by canines with no identified adverse effects* (very comprehensive testing and monitoring).
This is where I will be starting this trial.... I'm hoping it can be used for a period to break some behaviors, but currently i am not adverse to ongoing maintenance use if well tolerated.
* Hirabayashi, M., Ichikawa, K., Fukushima, R., Uchino, T., Shimada, H., 2002. Clinical
application of South African tea on dementia dog. Japanese Journal of Small
Animal Practice 21, 109–113(in Japanese)