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Alchemica

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Everything posted by Alchemica

  1. Alchemica

    IMG_20181018_092359.jpg

    From the album: Healing in the gardens

  2. I thought I'd share here a project from last year that gave me hope and healing through a community garden and how such can positively impact mental health I have to find more ways to do projects like this, it was the first thing in a long time that improved my mental health Late last year was the first time I've achieved a longer-term personal goal in a very long time. It's hard for people to understand when the goal-oriented, sequential step-by-step organisation for a longer-term outcome part of your brain doesn't work properly just exactly how hard that is. In doing that, I managed to take the desolate wasteland of illness and imbued some hope, meaning, purpose and contribution. That process is reflected in the garden pictures below. It's taken me a long time to start re-investing the illness force, allegiance to the pain, back into healthy things. I had invested a lot of my super scattered ill energy at the community garden and got a medicinal garden out of it through trial and error It helped me develop a special healing relationship with plants while so ill. The medicinal patch became a sacred healing space for me to start caring for my personal ecosystem and stay connected to the community. I enjoyed the medicinal patch as growing things was intrinsically motivated and there was no rigidity to an outcome - any success was a win and boost to self-esteem, any failure no big deal It provided some vital aspects - something to care for beyond the self - novelty and seeing things burst to life - Trial and error approaches, without ANY expectation of outcomes other than giving things a go - Celebrating any small outcome of success, not "meeting quotas" Like my life... initially barren, empty, dry Learning to rise from the darkness by growing seeds First glimmers of light Growth Coming to bloom Returning full circle. My lessons in attempting a medicinal patch despite being functionally very impaired: It's very different going from pots and home gardening and buying lots of plants to community garden plot planting from seed. Particularly going essentially solo and with severe functional impairments. 1. Start simple and get simple happening in the plot first before you go in anyway complicated. If the world of herbal medicinal plants too over enthuses you, pick just a few functional plants to fill a patch initially. Get a feel for it as you go and up your commitment as you see how things fare 2. You'll need so much time if you're starting from seed vs the rapid growth expected from conventional veggie gardening and faster plants etc. Some are slow projects from seed. White Sage, Dan Shen etc 3. Be patient for the seasons. Jumping in early even with a heat mat and greenhouse can just cause issues. 4. Work out weed control and watering options for warm months. For me, despite thinking I got all the soil 'good enough' prepared, weeds were problematic
  3. There was space at a local community garden that was unused and unloved that was kindly offered. I'd suggest utilising local community garden land if it is at all available, sure keep the plants community friendly but you'd be surprised, often these community gardens are up for something people are enthused about beyond the normal food
  4. Alchemica

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    From the album: Healing in the gardens

  5. Alchemica

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    From the album: Healing in the gardens

  6. Alchemica

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    From the album: Healing in the gardens

  7. Alchemica

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    From the album: Healing in the gardens

  8. Alchemica

    IMG_20181218_115541.jpg

    From the album: Healing in the gardens

  9. Alchemica

    IMG_20181218_120608.jpg

    From the album: Healing in the gardens

  10. Alchemica

    IMG_20181014_152607.jpg

    From the album: Healing in the gardens

  11. Alchemica

    IMG_20181016_161940.jpg

    From the album: Healing in the gardens

  12. Alchemica

    IMG_20190108_132739.jpg

    From the album: Healing in the gardens

  13. Ketosis as therapy Heard of a few people doing this, feel free to share your experience We're often centric on putting something in to remedy disease. Taking things out is often less favoured and easy. The nice thing about a diet change is you regain choice of, and gain discipline of what you put into your body and hopefully a health outcome out of it. The second is you can often address the issues of poor health Finding a diet and lifestyle that delivers improvements puts a feeling of health back in your conscious control. I thought, what am I like with very low carbs? I tried exogenous ketones, looking for a fix. What happens with using willpower for better health? I'm still using thiamine but now as a B150 complex and keeping balance in micronutrients including trace elements... my macronutrient profile was not delivering - I was perma-hungry on my relatively planty but carb-loaded diet... keeping up exercise and gardening but so up and down and moody, push through it I tried.... Why not change diet a bit/have another crack at nutritional ketosis? It's "trendy" but also interesting on paper. "...changing diet triggers a deeper consciousness about you" Allowing you to "align your new eating habits with your other new ones in general" Mice on higher glycaemic food showed more autistic behaviors, such as reduced social interactions and activities that seemed to serve no purpose, according to the study, while the low glycaemic mice saw their behaviours improve "Dietary lifestyle changes can have a positive impact throughout the lifespan and appear to not only reduce the risk of acquiring cognitive impairments, but can also attenuate existing impairments: a recent study showed that a 4-week low-saturated fat/low-glycaemic index (GI) diet resulted in improved memory performance and insulin metabolism in adults with amnestic mild cognitive impairment In a healthy young student population those with better glucose regulation perform better on tests of memory, vigilance, planning and dichotic listening compared with those with poorer glucose regulation. A higher-glycemic load diet was associated with higher depression symptoms, total mood disturbance, and fatigue compared to a low-glycemic load diet especially in overweight/obese, but also otherwise healthy, adults" [ref] In ASD, all subjects on the KD had increased BHB, only 50% of subjects demonstrated significant improvements in some studies, some being super-responders with dramatic improvements in social affect. There have been improvement in case studies in hyperactivity, attention span, abnormal reactions to visual and auditory stimuli, usage of objects, adaptability to changes, communication skills, fear, anxiety, and emotional reactions In more serious mental illness, evidence against the role of calorie restriction the mechanism of action of improvement in models, it seems to be more related to ketone bodies I got into meal skipping first. Then low GI, then super carb reduction, then ketotarian. Eventually I was in measurable ketosis, over 1.5mmol/L. Even just getting to breakfast skipping was hard enough without mood going way too low and symptoms initially. Ketosis, it's nice for some conditions on paper but what's it like in reality? "...many people with certain mental disorders find it especially difficult to maintain thanks to the very symptoms they’re looking to manage". "...amid the excitement about the ketogenic diet, I think it’s important to point out its drawbacks as a psychiatric tool." I agree, if you're looking to use a more extreme diet for mental health "wait until your brain is relatively stable before any kind of diet change". I tried getting into ketosis with extreme distress as a baseline once, even helping it along with BHB and I don't recommend it. It didn't work and made things worse. "...after two days of eating fewer than 30 grams of carbs, it hit — a period of low energy and weakness I woke up achy and sluggish, confused and depressed. I was simply too tired to be nervous about anything. But my depression had deepened, sending me into a dull blue fog. Then ten days, each of them torturous." 1. Caloric restriction increases longevity, memory, quality of life and reduces risk factors for neurodegenerative and psychiatric diseases "We suggest that switching between time periods of negative energy balance (short fasts and/or exercise) and positive energy balance (eating and resting) can optimize general health and brain health The increase in autism tracks remarkably closely with the increase in childhood overweight or obesity during the same time period (data from autismspeaks.org and the US Centers for Disease Control), suggesting a causal link between lack of metabolic switching and autistic behaviours, potentially through BDNF expression and excessive mTOR pathway activation" [1] "...metabolic programs relying on efficient fatty acid and ketone body oxidation are most of the time shut off in the modern lifestyle and have to be reintegrated in order to overcome the obesity epidemic – widely known as the breeding ground for most of the Western diseases" The modern lifestyle promotes continuous fueling of adipocytes - most authorities in the Western world recommend at least 50% of the daily caloric intake as carbohydrates but we're losing metabolic flexibility. We have an environment of energy abundance, prolonged psychosocial stress and physical inactivity. It is suggested that "...that the strong increase of diseases related to metabolic abnormalities is largely based on a deficit in metabolic flexibility induced by things like psycho-emotional stress, high meal frequency, physical inactivity etc" It's suggested we need to get used to "periodic fasting or calorie restriction, occasional meal skipping, ketogenic diets and of course exercise. Intermittent fasting and longer-term caloric as well as carbohydrate restriction are parts of our genetic heritage" [ref] There is abnormal hedonic behaviour displayed by diets with high-glycemic carbohydrates - today modern humans are surrounded by a plethora of rewarding stimuli in a nearby environment and through food, we are blunted to the point of reaching reward hyposensitivity What happens with strict carbohydrate restriction to induce adaptation to ketosis? - Improved memory function with a medium effect size in individuals with impairment in response to a relatively brief period of carbohydrate restriction designed to reduce insulin levels and induce ketone metabolism. Improved memory performance, potentially by regulating hippocampal function - Upregulation of GABAergic tone, regulation of glutamatergic transmission (changes the ratio of GABA:glutamate in favor of GABA), dopaminergic and serotonergic modulation along with changes in kynurenine metabolism. Enhanced the availability of brain tryptophan and serotonin, later releases of endogenous endorphins - greater satiety and reduced overall consumption - improved central insulin sensitivity - enhanced cerebral blood flow and blood–brain barrier function - reduced mammalian target of rapamycin (mTOR) expression, similar to the effects of the antidepressant ketamine - dramatic up‐regulation in neuronal autophagy (sometimes referred to as cellular cleansing) - may moderate the pathogenic relationship between stress reactivity and brain in limbic and prefrontal regions - β-hydroxybutyrate increases the frequency of gamma oscillations and has a protective role in executive function in serious mental illness - anti-oxidant/anti-inflammatory action - increases the activity of a family of transcriptional repressors known as sirtuins and broad epigenetic regulatory activities at physiological concentrations, these may alter seeking behaviour, preventing excessive ethanol intake and relapse and facilitate extinction. Enhance GABAergic and glutamatergic plasticities in DA neurons and normalise hyposensitivity to GABA. - activated brain PPARα: through this is likely to regulate expression of many genes encoding enzymes of amino acid/neurotransmitter metabolism and stimulation of PPARα improves cognitive function (reducing cognitive inflexibility, perseveration etc) in models of impaired cognitive function The beneficial effects of caloric restriction may require only a short‐term reduction in caloric intake Some of the things that temporarily flared up were transient worsening of AVHs and not enough energy to want to bother trying to socialise. I was temporarily in quite a negative mindset and not interested in much of anything. Now there are a few elements: 1. Stability of mind, quite a notable difference in consciousness and anxiolysis. A calm, centred softness. Consciousness is becoming clear and slowly expansive again. Still struggling with my memory, eg ingraining things but we'll see how that goes. Normally I struggle with extreme perservation, feel "locked in" to loops, like I'm not in control, "driven" and akathisic. There feels like a liberating sense of me driving choice again. Even social interaction was a relatively normal experience without aberrant emotionality and odd stress responses 2. Lack of hunger and better sleep 3. Clean energy as needed and less inner mind chatter. Normally I feel heavy in body, mind and spirit but today I felt like having an unco grove to music to unwind a bit, just to loosen up a bit 4. A spiritual element. Feeling generally satisfied as I am with a clear horizon. Normally I'm on the chase for something... and then another thing. While I'm trying to put minimal kJ in, it's interesting being in a state where you're burning and using fats, either what you put in, or your own, for energy. Instead of spiking blood glucose, you can get a feel for different fats and their uses. MCTs are nice for a quick boost and adapting to ketosis [1] and the initial stage but soon enough, you want to be running on healthier fats. That said, MCTs are the 'crack of fats' increasing BHB in a linear, dose-dependent manner and increasing total brain energy metabolism by increasing ketone supply [2], having positive effects on verbal memory and processing speed in patients with impairments [3] and exerting anxiolytic and social effects [4]. Coconut oil may improve brain health by directly activating ketogenesis in astrocytes [5] and has beneficial effects on neuron survival [6] If you want an interesting combo, try a carnitine source with your longer chain fats. Long-chain fatty acids (LCFA) require L-carnitine as a transporter into the mitochondrial matrix, while the MCTs do not. While most patients do not require carnitine supplementation [7], Carnitine helps shuttle fatty acids across cell membranes to be oxidized by mitochondria, covering an important role in lipid metabolism, acting as an obligatory cofactor for β-oxidation of fatty acids by facilitating the transport of long-chain fatty acids across the mitochondrial membrane as acylcarnitine esters. Oleic acid sources do seem to curb hunger nicely. There is reduced food intake in an oleate-specific manner [8].There is a hypoglycemic effect of oleic acid and the probable dependence of glutathione [9] Watch out for saturated fats: these increase brain inflammation and activates the hypothalamic-pituitary-adrenal axis Dietary lecithin may increase the efficacy of omega-3 supplementation when their intake is combined [1] https://www.ncbi.nlm.nih.gov/pubmed/29951312 [2] https://www.ncbi.nlm.nih.gov/pubmed/29914035 [3] https://www.ncbi.nlm.nih.gov/pubmed/30367958 [4] https://www.ncbi.nlm.nih.gov/pubmed/29908242 [5] https://www.ncbi.nlm.nih.gov/pubmed/27430387 [6] https://www.ncbi.nlm.nih.gov/pubmed/28126466 [7] https://www.ncbi.nlm.nih.gov/pubmed/11879348 [8] https://www.ncbi.nlm.nih.gov/pubmed/27654062 [9] https://www.ncbi.nlm.nih.gov/pubmed/28214972
  14. Alchemica

    Ketosis as therapy

    What have I noted about running on low intakes of carbohydrates? I've been running low carbs. To the point most fruit sounded scary and I got very selective with fruits and anything carbs - occasionally a few chickpeas was my limit. I've only just started putting them back in significantly ie some brown rice - I don't have bread, cereal. pasta etc. I was very hesitant to start putting in significant carbs again as they do seem to significantly impact weight aspects for me but I was getting totally dysfunctional Why the sourpuss? Maybe it's your low carb diet In direct contrast to what advocates of low-carbohydrate diets promise—an end to mood swings and fatigue, low-carb diets can lead to pronounced feelings of depression and sadness, even rage. "People feel very angry, and their antidepressants don't work well, either" Low-carb diet may particularly have an adverse effect on those prone to low moods. “If you’ve cut our carbs and experience anxiety or depressive feelings as a result, you’re actually less likely to exercise, eat well and take care of yourself. "...the low-carbohydrate diet may have had detrimental effects on mood that, over the term of one year, negated any positive effects of weight loss" [1] Restricting carbohydrates could make it hard for you to fall and stay asleep. [2] As I mentioned in the sleep bit: Also, fasting blood glucose results have been persistently somewhat elevated causing concern. Can being low on carb intake paradoxically potentially do that kind of blood glucose dysregulation? It seems it can... “Why is my fasting blood glucose higher on low carb?” I hadn't heard of “adaptive glucose sparing” [3] My cognition was crap, probably from the months of sleep deprivation too. Persistent odd states of consciousness, too. Despite a growing body of clinical evidence suggesting that low-carbohydrate diets can be helpful for people with brain problems, including neurological, psychiatric, and cognitive disorders such as Alzheimer’s disease, a low-protein, high-carb diet may be an easier alternative to calorie restriction for people looking to preserve brain health and prevent cognitive decline [4]. These findings have been critiqued "There is a strong consensus that a diet rich in carbohydrates and fiber is crucial for brain health and Alzheimer's prevention." (along with associated fiber deficiencies also harm our guts and subsequently our microbiome, which can also pose negative long-term effects on the brain and incite brain fog, confusion, and even anxiety). ...the low-protein, high-carbohydrate diet appeared to promote hippocampal health and biology in the mice, on some measures to an even greater degree than those on the low-calorie diet [1] https://www.sciencedaily.com/releases/2009/11/091109173614.htm [2] https://www.livestrong.com/article/482729-i-cant-sleep-on-a-low-carb-diet/ [3] https://www.dietdoctor.com/low-carb/fasting-blood-glucose-higher [4] https://www.medicalnewstoday.com/articles/323772.php
  15. Alchemica

    Free Galphimia glauca

    Can spare a few people some free seed [and/or smallish quantities of research material (in exchange for an opinion in a thread)]. I'll say the first three people? Can probably do more if someone's really keen, just keeping some seed for plant meets etc. Post here then shoot me a PM. "Best time to sow is late autumn and winter in good quality seed raising mix, cover lightly as seeds need light to germinate. Place in a warm sunny position. Don't plant out until late spring/early summer, keep moist on transplant. Don't overfeed - likes impoverished soil" High-quality evidence was found to exist for the use of Galphimia glauca (galphimia) for anxiety disorders [1] Dose: Dried herb 0.6–1 g per day standardized to 0.175–0.348 mg of galphimine B Clinical trials showing equivalence to synthetic anxiolytics No adverse reactions found in studies Generalized anxiety, GAD While emerging data is encouraging, further placebo-controlled studies are needed. Galphimines have been identified as active compounds in galphimia, with the nor-secotriterpenes galphimine A and galphimine B, being shown to have the strongest anxiolytic activity. Galphimine B has been considered the primary active constituent for galphimia’s anxiolytic and sedative effect, and is the constituent standardized for clinical trials. Galphimine B has been shown to interact with serotonergic transmission in the dorsal hippocampus in rats. This occurs by increasing the frequency of neuronal discharge in CA1 cells, resulting in activation of 5HT(1A) receptors. One study in mice demonstrated that galphimines cross the blood–brain barrier, with galphimine A found to have an effect on the central nervous system. 2.5.3 Evidence of Efficacy 2.5.3.1 Preclinical A number of galphimine constituents, including galphimine B, were evaluated for their anxiolytic effects in mice using the EPM. Mice were intraperitoneally administered 15 mg/kg of a galaphimine derivative 1 hour before testing. An anxiolytic-like effect in the mice was found for both galphimine A and galphimine B, with a significant increase in the time spent in and number of entries into the open arm in the EPM. A second study on mice used a methanolic extract (standardized for galphimine B, 8.3 mg/g) at different doses (125, 250, 500, 1000 and 2000 mg/kg), which were orally administered at three different times (24, 18 and 1 hour before the test). Significant anxiolytic-like effects were found in the light–dark paradigm test and the EPM, but not the forced swimming test. 2.5.3.2 Clinical Two clinical trials have found galphimia to be an effective anxiolytic. The first was a 4-week, positive-controlled double-blind RCT, with a cohort of 152 patients with a DSM-IV diagnosis of GAD and HAMA scores ≥19 . The two groups received either galphimia aqueous extract (310 mg standardized to 0.348 mg of galphimine B), or the benzodiazepine lorazepam (1 mg). Each treatment was administered in capsule form (identical in appearance) twice daily. Both groups demonstrated a significant reduction in anxiety symptoms. There were no significant side effects reported in the galphimia group, which contrasted with the lorazepam group, in which over 21 % of people reported excessive sedation. https://neupsykey.com/herbal-anxiolytics-with-sedative-actions/ "0.175 mg of galphimine-B and administered for 15 weeks to patients with generalized anxiety disorder, showed greater anxiolytic effectiveness than that obtained with lorazepam, with high percentages of therapeutic tolerability and safety." [2, 3] Galphimia glauca has been used for many years in Mexican traditional medicine for treating mental diseases, particularly nervous hyperexcitability disorders. This plant contains galphimines which have been shown to possess the ability of modifying the frequency of discharge of dopaminergic neurons in the Ventral tegmental area [4]. Galphimine-B appears to be an allosteric modulator of 5HT1A receptors [5] It was capable of blocking positive and cognitive symptoms associated with psychosis induced by ketamine [6] Anti-inflammatory activity and chemical profile of Galphimia glauca. [1] https://www.ncbi.nlm.nih.gov/pubmed/29575228 [2] https://www.ncbi.nlm.nih.gov/pubmed/22828921 [3] https://www.ncbi.nlm.nih.gov/pubmed/17562493 [4] https://www.ncbi.nlm.nih.gov/pubmed/12567277 [5] https://www.ncbi.nlm.nih.gov/pubmed/21742023 [6] https://www.ncbi.nlm.nih.gov/pubmed/29710504
  16. This plant was once of interest at the forums and on and off of interest to me but I've not heard much of people's positive experiences with it. If you have anything to share, feel free. Radix puerariae is one of the most widely used ancient traditional Chinese medicines and is also consumed as food. Kudzu is now considered for the treatment of many kinds of addictions, metabolic conditions, pain and for it's CNS therapeutic potential. The most abundant isoflavone of kudzu root is puerarin, but it also contains daidzein, daidzin and other isoflavones It selectively suppresses ethanol intake and inhibits mitochondrial aldehyde dehydrogenase (ALDH-2, an enzyme involved in serotonin (5-HT) and dopamine (DA) metabolism and alters monoamine levels. It "specifically targets unique drug related episodic surges in dopamine, a pathophysiologic mechanism that appears to underlie much of drug-seeking behaviour." [1] " a single dose of kudzu extract (active isoflavone content of 520mg) quickly reduces alcohol consumption in a binge drinking paradigm. These data add to the mounting clinical evidence that kudzu extract may be a safe and effective adjunctive pharmacotherapy for alcohol abuse and dependence. " [study] It's intriguing as puerarin is also a promising rapid-acting antidepressant compound through AMPAR-mTOR signaling pathway activation and increased BDNF [2], exerts anxiolytic-like effects, which may be "associated with normalisation of 5-HT levels and biosynthesis of allopregnanolone in brain" [3] and alleviated the behavioural deficits induced by chronic stress [4] and may be a "potentially valuable preventative therapeutics for memory-related nervous disorders" [5]. It also possibly acts through opioid system. Available evidence from animal models shows that antioxidant and antiapoptosis activities of puerarin protect neurons against damage in dementia and Parkinson's (partially prevents the chemically-induced DA neurodegeneration in mice and rats, and stimulates striatal GDNF) and puerarin has been shown to decrease the morbidity of ischemic stroke [6]. It is neuroprotective and there are therapeutic application of puerarin-related compounds in neurodegenerative diseases It has been called a "potentially valuable preventative therapeutic for brain disorders due to their abilities to promote the neuronal cytoarchitecture and the synaptic functionality" "The antidiabetes activity of puerarin includes reduced body weight gain, improved blood glucose control, and improved glucose tolerance. R. pueraria has been used to treat diabetes for thousands of years, and Puerarin can reduce blood sugar and increase insulin receptor sensitivity in patients with type 2 diabetes". - Acute administration of puerarin significantly improves glucose tolerance in animal models and is promising in humans: - Chronic kudzu root supplementation improves glycaemic control, insulin sensitivity in animal models Kudzu root in the diet in animals is associated with a decrease in fasting glucose and improvements in both glucose tolerance (oral glucose tolerance test) as well as insulin tolerance (indicative of insulin sensitivity) - Isoflavones act as antidiabetic agents [7] and decreased food intake and body weight gain [8] and Pueraria lobata could interfere with antipsychotic-associated insulin resistance and revert overexpressed IR-related proteins [9]' -Paradoxically, there is "evidence for the role of phytoestrogenic compounds in improvement of sexual function and testosterone production in male animals" These isoflavones have been linked to "significantly improved androgenic and sexual behaviour parameters. There was also an increase in serum concentration of FSH and improvement in serum testosterone level" [10] However, like other isoflavones, puerarin, kudzu and its other phytoestrogenic components act in part as selective estrogen receptor modulators displayed preferential affinity for ERβ and altered sperm parameters [11] There are hints that they may be negative as removing dietary isoflavones in adult male rats causes obesity and diabetes in some models [12] and long-term consumption of a diet rich in soy isoflavones can have marked influences on patterns of aggressive and social behaviour [13]. This is coupled with dysregulation of the HPG-axis and thyroid function Isoflavones definitely seem like a bad idea developmentally as they "...produced a delay on the onset of puberty and "at high doses of isoflavones ... prevent the stimulation of the secretion of pituitary hormones and the production of T abolishing the onset of puberty" [14] There is possible for interactions [15] [1] https://www.ncbi.nlm.nih.gov/pubmed/26022266 [2] https://www.ncbi.nlm.nih.gov/pubmed/30284466 [3] https://www.ncbi.nlm.nih.gov/pubmed/29101599 [4] https://www.ncbi.nlm.nih.gov/pubmed/28740098 [5] https://www.ncbi.nlm.nih.gov/pubmed/28734961 [6] https://www.ncbi.nlm.nih.gov/pubmed/30693344 [7] https://www.ncbi.nlm.nih.gov/pubmed/30958562 [8] https://www.ncbi.nlm.nih.gov/pubmed/30402623 [9] https://www.ncbi.nlm.nih.gov/pubmed/30946280 [10] https://www.ncbi.nlm.nih.gov/pubmed/24489512 [11] https://www.ncbi.nlm.nih.gov/pubmed/22278629 [12] https://www.ncbi.nlm.nih.gov/pubmed/27469930 [13] https://www.ncbi.nlm.nih.gov/pubmed/15053944 [14] https://www.ncbi.nlm.nih.gov/pubmed/30924551 [15] https://www.ncbi.nlm.nih.gov/pubmed/24710899
  17. Alchemica

    Tagetes lucida

    Tagetes lucida As the last one from my garden I enjoyed over the last growing season, aiming to spread the love of this plant to 3 people this year who want to grow it with some free seed (No TAS/WA). Post a reply and I'll get back to you once seed is soon harvested. Once again, I'm just going by the way I've harvested seed from other Tagetes like patula. Hope it's the same. It has a rich spiritual background of traditional use with anti-anxiety and sedative-like properties It's been said to be "vitally important to use very fresh leaves" and experimenters state a dose of 2,000 mg - most participants felt no need to increase the dosage further to “...creates a ‘lucid’ state which can be appreciated in a number of ways: listening to music, contemplating, grooving, introspection, communication, etc. Some of the effects noted are: clarity, alertness, closed-eye visuals, body warmth, body tingles, feeling of well-being, and some time-distortion. The period of alteration lasted 2 to 3 hours in most cases and there was no interference with sleeping afterwards, although many reported increased dreaming (sometimes with weird content).” [1] It is used historically in religious ceremonies including Huichol Indians who ceremonially smoke it with Mapacho and it is also used with other sacred plant medicines [2,3] T. lucida is recommended for treating emotional and nervous disorders, often as part of a mixture with other anxiolytic plants [4] Mexican traditional medicine prescribes T. lucida for “nervios” and “susto”, two culture-bound syndromes described as illnesses characterized by a “state of bodily and mental unrest” able to decrease the ability to achieve daily goals and as a condition of being frightened and “chronic somatic suffering stemming from emotional trauma” "It is used for producing a fragrant smoke (sahumar) to ritually clean houses of evil spirits. The use in sweat baths (temazcal) and for ritual cleansing (“limpias”) are related" Anxiolytic and sedative-like activities through 5-HT1A and GABA/BZD receptors possibly through 6,7,8-trimethoxycoumarin (dimethylfraxetin). Other coumarins have also been reported from the species, such as herniarine (7-methoxycoumarin), scoparone (6,7-dimethoxycoumarin), and the dimethyl allyl ether of 7-hydroxy-coumarin, umbelliferone, esculetin and scopoletin along with flavonoids, some of them with known anxiolytic-like activity, have been reported in polar extracts of this species. Significant anxiolytic-like response effects were found in animal models from 10 mg/kg onward of the aqueous extract An influence on serotonergic neurotransmission by T. lucida was also reported in the antidepressant effects which were likely the result of modulation of serotonin reuptake/release, dependent on 5-HT1A and 5-HT2A receptors. There is not only a significant involvement of the serotonin neurotransmission in the mechanisms of central effects of this species, but also GABAergic participation [5] It is is a source of phenylpropanoid EOs: "at least four chemotypes can exist, characterized by the main presence of (a) high levels of (E)-anethole (up to 74%) and low to very low levels of methyl chavicol (11.57%) or methyleugenol (1.8%), and germacrene D; (b) high levels of methyl chavicol (up to 97%), in addition to methyleugenol, methylisoeugenol, and germacrene D; (c) high levels of methyl eugenol (up to 80%), in addition to methylchavicol and methylisoeugenol; and (d) high amounts of nerolidol (around 40%), in addition to methyleugenol, methylchavicol, and caryophyllene oxide" [1] https://www.world-of-lucid-dreaming.com/mexican-tarragon-tagetes-lucida.html [2] https://www.americanherbalistsguild.com/…/jahg_spring_2017_… [3] http://entheology.com/plants/tagetes-lucida-marigolds/ [4] https://www.mdpi.com/1420-3049/23/11/2847/pdf [5] https://www.ncbi.nlm.nih.gov/pubmed/26873624
  18. Alchemica

    Free Galphimia glauca

    Did you have luck germinating this @Glaukus? As one of my first attempts with seeds, I may have been too hasty collecting seed. Revisiting this, from the latest study, it seems to be a rather cumulative effect, not so much acute effects. A gradual improvement was observed in GAD - 68.1% of the patients were completely asymptomatic at the end of the administration of the experimental treatment, and 92.0% of patients were considered with therapeutic success. It managed to progressively improve the activities of patients in daily life, as well as provide palpable improvements regarding their tranquility and their perception of anxiety and depression. https://www.ncbi.nlm.nih.gov/pubmed/30834253
  19. Alchemica

    Tagetes lucida

    First lots have been sent out and received with a couple of people trying the herb too. If they have any experiences with the plant feel free to let us know. Sorry to be a pain @Humbolt but I'm not comfortable sending to Tas/WA these days (thought I put that in but must have not) So @Paradoxical I'll send some seeds for you More on the plant: In traditional medicine, it has been said the herb "alleviates crazy people and those astonished and frightened by thunder". While a simple tea was claimed not to work, 2g dried and powdered, administered with juice was found effective, or a fresh alcohol tincture (Lazar, 2002 via The Garden of Eden) In other sources " The infusion of one bundle with water makes two to three cups of an aromatic tea, a sufficient dosage to produce profound stimulating and aphrodisiac effects" [1] It has featured in snuff blends "...the Tagetes herb clears thinking, relieves tension, aids emotional control" and a fermented tea, which is prepared the same way Sinicuichi (Heimia salicifolia) is prepared [2]. May have more seeds too soon
  20. Who else sprouts/microgreens? I decided I needed a new healing hobby. Gardening is good but the effort involved when I'm not well and heat in summer is too much. I still appreciate being in close proximity to plant life. You get to watch the seeds spring to life magically and then without mass effort in the garden, get dense nutrition (and phytochemicals). I took up sprouting/microgreens after having a short trial on broccoli sprout powder and thinking it could be good longer term. They're also good as they are easy behavioural activation when I'm feeling unwell and force me to keep tidy - it's something that embodies care, embraces life, encourages things like growth, self-care and cleanliness, shorter-term and longer-term goals and nurtures your health in return. Also, after switching to a super planty diet, I noticed lentils etc don't agree with me but lentil sprouts are fine. In general, germinated seeds, particularly microgreens, have more bioactive compounds than raw seeds [1] "Seed sprouting is a widely used natural processing method, which not only improves nutritional properties, decreases levels of antinutritional constituents but also enhances concentrations of bioactive compounds and antioxidant activity resulting in improved nutraceutical properties of seeds and creates a functional component for healthy food production" The concentration of proteins, fibre and bioactive compounds as well as bioactivity increased in the sequence: raw seeds-sprouted seeds-microgreens, while the content of total carbohydrates decreased. "Iron and zinc are still the most widespread deficient micronutrients in global food systems, known as ‘hidden hunger’ and are currently of the greatest concern when considering the nutritional value of vegetarian diets: sprouted seeds and microgreens are a good source of Fe and Zn with possibly increased bioaccessibility." "Like isoflavone concentrations, the contents of other phenolic compounds and non-phenolic metabolites as triterpene saponins increased in the following order: raw seeds < sprouted seeds < microgreens." [1] https://www.ncbi.nlm.nih.gov/pubmed/30602699 Now sprouted pretty much anything I could possibly find to sprout in the house. Soybeans, chickpeas, lentils, broccoli, mustard, radish, red clover, fenugreek etc. The works. Gut's finally coming back to some normality, contrary to simply cooked forms etc. Also set up a microgreens grow room, including wheatgrass. Sprouts are life potential, ignited. We awaken the nutrition inside the seed... "You’re growing a garden right in your kitchen, using your own energy to make the magic happen. It’s hyper-local food at its best! No chemicals or pesticides during the growing process, or fossil fuels for transportation. Could sprouts be the perfect food?! The quality of protein and carbohydrates improves, as the sprouting process begins to break down the complex proteins and starches into amino acids, peptides, and simple carbohydrates needed by the seed to grow. At the same time, anti-nutrients such as phytic acid, protease and amylase inhibitors are neutralized. This makes a sprout very easy to digest with highly absorbable nutrients [not to mention the enhancement of bioactive phytochemicals] Make sure that your jar or sprouting container is thoroughly clean, that you’re rinsing your sprouts with cool water twice daily, and that your sprouts have plenty of airflow." [1] I agree - Risks and Benefits "They are pretty energizing, and I enjoy the taste of them" "...a good choice for someone with a sensitive gut" "For people with problems digesting certain foods, sprouted germs might seem better for them, and they are less allergenic to people with sensitivities." "While sprouted grains and other nutrient-blocking seeds won’t be completely free from all antinutrients after soaking and sprouting, it’s a much better option". Broccoli: How to At least nine clinical studies of neurodevelopmental conditions like autism spectrum disorder and schizophrenia are promising. Preliminary evidence that sulforaphane may improve symptoms of autism spectrum disorders with improvement in social interaction, in abnormal behaviour, and verbal communication. It is promising in neurodegenerative conditions in animal models. It is "possible that dietary intake of cruciferous vegetables including glucoraphanin (or sulforaphane) may prevent depression induced by stress and/or inflammation". It has potential to improve cognitive function in patients with schizophrenia [1] Sulforaphane may be a useful intervention for neurodevelopmental and neurodegenerative diseases because it "corrects underlying aspects of the diseases process, rather than merely alleviating symptoms". After Nrf2 pathway activation, over two hundred genes are induced and exert detoxification and antioxidant defense. - a naturally occurring Nrf2 activator - potent anti-oxidant and anti-inflammatory activity. - epigenetically enhances neuronal BDNF expression and its TrkB signaling pathways [2] - increased blood GSH levels in healthy human subjects following 7 days of daily oral administration [3] - prevented depression-like phenotype in mice after inflammation, or chronic social defeat stress [4] - following oral administration, it had an effect on histone deacetylase activity following a single dose in animal models. - improve glucose tolerance through the up-regulation of insulin signaling [5] Tip: add some radish/mustard seeds to your sprouting mixture: "...the addition of radish, rocket and rape sprouts to broccoli sprouts could promote the hydrolysis of the glucoraphanin to sulforaphane to 2.03, 2.32 and 1.95-fold, respectively, compared to single broccoli sprouts while the formation of non-bioactive sulforaphane nitrile in these three groups decreased greatly" [6] There is evidence in favor of the safety of strategies that target the activation of Nrf2: Serum levels of thyroid-stimulating hormone, free thyroxine and thyroglobulin were not affected by the treatment, and neither was the thyroid autoimmunity status [7] [1] https://www.ncbi.nlm.nih.gov/pubmed/30199394 [2] https://www.ncbi.nlm.nih.gov/pubmed/27735126 [3] https://www.ncbi.nlm.nih.gov/pubmed/29888232 [4] https://www.ncbi.nlm.nih.gov/pubmed/30386243 [5] https://www.ncbi.nlm.nih.gov/pubmed/30091431 [6] https://www.ncbi.nlm.nih.gov/pubmed/30263824 [7] https://www.ncbi.nlm.nih.gov/pubmed/30735751 Fenugreek "Sprouting has shown to improve the nutritional profile of fenugreek seeds and decrease the fiber content such that it gets digested and absorbed in the system more easily. Also, germinated fenugreek seeds have higher antioxidant content and enhanced antidiabetic effect" [review] Fenugreek is known for its medicinal properties such as hypocholesterolemic, antidiabetic, anticancer and gastroprotective properties but it's healing properties extend beyond that. Fenugreek fibre in a breakfast meal increased feelings of fullness and reduced hunger, as well as reduced energy intake. It had comparable effects to metformin. When fenugreek was incorporated into food, it reduced the glycemic index (GI) by 21%. 10 g/day significantly decreased fasting blood glucose and HbA1c, serum levels of insulin, homeostatic model assessment for insulin resistance, and total cholesterol and triglycerides, and it increased serum levels of adiponectin in type 2 diabetic patients Clinically fenugreek seed leads to improvement in insulin sensitivity [1]. An animal study shows significant anti-anxiety effects [2] and it improves learning and memory process and has significant potential as an antiamnesic agent [3]. It has neuroprotective [4] and antidepressant activity in part by modulation of MAO-A/B [5] It demonstrated significant anabolic and androgenic activity in human studies [6]. Improves sexual function and increases serum testosterone in healthy middle-aged and older men [7] and sexual desire and arousal in women [8] It contains flavonoids, terpenoids, phenols, proteins/amino acids, saponins, and tannins. Galactomannan from fenugreek seeds is a prebiotic [9] Fenugreek may help protect against liver changes induced by chronic alcohol consumption. Health Benefits of Culinary Herbs and Spices: https://doi.org/10.5740/jaoacint.18-0418 [1] https://www.ncbi.nlm.nih.gov/pubmed/29518003 [2] https://www.ncbi.nlm.nih.gov/pubmed/27639708 [3] https://www.ncbi.nlm.nih.gov/pubmed/29681009 [4] https://www.ncbi.nlm.nih.gov/pubmed/27893738 [5] https://www.ncbi.nlm.nih.gov/pubmed/25176235 [6] https://www.ncbi.nlm.nih.gov/pubmed/30356905 [7] https://www.ncbi.nlm.nih.gov/pubmed/26791805 [8] https://www.ncbi.nlm.nih.gov/pubmed/25914334 [9] https://www.ncbi.nlm.nih.gov/pubmed/29876118 Wheatgrass Along with chlorophyll, it is a source of a large variety of vitamins, minerals, enzymes and amino acids (while being considered gluten free). In the passage from grains to sprouts to wheatgrass, the quantity of flavonoids increases being rich in flavonoids, particularly apigenin. A source of triterpenoids, anthraquinol, alkaloids, tannins, saponins, sterols, squalene, caryophyllene and amyrins Clinical studies show benefit as an adjunct to cancer therapy and benefit in rheumatoid arthritis, ulcerative colitis, hematological diseases, diabetes, obesity, and oxidative stress. Currently available evidence confirms the safety of wheatgrass and its products [1] [1] https://www.ncbi.nlm.nih.gov/pubmed/26156538
  21. Sprouts featuring in recent news Johns Hopkins Medicine researchers say they have further characterized a set of chemical imbalances in the brains of people with schizophrenia-related to the chemical glutamate. And they figured out how to tweak the level using a compound derived from broccoli sprouts. They say the results advance the hope that supplementing with broccoli sprout extract, which contains high levels of the chemical sulforaphane, may someday provide a way to lower the doses of traditional antipsychotic medicines needed to manage schizophrenia symptoms It’s possible that future studies could show sulforaphane to be a safe supplement to give people at risk of developing schizophrenia as a way to prevent, delay or blunt the onset of symptoms Further research is needed to learn whether sulforaphane can safely reduce symptoms of psychosis or hallucinations in people with schizophrenia. They would need to determine an optimal dose and see how long people must take it to observe an effect. ” https://neurosciencenews.com/broccoli-sprout-schizophrenia-13051/
  22. Some experiments trying to get better sleep, rough notes I kept while I was quite struggling so excuse the poor referencing, I'm still struggling getting sleep at times. I get some effects from Jujube/Zizyphus seed. It's worth a shot for people. Finally got around to trying some Jujube seed extract. Didn't get much from the fruits. I like it, initially I blended it with a bit of Ashwagandha. I don't get worthwhile kava effects anymore but this is quite nice at a decent dose. I'll likely use it for sleep (wasn't expecting it to be strong enough to consider using for sleep) It has been also traditionally used for psychiatric disorders in Chinese and Korean medicine. Traditionally, one of the main functions of jujube, as described in herbal medicine, is to benefit our brain by calming down the mind and improving quality of sleep. Jujube possesses neuroprotective activities, including protecting neuronal cells against neurotoxin stress, stimulating neuronal differentiation, increasing expression of neurotrophic factors, and promoting memory and learning. The plants secondary metabolites modulate GABAergic activity and the serotonergic system, interestingly the postsynaptic 5-HT1A receptors. Intriguingly, it exhibited significant effects on both the expression and activation of GABAA receptors. It improves memory impairment through BDNF/TrkB signaling and is suggested to have a protective effect against chronic depressive disorders The Zizyphus seed/hops/chamomile is nice, more chill than sleep for me but last night I added valerian and lemon balm. Once again, for someone who has severe GABAergic dysregulation/tolerance and sleep issues, it's quite anxiolytic but not so pronounced in it's sedative action for me. I'll get there eventually. "This clinical investigation on safety and effectiveness of a herbal compound made of valerian, hop, and jujube opens interesting perspectives on usage of herbal compound to manage primary insomnia." https://www.ncbi.nlm.nih.gov/pubmed/28603433 Explored some valerian by itself as a sleep aid for a bit. Once again, anxiolytic, not exactly sleep promoting for me. Added things like lemon balm etc. They're something you can tune to. Interestingly, the use of combined valerian and lemon balm phytomedicine extract provides a viable treatment option for hyperactivity, attention deficits, and impulsiveness, in addition to nutritional and lifestyle modifications Valeriana officinalis extract is a popular herbal medicine used for the treatment of anxiety and sleep disorders. The anxiolytic and sedative effects are mainly attributed to the modulation of GABAergic transmission but the selective interactions of valerian extract and valerenic acid with Group I and Group II mGluR may represent an alternative explanation for the anxiolytic properties of this plant. Binding affinities could also be demonstrated at some of the screened melatonin (ML1 and ML2) and serotonin (5-HT4e, 5-HT6 and 5-HT7) receptor subtypes. A single oral dose of valerian modulates intracortical facilitatory circuits. While none of the valerian extracts displayed sedative effects, they did produce pronounced anxiolytic and antidepressant effects in one study. Valerian root extract may reduce emotional, physical, and behavioral symptoms of premenstrual syndrome. Its pharmacological activity may result from interactions among multiple constituents rather than any one compound or class of compounds. The primary active constituents include valerian’s essential oil and its corresponding sesquiterpenes (valerenic acid), the iridoid esters (valepotriates) Throughout history, lemon balm has been used medicinally to heal wounds, prevent and treat cold sores, soothe nerves, improve sleep, and strengthen the memory and the mind. The ancients are known to steep lemon balm in wine, a traditional medicinal dosage form, for fevers and to uplift the spirits. Lemon balm contains more than 100 chemicals including the flavonoids (quercitrin and rhamnocitrin), which have an antioxidant effect; phenolic acids and tannins, primarily rosmarinic acid; the 7-glucosides (apigenin, kaempferol, quercetin, and luteolin); caffeic and chlorogenic acids; triterpenes; and volatile oils citral a, citral b, (10%-30%), and citronellal (30%-40%) that render its lemony flavor and aroma. Some evidence indicates that valerian preparations may have a mechanism of action and clinical characteristics that differ from the benzodiazepine-related sedative/hypnotics, making them more suitable for long-term use. A one-time valerian 1600mg dose, often used to treat insomnia, does not appear to impair driving simulator performance after acute ingestion. How a few things impact at the EEG level: "Under diazepam the power in the theta frequency band decreased while it increased in the beta band. In contrast, some plant extracts showed an increase of power in the theta frequency band, but no increase in the beta frequency range. Valerian extract, which was administered in both studies, displayed an increase of power in the delta and theta band and a decrease in the beta band. Kava-kava preparation caused a decrease of relative alpha power in the vigilance controlled EEG. This effect was more pronounced 6 h than 2 h after drug administration. In a polygraphic sleep study two dosages of a Kava-kava preparation, given for one night, did not alter the sleep stage distribution significantly, while the sleep spindle density was increased.The most consistent single effect was a power increase in the theta band. Fronto-centrally a decrease in power in the high frequency beta band was also observed 180 minutes post administration Valerian Absolute power in the theta frequency band increased 120 minutes post administration Power increases were also observed in the neighbouring delta and alpha bands Total power remained unchanged under Lavandula extract 120 minutes post administration, and there were only very few changes in the different frequency bands. 180 minutes post administration total power decreased in the fronto-centrallead under RT and RS conditions. This power decrease could also be seen for absolute power in all frequency bands Total power increased 120 minutes post intake of Passiflora extract in the occipito-temporal lead. Other changes were essentially restricted to an increase in theta power 120 minutes post Lemon Balm administration total power increased fronto-centrally under resting conditions (RS). At this time point power increases were observed with a maximum in the delta, theta and slow alpha band occipitotemporally. For the fronto-central lead these power increases extended from the theta to the beta frequency band. Californian poppy: 120 minutes post administration absolute and relative power increased mainly in the theta and alpha frequency bands'"
  23. I've been revisiting this trying to improve sleep by changing macronutrient profiles a bit. I was finding restricting carbs with higher protein intake was seemingly messing with sleep even more. Dietary intake habits (affecting the state of nutrition) are perceived to be one of the factors predisposing, causing and consolidating sleeping disorders When it came to one study [1], two thirds of the subjects with sleep difficulties were characterised by an inappropriate state of nutrition. Sleep disorders could have been influenced by the low energy value of the subjects’ diets, as it has been shown that lowering the energy intake significantly decreases melatonin, a low intake of assimilative carbohydrates could have an influence on pinealocytes and the sleep-wake cycle. Similar results were seen in [2] where beans/carbohydrates and dairy were associated with improved sleep quality. "It was ascertained that, despite the insufficient energy value of the subjects’ diets, too much energy came from proteins [they] showed insufficient energy value, insufficient intake of assimilative carbohydrates, fibre, K, Ca, vitamin D3 and water with simultaneous excessive intake of Na, P, Fe, Zn, Cu and vitamins: A, B2 , B6, B12, PP, and C" Inbalanced intake of energy and nutritive value could have affected the proper synthesis of neurotransmitters regulating sleep-wake cycle and melatonin hormone. https://www.ncbi.nlm.nih.gov/pubmed/29265779 https://www.cureus.com/articles/16904-influence-of-dietary-intake-on-sleeping-patterns-of-medical-students
  24. Sounds good, hope the terpenes help - keep us updated! Sorry to hear you're being troubled with more struggles, that's no fair
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