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Anodyne

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About Anodyne

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    Ragged Company

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    Sydney, Oz

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  1. Anodyne

    Meet up: Sydney, Central Coast, Newcastle

    Yar that's what I thought too - maybe people are missing the fb link above & scrolling back up too far, & finding the details from the Feb 2018 (private) meet instead of this upcoming one?
  2. Anodyne

    Post your track of the day

    Almost done with you, 2018. Thankyou for the last-minute lightning storm, that was pretty damned cool, I did appreciate that, but too little too late. And as for most of the rest of this year, you can fuck right off. At this point if I reckon if I can make it thru the next 91 minutes without winding up in the ER, I'll count that as a win. Good riddance & in with the new! The Mountain Goats - 'This Year'
  3. Anodyne

    Watch this space

    Don't get me wrong RC, I'm buying what you're selling re: shady motives behind our drug policies. But I just can't make out how this particular piece goes with that particular conspiracy theory. If you wanted to pick an opioid for crowd-control purposes... sufentanil isn't it. And this specific formulation that's been approved here - "Dsuvia" - is even less so. It's going to be expensive, highly restricted, and may well be the shortest-acting opioid in therapeutic use today. If people in the US want to take something that fits that description, then they can just go buy some of the huge volume of illicit fentanyl that's been raining down on that continent recently... that lasts twice as long, plus you don't need to steal it from army medics or hospitals. And if people decide that sufentanil is the bees knees after all, and there actually *is* a demand for it... then it will just be made by the kilo in a lab in China. Either way, the FDA decision to approve this drug (a limited-application version of this opioid which has been in use as an anaesthesic since the 80's) isn't really going to make much difference either way that I can see. As far as fentanyl analogues which are currently available in the US, Dsuvia is barely a drop in that ocean. And if people do really want to take this specific one recreationally, I doubt they're going to care whether it's been FDA-approved or not. And all of this seems to apply even less to Australia in light of this year's codeine restrictions - gotta say, if they're trying to subdue us with opioids, that seems like a really arse-backwards way to go about it. But I'm all onboard with an Operation Opium Flood government program - perhaps they just need a little help getting started - maybe I should offer to coach them?
  4. Anodyne

    best ice breaker

    I'd have to go with this one that I once overheard an escort say: "I find that sex is the best icebreaker"
  5. Anodyne

    Quotes of the day.

    Some memories lay heavy on my mind Some days I've cared & some days I'd rather die Sometimes I get so thirsty That I drink til I'm blind I gave up on tomorrow, tonight. In my dreams there's a needle & a spoon A pair of dice, a loaded gun, oh baby, me & you And you're sawing on a fiddle And I'm wondering which to shoot Everything's so complicated now I am coming down - Lost Dog Street Band "Coming Down"
  6. Anodyne

    don't cha love it when...

    DCLIW amateur translations end up being inadvertently poetic. The manual for my benchtop power supply warns that running the unit above the recommended voltage "may cause human early failure"
  7. Anodyne

    Enteric coated capsules, sz 4, 5

    If you have no luck with sources, you could always try this method of DIY coating regular gelcaps? Homemade enteric coated capsules - how it's done I've not tried it myself, but if I were going to, I reckon I'd skip 69rons original method (which sounds slow, fiddly & unreliable) & try the variation that Orbiting describes on page 2.
  8. Anodyne

    Does someone legally have to have an identity?

    Yeah you legally have to register births (so they know if you're sending the kids to school or not), and I think that goes for deaths as well (because if people were just allowed to bury grandma in the backyard without telling anyone, that could lead to some problems...), but I don't think the gubmint care too much about about what happens in between. So long as you don't have any undeclared taxable income, at least. Not really sure how you'd go about erasing your identity though - presumably you're already in the system, not having ID documents doesn't really change that... And it does mean that you can't legally do certain things like drive a car, get on a plane, or leave the country - and may run into hassles if you need medical care, get stopped by cops, etc. Side note: if anyone does need to get back into the system after a period of living offgrid without ID, gov't departments (Centrelink, Medicare, Dept. of Housing, etc) have supposedly gotten a lot better about this than they used to be. I know a few folks who needed to get ID papers after being "without fixed abode" for awhiles, and it wasn't the complete Kafkaesque nightmare I was expecting it to be. The social worker types were pretty good about it & helped out with stuff like applying for jobs or rental properties which would normally ask for your previous address, work history, etc.
  9. Anodyne

    Post your track of the day

    I think I'm in love... (may be NSFW) Springwater - Birdcloud Saving Myself For Jesus - Birdcloud
  10. Anodyne

    Quotes of the day.

    This might be the most perfect review of a band that I've ever read: "FIDLAR makes me want to wait and kill myself later." - comment from FIDLAR’s Are You High? (ft. the 90s) video
  11. Anodyne

    What's the consensus on these?

    Well I know the question was "what's the consensus?" and that has been "not cubensis", but I'm gonna go against the grain /with karode here & say that they are. I spy with my little eye: *Gills that are pale because they've dropped all their spores *Faint remnants of veil (on the stem) with dark purple spores *Blue staining (streaks on stems) I've seen all these features before, they're well within normal range for cubes (so not even talking weird local mutations or anything) - especially for mature specimens that have caught some heavy rain. But if you're still not convinced, I'm sure I can find a home for them!
  12. Anodyne

    Topical tropanes and... sweating?

    Additional safety note when handling tropane solutions: DON'T RUB YOUR EYES! This lasted 24hrs+... (sorry I know the photos are slightly out of focus, but so was my vision! )
  13. Anodyne

    Topical tropanes and... sweating?

    Some disjointed thoughts... Just curious - have you used the glycopyrrolate wipes? Afaict it’s used for this purpose over other antimuscarinics (AM’s) not only because of the blood-brain barrier thing, but also because it’s selective for M3 receptors - the kind involved in peripheral gland stuff. Whereas most (all?) of the naturally-occurring compounds have some central activity & are considered “non-selective” (this isn’t 100% accurate, but they’re at least *less* selective). And leaving aside the central effects, you can also expect peripheral side-effects like dry mouth & eyes. Glycopyyrolate is also significantly less lipophilic than the 2 most common naturally-occurring AM's (atropine & scopolamine) - and so is better suited to topical application, as it's more inclined to stay put & not go sneaking off over membranes to cause mischief elsewhere in the body. Don't be put off by the title, the intro of this paper: Pharmacokinetics and Pharmacodynamics of Glycopyrrolate in the Horse (2012) gives a good rundown of the general history/chemistry of various AM's and how this has informed their applications. Take the literature about reduced side-effects with different tropane ROAs with a grain of salt: eg. you will read claims that transdermal scopolamine has less central/adverse effects than oral, but a large part of that difference lies in the slow release & therefore lower peak drug levels (ref) - it’s not necessarily to do with the route per se. Also, if you’re aiming for something like the glycopyrrolate wipes, then you actually want local activity without absorption (i.e just the “dermal”, minus the “trans-“), and not many papers make this distinction between topical/transdermal. If you do make up a topical cream, some stuff to keep in mind: - make a large batch (so you can standardise a dose properly - atropine & hyoscine are quite heat-stable & should keep a long time if the base itself is stable) - make sure it’s homogenous (tropanes are potent, you don’t want any pockets of cream that are 10x as strong) - use an aqueous base (you’re aiming for local activity, not transdermal absorption - so no DMSO, no oily salves) - alternatively, make up an aqueous solution to apply via wipes/spray: a patent for glycopyrrolate wipes settled on 10mg (oral dose is 1-4mg/day) dissolved in 1ml of 33% EtOH in water (eg. vodka) for each wipe - so maybe you could use those ratios as a rough starting place? The patent discusses some of the issues with consistent dose/applications via this method & how they addressed them - don’t drive (possibility of various CNS effects, also a common side-effect which impairs your eyes' ability to focus) - be aware of the half-life & other metabolic issues relating to the active ingredient(s) - half-life can be *long* for some of them (I mean both: some actives & some effects) so that you might get some cumulative effects even with once-daily dosing; and pharmacokinetic variations can be major (not just between individuals, but also individual responses at different times) and involve a lot of factors - not least the many, many drugs that might have significant interactions. - many people get mild skin reactions from topical AM’s (esp. with repeat applications) which can also affect absorption (irritated skin has higher bloodflow, lower barrier effect) So that's how I'd be starting as far as prep was concerned. But now let's backtrack & consider whether this is actually a good idea. This class of drug is used to treat excessive sweating, that is true. But that use is generally limited to pretty severe cases - e.g. where disease/surgery has impaired their autonomic nervous function (to the point where their hyperhidrosis is causing dehydration or problems regulating body-temp). Another main use is in palliative care for terminally ill folks who aren’t concerned about long-term side-effects and just want to be free of their “death-rattle” & have some dry sheets before they die. And even in these cases, many patients choose to stop taking their meds due to the side-effects. A potential risk of any kind of regular long-term use is the possibility of “cholinergic rebound” when you stop. There have been cases where people taking scopolamine for motion-sickness got withdrawal syndromes after only a few days to a week of daily use (includes transdermal use). That side-effect seemed to be only temporary & could be managed by tapering down off the drug, but definitely proceed with caution here. Sweating is pretty important in regulating body temperature, and if your body thinks that system isn’t working properly it might try to compensate. Compensatory hyperhidrosis seems to be a major issue after sympathectomy surgeries (sometimes used as a last-ditch treatment for severe hyperhidrosis) - and while that specific mechanism mightn’t apply here to AM drugs, there might be some equivalent one. Even in the short-term, your actual intended effect (of reducing sweating) alone can be dangerous - people on AM’s have increased risk of hyperthermia, and need to monitor their body temp manually to make sure they aren't overheating. Especially if hot weather &/or physical exertion are going to be involved, please use extreme caution when experimenting with this. For eg: try treating only some areas of skin, carry a thermometer to monitor your body temp, be sure to continue using other basic cooling methods as well, and make sure you have plenty of water & some method of rapid-cooling (ice-packs, cool creek to jump into, etc) in case of emergency - heatstroke is a miserable experience. Also be triply-cautious when combining with any psychoactives known to affect temp-regulation... MDMA in particular is a big one there. The researchers who were looking at treating hyperhidrosis in physically-active patients were concerned even about the effects of caffeine! - and while that might be overkill (for regular ambient temps & activity levels anyway), it does at least give you an idea of the level of awareness & attention to detail you want to have going into an experiment like this. I'd be less worried about a tropane OD, and more concerned that you're taking away a fairly major safety net that we don't often have to think about. Even if you're only removing part of that net, it's still an important function that you probably should try to replace with conscious monitoring (like those poor people that can't feel any pain who need to keep visually checking all their body parts to be sure that their hand isn't resting on a hotplate or something). Not wanting to over-dramatise or exaggerate the risks here - this isn't necessarily a risky thing on its own...it just has lots of ways it could become risky. But if you're mindful of the potential, and proceed patiently & with caution I think most of those could be minimised? Other options that spring to mind: deodorants based on bentonite clay; washing with witch hazel (or other herbal astringents), &/or vinegar; physical cooling (apparently just drinking a slushie can lower your core temp by ~0.5 C & reduce sweating, for a while at least). Another thing you could try maybe is hyoscine butylbromide (available OTC), which is sometimes used for hyperhidrosis as it’s a form that’s blocked by the BBB. Or if you want a DIY experimental treatment, how about tap-water iontophoresis - looked more promising & less risky? Here are some refs, the last one has instructions for a DIY apparatus: http://Treatment of Palmar Hyperhidrosis with Tap Water Iontophoresis (Kim et al, 2017) Long-term efficacy and side effects of tap water iontophoresis of palmoplantar hyperhidrosis--the usefulness of home therapy (Hölzle & Alberti, 1987) A Simple User-made Iontophoresis Device for Palmoplantar Hyperhidrosis (Nagar & Sengar, 2016) And if you find that the iontophoresis isn't effective enough on its own (i.e. just w/plain tap water), it has also been used to facilitate dermal delivery of drugs (eg. glycopyrrolate solution) - so you could always add some brug drops to the water later on for a double-whammy? And just as a general safety note for handling plant tropanes, (especially any kind of extract/concentrated form) - remember that they are absorbed through the skin & use appropriate caution: don't handle with bare hands, clean up any spills & wash/mop the area afterward, make sure everything is clearly labelled, and so on. For solutions I'd consider adding some kind of coloured dye to make spills more visible (only because invisible spills would worry me more than stained skin). If experimenting with solution/wipes, I'd also wonder about the possibility of any excess/unabsorbed actives getting absorbed by my clothes - not sure if/how they address that with the glyco-wipes? maybe it's not a problem - but I wouldn't be asking anyone else to wash my clothes until I knew the answer.
  14. Damn, I'd been struggling with this exact issue - knowing that I should be socialising, but finding the negatives (mostly from my own anxiety) keep outweighing the positive & so I can't escape the idea that I'm just making things worse for myself long-term, by creating/reinforcing all these negative associations... not sure how to break the cycle. I'm even aware of the huge body of research into how social isolation impacts mental health, but a little voice inside keeps pointing out the flaws & blind spots of those studies, & insisting that they don't apply to *me*... Real health bullshit not helping - when I don't have the energy to even do basic chores, it's too easy to say "oh but of course I should postpone social activities until I'm feeling better" - but when that happens for 3 months straight it kinda starts to feel like an excuse no matter how serious the illness is. I came here because I remembered you writing about overcoming anxieties to do social stuff & wanted to ask for some tips... sorry to hear you've been struggling too mate - happy the meds are a help for you.
  15. It's legal here in Australia too. At least, that's what the RSPCA website tells me (no irony) Some states will even pay you to kill the dogs. You need to hand in the scalps as proof though, so you'll have to choose between the bounty or sewing yourself a dog-scalp patchwork coat for dog-intimidation purposes. Can't have everything I suppose.
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