Change

The full article is really interesting, monitoring epigenetic changes in gene expression, of genes associated with anti-aging and pro-aging, seems like a way better method than a simple memory test. http://sci-hub.io/10.1038/nm.4311 copied from article This result indicates that THC treatment affects molecular processes relevant to cell plasticity and signaling in mature animals. Upregulated transcripts included Klotho (Kl) (Fig. 2d and Supplementary Figs. 5 and 6), which is known to extend lifespan in different species 12–14 and to improve cognition15; transthyretin (Ttr), a gene that is thought to be protective against Alzheimer’s disease16,17; and brain-derived neurotrophic factor (Bdnf), an important neurotrophic factor that enhances synapse formation18 and cognitive functions19,20. The two transcripts that were most strongly downregulated in the mice after THC treatment corresponded to genes with potential pro-aging effects: caspase-1 (Casp1), which is involved in age-related impairments in cognition21, and connective tissue growth factor (Ctgf), which is known to enhance the pro-apoptotic activity of transforming growth factor β (TGF-β)22 (Supplementary Fig. 7). Together, these results demonstrate that the cognitive improvements in THC-treated mature mice were associated with a change in gene profiles; these changes and the associated cognitive improvements both lasted for several weeks after cessation of the treatment. The directions of the expression changes were such that the profiles of mature, THC-treated mice were most similar to those of young control mice, whereas THC treatment of young mice resulted in a gene expression pattern that was similar to that of vehicle-treated mature animals. This indicates that the enhanced CB1 tone achieved through low-dose THC treatment may have normalized the weak cannabinoid signaling signature in mature animals and thus reverted some of the age-related changes in gene expression, whereby several genes with antiaging effects were upregulated while genes contributing to aging were downregulated.

When i come across someone with interesting ideas, to check the validity of such ideas, the first thing i do is search for critical opinions, then try to work out if the criticisms are based in flaws in the concepts or character assassination. Generally speaking if the ideas are rubbish there is plenty of evidence to show why, however if the criticisms focus on attacking the person's character instead of addressing the issues, its much more likely the criticisms are based in the bias the reviewers hold and therefore warrant further investigation. Here are a few criticisms of Guy McPherson i found online. Ill let you decide if you consider these to be reasonable criticisms of his work or just character assassination. Analysis of the data by knowledgeable science educators such as Scott K. Johnson[7] and working scientists such as Michael Tobis[8]shows that McPherson wildly distorts climate science — especially developments about methane emissions from the Arctic — to support his conclusions. They also refute his claims related to runaway climate "feedbacks" as, variously, "not fast enough", not meeting the technical description of positive feedbacks, or actually constituting negative feedbacks. Additionally, Tobis points out that some of McPherson's statements — such as one nonsensical prediction of chain nuclear meltdowns — have literally nothing to do with climate science. McPherson also claims that the United States government, and virtually all high-profile scientists and activists (like James Hansen), know we are beyond the point of no return, but are purposefully making conservative predictions to mislead the public. Radio host Alex Smith explored the problematic reasoning and possible motivations behind McPherson's nihilistic views[9] and also researched dubious sources of the purported extinction date,[10] on the weekly Ecoshock program. A quick review of any of the comments McPherson et al. make on critical articles, or the edit history of this very page, reveals that McPherson and his followers are quick to react to criticism with the predictable set of ad hominem attacks ("white male science," etc.) rather than with rational, peer-reviewed, or otherwise widely accepted scientific arguments. McPherson himself — again, see his apparent attempts at vandalism[11] — admits to cherry picking data that support his views.[12]

That’s hectic, you always were a fire bug but I never imagined it would lead to an arrest. You’re a smart guy, play the game, get your freedom back.

Good! Its extremely addictive, and offers minimal therapeutic value.

First its quantum physics, next it's theoretical physics lets face it, this is a thread about the world being flat, there isnt any physics happening here.

Hey @bardo I hope you dont feel like im twisting your words again What makes you feel these two phenomenons are related? Are you referring to a specific vaccine, or are you equally paranoid about them all? Try to keep in mind that correlation doesn't imply causation.

Sorry if you feel im twisting ya words bro @bardo, i just directly quote the part of your message that confused me. So what were you saying about Quantum Physics?

What experts in the field of Quantum Physics have theories that correlate with the earth being flat?

Some words of wisdom from my brother in spirit, JP Or for the more mathematically minded

idunno if its ironic or moronic that flat earthers happily use mobile phone technology that requires the use of functional satellite while simultaneously asserting ludicrous claims. Fwiw, this thread isnt a debate, debates present evidence then argue for or against the validity of such evidence. This thread was just the OP claiming to perform calculations that lead to his/her conclusion that the world was flat, but when questioned to provide those calculation for the rest of the world to see, he/she linked a youtube video and admitted they didn't do any maths. Flat earthers constantly demanding proof is an indication that they aren't prepared to put in the effort to obtain proof for themselves. If you wanna provide evidence to support the claim the earth is flat, then please do. But the burden of proof should be on the person asserting the extraordinary claim, not the other way around. All you hippies love to bang on about how important having an open mind is, but please be careful, if your mind opens to far your brain will fall out.

Unfortunately the biomolecules used in the drug swab detection kits are not visible with your eyes, so you're going to have some difficulty believing they exist in the first place. Maybe the flat earthers have a better explanation.

Well the growing season is coming to an end, how is everyone Nitro hybrids looking?

random interesting facts from today's nerding The vital role of miRNAs in gene expression is significant to addiction, specifically alcoholism.[198] Chronic alcohol abuse results in persistent changes in brain function mediated in part by alterations in gene expression.[198] miRNA global regulation of many downstream genes deems significant regarding the reorganization or synaptic connections or long term neuroadaptions involving the behavioral change from alcohol consumption to withdrawal and/or dependence.[199] Up to 35 different miRNAs have been found to be altered in the alcoholic post-mortem brain, all of which target genes that include the regulation of the cell cycle, apoptosis, cell adhesion, nervous system development and cell signaling.[198] Altered miRNA levels were found in the medial prefrontal cortex of alcohol-dependent mice, suggesting the role of miRNA in orchestrating translational imbalances and the creation of differentially expressed proteins within an area of the brain where complex cognitive behavior and decision making likely originate.[200] miRNAs can be either upregulated or downregulated in response to chronic alcohol use. miR-206 expression increased in the prefrontal cortex of alcohol-dependent rats, targeting the transcription factor brain-derived neurotrophic factor (BDNF) and ultimately reducing its expression. BDNF plays a critical role in the formation and maturation of new neurons and synapses, suggesting a possible implication in synapse growth/synaptic plasticity in alcohol abusers.[201] miR-155, important in regulating alcohol-induced neuroinflammation responses, was found to be upregulated, suggesting the role of microglia and inflammatory cytokines in alcohol pathophysiology.[202] Downregulation of miR-382 was found in the nucleus accumbens, a structure in the basal forebrain significant in regulating feelings of reward that power motivational habits. miR-382 is the target for the dopamine receptor D1 (DRD1), and its overexpression results in the upregulation of DRD1 and delta fosB, a transcription factor that activates a series of transcription events in the nucleus accumbens that ultimately result in addictive behaviors.[203] Alternatively, overexpressing miR-382 resulted in attenuated drinking and the inhibition of DRD1 and delta fosB upregulation in rat models of alcoholism, demonstrating the possibility of using miRNA-targeted pharmaceuticals in treatments.[203]

They start talking about this @ 51 mins http://eartheart.com.au/healing-services/ajna-light-therapy/ sounds crazy, has anyone here tried it?

2015 1. Lumberjackus x TPM2. Psycho0 x TPM3. Sharxx Blue x TPM4. TPM x Sharxx Blue5. TPM x Huarazensis6. Lumberjackus x Sharxx Blue

This clip is visually spectacular, enjoy