Wile E. Peyote

Bargain!

Whatcha got?

Had to make a sudden trip to Sydney so I won't be able to make it Enjoy, I'll be jealous!

Got a glochid in my eye while coming up on acid, spent the night in emergency where someone died right in front of me. What a weekend...

Just linked to the FB group. Not sure how many people on there are actually on the forum though :/

I should mention - old freezer pollen is fine by me. Gonna have way more flowers than I will pollen, so better something than nothing!

Title says it all, looking for a stack of trich pollen. Happy to split the results or pay cash, whatever suits.

Keen!

Ogunbodede, O., et al., New mescaline concentrations from 14 taxacultivars ofEchinopsisspp. Cactaceae San Pedro and their relevance to shamanic practice. J. Ethnopharmacol. 2010.pdf

I'm hoping I will be free Sunday, although the garden at the new place is pretty disappointing - I think I'll be a bit embarrassed to show it off. Maybe I'll just come for a perv ;)

https://www.aodmediawatch.com.au/psychedelics-and-the-tga-what-journalists-need-to-know/

https://clinicaltrials.gov/ct2/show/NCT04516902

Ok, so drug activity at the 5ht2b receptor has been linked to cardiovascular issues: https://www.ahajournals.org/doi/10.1161/01.CIR.102.23.2836 https://www.nejm.org/doi/full/10.1056/NEJMp068265 People with high blood pressure are often excluded from clinical studies with LSD due to the association with increased cardiovascular activity: https://onlinelibrary.wiley.com/doi/full/10.1111/j.1755-5949.2008.00059.x As I understand it, there is still some lesser affinity of psilocybin/psilocin for 5ht2b. I haven't been able to find any info on mescaline affinity 5ht2b. I'd be interested to compare the affinity of mescaline and psilocybin, as you might be able to infer that the substance with the least affinity would have the least cardiovascular risk.

I think the phase 3 clinical trials of MDMA assisted psychotherapy will be a critical piece of evidence in the current consideration of MDMA rescheduling with the TGA. It is an exciting area and a pity there is not more evidence concerning this therapy for other conditions. If the new schedule is made I suspect access will be for PTSD sufferers alone. Microdosing psychedelics is a bit of a tricky concept. Pharmacologically, microdosing would imply there is no pharmacological effect. With psychedelic microdosing, there is a pharmacological effect but the psychoactive effects are subperceptual. I have read anecdotal reports of nausea with mescaline microdosing. Perhaps some people are less susceptible to this. I also think this nausea might reduce once a bit of a tolerance has built up. Very little research has been done in this area unfortunately.

What a fantastic episode. Some highlights - Nichols burns Strassman on endogenous DMT, suggests some concerns about the 5ht2b receptor and microdosing LSD, and talks about the background of the Heffter institute. https://drugscience.org.uk/podcast/27-pharmacology-of-drugs/ If anyone has more information to share about 5ht2b and microdosing risks, please share them. I'm going to do some more research on this topic and will share anything I find here. LSD seems often to be the substance of choice for microdosing as many people find psilocybin tiring and mescaline nausea inducing, so I think it is important to find the harm reduction message here.